Antigrippin - instructions for use, dose, side effects, contraindications

sodium hydrogen carbonate 644.00 mg, citric acid 1328.00 mg, sorbitol 317.00 mg, povidone 16.00 mg, sucrose 1793.00 mg, sodium cyclamate 42.00 mg, aspartame 20.00 mg, acesulfame potassium 15.00 mg, flavoring lemon 55, 00 mg, caramel coloring 15.00 mg, honey flavoring 45.00 mg.

Chamomile:

sodium hydrogen carbonate 644.00 mg, lemon acid 928.00 mg, sorbitol 317.00 mg, povidone 16.00 mg, sucrose 2058.00 mg, sodium cyclamate 42.00 mg, aspartame 20.00 mg, acesulfame potassium 15.00 mg, extract of chamomile 250.00 mg.

Description:

Honey-lemon powder: powder of varying degrees of granulation, consisting of particles from white to grayish-beige, with a specific odor.Inclusions are dark brown.

Chamomile powder: powder of varying degrees of granulation, consisting of particles from white to beige and light brown in color, with a specific odor. Inclusions are brown.

Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic means + H1-histamine receptor blocker + vitamin)

ATX: & nbsp

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Combined drug.

Paracetamol has analgesic and antipyretic effect; eliminates headache and other types of pain, reduces fever.

Ascorbic acid (vitamin C) participates in the regulation of oxidation-reduction processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine - blocker H1-histamine receptors, has an anti-allergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, lacrimation, itching and redness of the eyes.

Indications:

Infectious and inflammatory diseases (acute respiratory viral infection, influenza), accompanied by fever, chills,headache, joint and muscle pain, nasal congestion and pain in the throat and sinuses of the nose.

Contraindications:

- Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.

- Erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation).

- Pronounced renal and / or hepatic insufficiency.

- Alcoholism.

- Closed-angle glaucoma.

- Phenylketonuria.

- Hyperplasia of the prostate.

- Children's age (up to 15 years).

- Pregnancy and lactation.

Carefully:

Pacute and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), viral hepatitis, alcoholic hepatitis, elderly age.

Dosing and Administration:

Inside. Adults and children over 15 years of age per 1 packet 2-3 times a day.

The contents of the sachet should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the resulting solution immediately drunk. It is better to take the drug between receptionsand food. Maximum daily beforebehind -3 sachet. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses should be at least 8 hours.

Duration of admission without consulting a doctor is no more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.

Side effects:

The drug is well tolerated at recommended doses.

In single cases there are:

from the side of the central nervous system: headache, fatigue;

from the digestive tract: nausea, pain in the epigastric region;

from the endocrine system: hypoglycemia (up to the development of coma);

from the hematopoiesis: anemia, hemolytic anemia (especially for patients with deficiency of glucose-6-phosphate dehydrogenase); extremely rare - thrombocytopenia;

allergic reactions: skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions (including anaphylactic shock), multiform exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome);

other: hypervitaminosis C, metabolic disorders, sensation of heat, dry mouth, paresis of accommodation, urinary retention, drowsiness.

All side effects of the drug should be reported to the doctor.

Overdose:

Symptoms of an overdose of the drug are due to the substances in its composition. The clinical picture of acute intoxication with paracetamol develops within 6-14 hours after its administration. Symptoms of chronic intoxication appear after 2-4 days after an overdose.

Symptoms of acute intoxication with paracetamol: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Symptoms of chlorphenamine intoxication: dizziness, agitation, sleep disorders, depression, convulsions.

Treatment: symptomatic.

Interaction:

Ascorbic acid

- increases the concentration in the blood of benzylpenicillin and tetracyclines;

- improves absorption in the intestine of iron preparations (converts trivalent iron into bivalent); can increase excretion of iron with simultaneous application with deferoxamine;

- increases the risk of developing crystalluria in the treatment of salicylates and sulfonamides short-acting, slows the excretion of acid by the kidneys, increases the excretion of drugs that have an alkaline reaction (incl.alkaloids), reduces the concentration of oral contraceptives in the blood.

- increases the total clearance of ethanol;

- with simultaneous use reduces the chronotropic effect of isoprenaline.

Can both increase and decrease the effect of anticoagulant drugs. Reduces the therapeutic effect of antipsychotics (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Simultaneous reception of barbiturates increases the excretion of ascorbic acid in the urine.

Chlorphenamine maleate

Chlorphenamine maleate enhances the effect of hypnotic drugs.

Antidepressants, antiparkinsonian agents, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation).

Glucocorticosteroids - increase the risk of developing glaucoma.

Ethanol enhances the sedative effect of chlorphenamine maleate.

Paracetamol

In the interaction of paracetamol and inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increases production of hydroxylated active metabolites, which allows the development of severe intoxication with small overdoses.

Against the background of paracetamol ethanol promotes the development of acute pancreatitis.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxic effects.

Simultaneous reception of diflunisal and paracetamol increases the concentration in the blood plasma of the latter by 50%, increasing hepatotoxicity. Simultaneous reception of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricosuric drugs.

Special instructions:

When taking metoclopramide, domperidone, or colestyramine, it is also necessary to consult a doctor.

With prolonged use in doses much higher than recommended, the probability of impaired liver and kidney function is increased, control of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid may distort the indicators of laboratory studies (quantitative determination of glucose and uric acid in the blood plasma, bilirubin, activity of "liver" transaminases, LDH).

To avoid toxic damage, the liver paracetamol should not be combined with the reception of alcoholic beverages, but also to people prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis. Assigning ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. In patients with elevated iron levels in the body, ascorbic acid should be used in minimal doses.

In one bag of honey-lemon contains 1.793 g. Of sugar, which corresponds to 0.15 XE.

In one bag of chamomile contains 2.058 g. Of sugar, which corresponds to 0.17 XE.

Form release / dosage:

Powder for the preparation of solution for ingestion of honey-lemon and chamomile.

Packaging:

By 5.0 g of powder in a bag of paper / Al / polyethylene.

1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, 16, 20, 30 bags in a cardboard box with instructions for use.

Storage conditions:

At a temperature of 10-30 ° C.

Keep out of the reach of children!

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-006587/09

Date of registration:18.08.2009 / 14.05.2015

Expiration Date:Unlimited

The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia

Manufacturer: & nbsp

NATUR PRODUKT PHARMA, Sp. z o.o. Poland

Representation: & nbspVALEANT LLC VALEANT LLC Russia

Information update date: & nbsp06.09.2017

Illustrated instructions

Instructions

Antigrippin (Antigrippin)