Acesol - instructions for use, doses, side effects, contraindications

Combined drug, has detoxification, plasma-substituting, rehydrating, diuretic, anti-shock, antiaggregant effect. Has a hemodynamic effect, reducing hypovolemia, preventing blood clotting and development of metabolic acidosis, improves capillary blood circulation, increases diuresis.

Pharmacokinetics:

Pharmacokinetics. Iones K⁺ and Na⁺ short-lived in the vascular bed, quickly distributed throughout the body tissues. Excreted mainly by the kidneys, in small amounts - through the intestine, then, with tears, etc.

In the body, acetate is activated in acetyl-coenzyme A (acetyl-CoA), then the main amount of active acetate is completely oxidized in the Krebs cycle to carbon dioxide and water. The oxidation of acetate is carried out in muscle cells, so the ability of the body to metabolize it is largely dependent on the muscle mass of the body. Metabolism of acetyl-CoA can also go along a small pathway of oxidation with the formation of fatty acids, keto acids and cholesterol.

Indications:

Dehydration, intoxication on the background of dehydration (including cholera, acute shigellosis, food poisoning).

Contraindications:

Hypersensitivity, hyperkalemia, chronic renal and heart failure, alkalosis, the presence of contraindications to the introduction of large quantities of liquid into the body.

Carefully:Not described.

Pregnancy and lactation:

The experience of using the drug during pregnancy and lactation is absent.

Dosing and Administration:

Intravenously (struino and drip), under the control of laboratory indicators. With severe dehydration, for 1 hour, inject a solution in an amount corresponding to 7-10% of the body weight of the patient; then the jet infusion is replaced by a dropwise addition, within 24-48 hours, at a rate of 40-120 cap / min. The volume of the injected solution is selected individually, in an amount necessary to restore the water-electrolyte balance. The balance of injected and lost fluid is determined every 6 hours.

The drug is used only for moderate and severe conditions, if oral rehydration is not possible.

Side effects:

Edema, tachycardia, hyperkalemia. In some cases, chills may occur.

Overdose:

Hyperkalemia, hypernatremia, hyperchloremia, metabolic alkalosis, volume overload.

When symptoms of an overdose occur, the drug is canceled.When the phenomenon of hyperkalemia, the drug is replaced with a solution of "Disol" until the electrolyte balance is normalized. If necessary, hemodialysis and peritoneal dialysis are performed.

Interaction:

Negative effects in the interaction with other drugs have not been established.

Special instructions:

Before administration, the solution is heated to 36-38 ° C. Therapy is carried out under the control of hematocrit and the concentration of blood electrolytes. In the case of hyperkalemia, the drug can be replaced with a solution of "Disol" until the electrolyte balance is normalized. In general, with the dehydration, the introduction of special solutions is shown inside, and only when this is impossible (indomitable vomiting, severe dehydration, severity of general condition, etc.), the drug is administered parenterally.

Effect on the ability to drive transp. cf. and fur:Data are not available due to the use of the drug solely in a hospital.

Form release / dosage:

Solution for infusion.

Packaging:For 100, 200, 250, 400, 500 ml in glass bottles.

For 100, 250, 500 ml in polymer containers.

Each polyvinyl chloride container is placed in a bag of polyethylene film.1 bottle with instructions for medical use in a pack of cardboard.

For 15 bottles with a capacity of 450 or 500 ml or 28 bottles with a capacity of 100 or 250 ml with the appropriate number of instructions for medical use placed in a box of corrugated cardboard (for hospitals).

A container with a capacity of 100 ml or 34 containers (a container bag) of 250 ml capacity or 22 containers (a container bag) of 500 ml capacity with appropriate number of instructions for medical use is placed in a box of corrugated cardboard (for hospitals ).

Storage conditions:

At a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N001120 / 01

Date of registration:03.02.2012

Expiration Date:Unlimited

The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia

Manufacturer: & nbsp

ESKOM NPK, OAO Russia

Information update date: & nbsp03.10.2017

Illustrated instructions

Instructions

Acesol (Acesol)