Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
АТХ:B.05.B.B.01 Electrolytes
Pharmacodynamics:Elimination of acidosis and normalization of water-electrolyte composition of blood: replenishment of loss of sodium and potassium salts, chloride ions, bicarbonates.
Plasma-replacing, rehydrating, anti-shock effect: temporary increase in the volume of circulating blood, reimbursement of salts of sodium, potassium, chloride ions, acetate ion.
Normalization of acid-base state (elimination of metabolic acidosis) and water-electrolyte blood composition: alkalizing effect (in metabolic acidosis); conversion of the acetate ion to bicarbonate.
Diuretic action.
Antiaggregant effect: reduces viscosity and improves rheological properties of blood.
Disintoxication action.
Improvement of microcirculation.
Pharmacokinetics:
Not studied. Acetate and gluconate ions are converted to hydrocarbonate ions. Excretion by the kidneys, a small amount - sweat glands.
Indications:Rehydration, intoxication on the background of dehydration (including cholera, acute dysentery, food poisoning).
I.A00-A09.A00 Cholera
I.A00-A09.A03.9 Shigellosis, unspecified
I.A00-A09.A03.8 Other shigellosis
I.A00-A09.A03.3 Shigellosis caused by Shigella sonnei
I.A00-A09.A03.2 Shigellosis caused by Shigella boydii
I.A00-A09.A03.1 Shigellosis caused by Shigella flexneri
I.A00-A09.A03.0 Shigellosis caused by Shigella dysenteriae
I.A00-A09.A05 Other bacterial food poisoning
I.A00-A09.A09 Diarrhea and gastroenteritis of allegedly infectious origin
IV.E70-E90.E86 Reduction of the volume of the liquid
Contraindications:Hypersensitivity, hyperkalemia, hyperchloremia, alkalosis, the presence of contraindications to the introduction of large amounts of fluid in the body, chronic renal failure.
Carefully:For sodium chloride: arterial hypertension, heart failure, peripheral edema or pulmonary edema, renal failure, preeclampsia, other conditions associated with retention of sodium ions.
For potassium chloride: heart disease and conditions predisposing to hyperkalemia (eg, kidney failure), acute dehydration, massive damage to tissues, for example, with severe burns. It is necessary to regularly monitor the clinical state, the content of electrolytes in the blood serum, ECG.
Pregnancy and lactation:Adequate and well-controlled studies in humans and animals have not been conducted. There is no information on the penetration into breast milk.
Action category for the fetus by FDA - AT.
The category of FDA recommendations for the combination is not defined.
Dosing and Administration:In severe forms of the disease - intravenously struino for 1-3 hours, with light forms - intravenously drip at a rate of 40-120 drops per minute for 24-48 hours. The volume of the solution must be selected individually, until the water-electrolyte balance is restored.
Side effects:Edema, tachycardia, hyperkalemia. Rarely - chills.
Interaction:Dextrose is a decrease in the concentration of potassium ions in the blood serum.
Drugs that help increase the concentration of potassium ions in the blood (eg, potassium-sparing diuretics, ACE inhibitors; ciclosporin; potassium-containing drugs and nutritional supplements) - the risk of hyperkalemia.
Non-steroidal anti-inflammatory drugs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators or ganglion blockers - sodium retention in organism.
Special instructions:A careful monitoring of the electrolyte content in the blood plasma is necessary.
The composition of the solution includes sodium chloride - 4.75-5 g, potassium chloride - 1-1.5 g, sodium acetate - 2-3.6 g, water for injections up to 1 liter.
Before use, the solution must be heated to body temperature (36-38 ° C).
Monitoring: hematocrit and concentration of electrolytes in blood serum.