Chlossol (Chlosol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePotassium chloride + Sodium acetate + Sodium chloridePotassium chloride + Sodium acetate + Sodium chloride
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    • Dosage form: & nbspsolution for infusions
    Composition:

    Active substances: sodium acetate trihydrate 3.6 g, sodium chloride 4.75 g, potassium chloride 1.5 g.

    Excipient: water for injection - up to 1 l Theoretical osmolarity ~ 291 mOsm / l

    Description:Colorless transparent liquid.
    Pharmacotherapeutic group:rehydrating agent.
    ATX: & nbsp

    B.05.B.B.01   Electrolytes

    Pharmacodynamics:

    Hemodynamic. Reduces hypovolemia, blood thickening and metabolic acidosis, improves capillary circulation, exerts detoxification effect.

    Combined saline solution has detoxification, plasma-substituting, rehydrating, diuretic, anti-shock, antiaggregant effect. Reduces hypovolemia, prevents blood clots and the development of metabolic acidosis, increases diuresis, improves microcirculation.

    Pharmacokinetics:

    Indications:

    Dehydration, intoxication on the background of dehydration (acute shigellosis, food toxicoinfection, cholera).

    Contraindications:

    Hypersensitivity, hyperkalemia, alkalosis, chronic renal and heart failure, the presence of contraindications to the introduction of large quantities of liquid into the body.

    Carefully:

    The solution of the drug is prescribed with caution to pregnant women and mothers breastfeeding.

    Large volumes of solution should be used with caution in patients with impaired renal excretory function.
    Pregnancy and lactation:

    The use of the drug is permissible if the expected benefit to the mother exceeds the potential risk to the fetus and the baby.

    Dosing and Administration:

    Intravenously (struino and drip).

    The drug is used only for moderate and severe conditions when it is impossible to take solutions for oral rehydration.

    Doses and the speed of administration are set individually, depending on the indications and the patient's condition, in an amount necessary to restore the water-electrolyte balance but not less than 1 liter; Children are injected at least 15 ml / kg. In severe forms of diseases, Chlozole is administered for 1-3 h / in struyno; then the jetting of adults is replaced by a drop; for 24-48 hours at a rate of 40-120 cap / min; children - in a dose of 20-25 ml / kg.

    When severe intoxication in adults, the drug is administered at a dose of up to 2-3 l / day in combination with other detoxification preparations; in children - 30-35 ml / kg / day.

    The drug solution is administered in amounts necessary to restore the volume of fluid lost with feces, vomiting, urine, sweat.

    The balance of injected and lost fluid is determined every 6 hours.

    Side effects:

    Edema, tachycardia, chills, hyperkalemia.

    Overdose:An early sign of potassium intoxication is paresthesia. Sometimes there can be a paradoxical reaction - an increase in the number of extrasystoles. In these cases, the drug is replaced with Sodium Acetate + Sodium Chloride & until the electrolyte balance is normalized.
    Interaction:It can be used in combination with colloidal solutions (drugs, decks, Potassium chlorideCalcium chloride+ Magnesium chloride +Sodium bicarbonateSodium chloride+ Povidone-8tys. &, Gelatin & etc.); it is also compatible with donor blood-curd / erythromassa, plasma and other blood preparations. Do not interfere with the appointment of commonly used anti-shock drugs, including. drugs for neuroleptanalgesia (fentanyl, droperidol), benzodiazepines (diazepam , etc.), as well as muscle relaxants (suxamethonium hydrochloride, etc.), inhibitors of proteolysis (aprotinin) and alpha-adrenomimetics (dopamine, epinephrine).
    Special instructions:

    In the general case, during the dehydration, the administration of solutions is indicated by mouth, and only when this is not possible (for one reason or another), the drugs are administered parenterally.

    Before use, the solution must be heated to body temperature. The treatment is carried out under the control of hematocrit, and the concentration of electrolytes of blood, arterial pressure, electrocardiogram, diuresis.

    In the case of hyperkalemia, the drug is replaced with Sodium Acetate + Sodium Chloride & until the electrolyte balance is normalized.

    Effect on the ability to drive transp. cf. and fur:Data are not available due to the exclusive use of the drug in a hospital setting.
    Form release / dosage:

    Solution for infusion. 100, 200, 400 ml in glass bottles for blood, infusion and transfusion preparations with a capacity of 100, 250 or 450 ml, respectively, sealed with rubber stoppers and crimped with aluminum caps.

    The label is labeled with a label or writing paper on the bottle. EveryoneI blow the bottle, together with the instructions for use, put in a pack of cardboard for consumer containers.
    56 bottles of, 100 ml, 24, 28 bottles of 200 ml and 12, 15 bottles of 400 ml respectively, are placed in boxes of cardboard corrugated with nested instructions for use equal to the number of bottles (for the stadiumditch).

    100, 200, 250, 400, 500.1000 ml into bags of polyolefin film.

    For each package of polyolefin film, a self-adhesive label is glued or the text of the label is applied by hot stamping, using thermal printing. It is allowed to apply the text of the instructions for use directly to the package by hot stamping, thermal printing or a self-adhesive label.

    56 bags of 100 ml, 24, 28 packages of 200 or 250 ml, 12, 15 packages of 400 or 500 ml, 12 packages of 1000 ml are placed in boxes of cardboard corrugated together, with instructions for use in an amount equal tothe cost of packages (for the station).

    Storage conditions:

    In a dry place inaccessible to children at a temperature not exceeding 25 FROM.

    Shelf life:

    2 years. After the expiry date indicated on the package, the preparation does not use.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001514
    Date of registration:29.07.2011
    The owner of the registration certificate:BIOCHEMIST, OJSC BIOCHEMIST, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp29.07.2011
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