Aevit - instructions for use, doses, side effects, contraindications

active substances: retinol palmitate [Vitamin A-palmitate oily form, 1.0 million IU / g or 1.7 million IU / g (containing in 1 g: retinol palmitate - 1,000,000 IU, butyl hydroxytoluene - 10 mg, sunflower oil - up to 1 g or retinol palmitate - 1 700 000 ME, butylhydroxytoluene - 17 mg, sunflower oil-up to 1 g)] - 0.055036 g (100000 ME), alpha-tocopherol acetate - 0.1 g (100 IU);

Excipients: sunflower oil (sunflower oil refined deodorized) - up to 0.2 g;

composition of the shell: gelatin - 0.036913 g, glycerol (glycerol) -0.011865 g, methyl parahydroxybenzoate (nipagin) - 0.000264 g, natural instant coffee -0.000958 g.

Description:

The drug is well absorbed from the digestive system. With a current of lymph and blood is transported to organs and tissues. Excess vitamins A and E accumulate mainly in the liver. Unchanged, vitamins A and E can be secreted into the intestinal lumen with bile, in an altered form, excreted from the body with urine and feces.

Pharmacotherapeutic group:Multivitamins

ATX: & nbsp

A.11.H.A.03 Tocopherol (vitamin E)

Pharmacodynamics:

It replenishes the deficiency of retinol and vitamin E.

Retinol (vitamin A) is necessary for bone growth, normal reproductive function, embryonic development, for regulation of epithelial division and differentiation (enhances the division of skin epithelial cells, rejuvenates the cellular population, inhibits keratinization processes). Vitamin A takes part as a cofactor in various biochemical processes.

The function of alpha-tocopherol (vitamin E) remains unclear until the end. As an antioxidant, inhibits the development of free radical reactions, prevents the formation of peroxides damaging cell membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. Together with selenium, it inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transfer system), prevents the hemolysis of erythrocytes. It is a cofactor of some enzyme systems.

Pharmacokinetics:

The drug is well absorbed from the digestive system. With a current of lymph and blood is transported to organs and tissues. Excess vitamins A and E accumulate mainly in the liver.Unchanged, vitamins A and E can be secreted into the intestinal lumen with bile, in an altered form, excreted from the body with urine and feces.

Indications:

Combined avitaminosis A and E.

Contraindications:

Hypersensitivity, hypervitaminosis A and E, pregnancy and the period of breastfeeding, children's age (under 14 years).

Carefully:Thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (chronic heart failure, chronic glomerulonephritis, etc.), liver cirrhosis, viral hepatitis, renal insufficiency, alcoholism, advanced age, hypoprothrombinemia (against a background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 ME).

Pregnancy and lactation:The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:

Inside, regardless of food intake, daily 1 capsule per day.

The duration of treatment is 20-40 days.

Side effects:

Allergic reactions, (including skin rash), pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea). With prolonged use in large doses, an exacerbation of cholelithiasis and chronic pancreatitis may occur.

Overdose:

Symptoms of an acute overdose of vitamin A (develop through 6 h byfromlevitaminosis A: in adults - drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration of the oral mucosa, exfoliation of the lips, skin ( especially palms), excitement, confusion.

Symptoms of chronic intoxication with vitamin A: anorexia, bone pain, cracks and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, nasolabial triangle, hepatotoxic phenomena, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in bone radiographs, seizures; fetotoxic phenomena: in humans - malformations of the urinary system, growth retardation. Early closure of epiphyseal growth zones.

Symptoms of an overdose of vitamin E: when taken for a long period in doses of 400-800 IU / day - blurred vision, dizziness, headache,nausea, diarrhea, gastralgia, asthenia; when taking more than 800 IU / day for a long period - an increase in patients with hypovitaminosis risk of bleeding K metabolism disorders of the thyroid hormones, sexual function disorders, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, bleeding in the mesh a covering of an eye, a hemorrhagic stroke, an ascites.

Treatment: drug cancellation; symptomatic therapy.

Interaction:

Vitamin A weakens the effect of calcium supplementation increases the risk of hypercalcemia.

Kolestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A and E (may require raising their dose). Oral contraceptives increase the concentration of vitamin A in the plasma.

Isotretinoin increases the risk of intoxication with vitamin A.

The simultaneous use of tetracycline and vitamin A in high doses (50 tys.ME or higher) increases the risk of intracranial hypertension.

Vitamin E increases the effect of corticosteroids, nonsteroidal anti-inflammatory drugs, antioxidants, vitamins increases efficiency A, D, cardiac glycosides. The appointment of vitamin E in high doses can cause vitamin A deficiency in the body.

Simultaneous use of vitamin E at a dose of more than 400 IU / day with anticoagulants (coumarin and indanedione derivatives) increases the risk of hypoprothrombinemia and bleeding.

Special instructions:

To avoid the development of hypervitaminosis A and E, do not exceed recommended doses.

When using the drug should take into account the large content in it of vitamin A (100 thousand. ME), and also that it is a curative and not a preventive medicine.

A diet with an increased content of selenium and sulfur-containing amino acids reduces the need for vitamin E.

Effect on the ability to drive transp. cf. and fur:

Admission of the drug does not affect the ability to drive vehicles and to engage in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:

Capsules.

Packaging:

25 capsules per can of polymeric materials.

10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil.

The bank or 1, 2, 3, 5 or 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard for consumer containers.

150 contour mesh packages with an equal number of instructions for use are placed in a carton box box (for hospitals).

Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002589

Date of registration:19.08.2014

Expiration Date:19.08.2019

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp04.02.2017

Illustrated instructions

Instructions

Aevit (Aevit)