Aevit - instructions for use, doses, side effects, contraindications

Active substanceVitamin E + RetinolVitamin E + Retinol

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MELIGEN FP, CJSC Russia

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MARBIOFARM, OJSC Russia

Dosage form: & nbspcapsules

Composition:

One capsule contains:

Active substances: alpha-tocopherol acetate (vitamin E) 100.00 mg, retinol palmitate (vitamin A) 55.00 mg (100,000 ME).

Excipients: sunflower oil 45.00 mg, gelatin 44.73 mg, glycerol 14.67 mg, methyl parahydroxybenzoate 0.29 mg, sugar color 0.31 mg.

Description:

Soft gelatin capsules are spherical in shape from yellow to light brown, filled with oily liquid from light yellow to dark yellow color, without a rancid smell.

Pharmacotherapeutic group:Multivitamins

ATX: & nbsp

A.11.H.A.03 Tocopherol (vitamin E)

Pharmacodynamics:

Combined drug, the effect of which is determined by the properties of the constituent vitamins A and E. Retinol (vitamin A) is involved in the formation of visual pigments necessary for normal twilight and color vision; ensures the integrity of epithelial tissues, regulates the growth of bones.

Tocopherol (vitamin E) has antioxidant properties (removes toxins from the body),provides protection of unsaturated fatty acids; participates in the formation of intercellular substance, collagen and elastic fibers of connective tissue, smooth musculature of vessels, digestive tract.

It restores impaired capillary circulation, normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

Pharmacokinetics:

Retinol is absorbed in the gastrointestinal tract after emulsification with bile acids. It is metabolized in the liver. Metabolites of retinol are secreted by bile (retinyl palmitate, retinal, retinoic acid) and urine (retinoylglucuronide). Elimination of retinol is slow, cumulation is possible.

Vitamin E: About 50% of the dose is slowly absorbed from the gastrointestinal tract, the maximum level in the blood is detected after 4 hours. Deposited in the adrenal glands, testes, fat and muscle tissue, red blood cells, liver. Isolated from the body in an unchanged form and in the form of metabolites with bile (more than 90%) and urine (about 6%).

Indications:

Combined avitaminosis A and E.

In complex therapy:

- lesions and skin diseases accompanied by trophic tissue disorders (psoriasis, some forms of eczema, ichthyosis, seborrheic dermatitis).

Contraindications:

Increased hypersensitivity to the components of the drug, hypervitaminosis A and / or E, children's age (under 18 years), the drug is contraindicated in pregnancy and lactation.

Carefully:

Thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, cholecystitis, chronic pancreatitis. The drug should not be taken with other medicines, and the composition of which includes vitamins A and E.

Dosing and Administration:

Apply only on doctor's recommendation

Inside, 1 capsule per day, regardless of food intake. The course of treatment is 30-40 days. It is possible to conduct repeated courses on the recommendation of a doctor.

Side effects:

Allergic reactions (skin rash), a feeling of discomfort in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea). With prolonged admission, exacerbation of cholelithiasis and chronic pancreatitis may occur.

Overdose:

Symptoms of an acute overdose of vitamin A (develop 6 hours after the administration): drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, gingival bleeding, dryness and ulceration of the oral mucosa, exfoliation of the lips, skin (especially the palms), agitation, confusion, increased intracranial pressure (in infants - hydrocephalus, protrusion of the fontanel).

Symptoms of chronic intoxication with vitamin A: anorexia, bone pain, cracks and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, in the region of the nasolabial triangle, hepatotoxic phenomena,wintraocular pressure, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in radiographs of bones, convulsions.

Symptoms of an overdose of vitamin E: when taken for a long period at doses of 400-800 U / day - blurred vision, dizziness, headache, nausea, diarrhea,gastralgia, asthenia; when taking more than 800 IU / day for a long period - an increase in patients with hypovitaminosis risk of bleeding K metabolism disorders of the thyroid hormones, sexual function disorders, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, bleeding in the mesh a covering of an eye, a hemorrhagic stroke, an ascites.

Treatment: discontinuation of the drug; symptomatic therapy.

Interaction:

Vitamin A increases the risk of hypercalcemia. Kolestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A and E (may need to increase their dose). Oral contraceptives increase the concentration of vitamin A in the plasma. Isotretinoin It increases the risk of intoxication of vitamin A. The simultaneous use of tetracycline and vitamin A in high doses (50 thousand. ED or higher) increases the risk of intracranial hypertension.

Vitamin E increases the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants, increases efficacy and reduces the toxicity of vitamins A, D, cardiac glycosides.The appointment of vitamin E in

high doses can cause vitamin A deficiency in the body. Simultaneous use of vitamin E at a dose of more than 400 units / day with anticoagulants (coumarin and indanedione derivatives) increases the risk of hypoprothrombinemia and bleeding. High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Special instructions:

To avoid the development of hypervitaminosis A and E, do not exceed the recommended dose. When using the drug should take into account the high content in it of vitamin A (100 thousand. ME). A diet with an increased content of selenium and sulfur-containing amino acids reduces the need for vitamin E.

Effect on the ability to drive transp. cf. and fur:

Data on the negative effect of the drug in the recommended doses on the ability to drive vehicles and work with mechanisms there.

Form release / dosage:

Capsules.

Packaging:

10 capsules in a planar cell package.

By 2, 3, 4 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

For hospitals.

1, 2, 3, 4, 5, 10, 20, 50, 100, 200, 400, 600 contour cell packs together with an equal number of instructions forthe application is placed in a polyethylene hermetically sealed bag of opaque polyethylene film, or of a material combined on paper and cardboard basis, or from a combined "Bufleen" material or a two-layer composite material. It is allowed to apply instructions for use on the package.

Polyethylene packages and packs are placed in a cardboard box, or from cardboard box, or from cardboard recycled paper.

50, 100, 200, 400, 600 contour squares, together with an equal number of instructions for use, are placed in a cardboard box, either from cardboard box, or from recycled cardboard.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-002467

Date of registration:20.05.2014

Expiration Date:20.05.2019

The owner of the registration certificate:MELIGEN FP, CJSC MELIGEN FP, CJSC Russia

Manufacturer: & nbsp

MELIGEN FP, CJSC Russia

Information update date: & nbsp04.02.2017

Illustrated instructions

Instructions

Aevit (Aevit)