Aevit (Aevit)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceVitamin E + RetinolVitamin E + Retinol
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  • Aevit
    capsules inwards 
    MINSKINTERKAPS, UP     Republic of Belarus
  • Aevit
    capsules inwards 
    ALTAYVITAMINS, CJSC     Russia
  • Aevit
    capsules inwards 
    LYUMI, LLC     Russia
  • Aevit
    capsules inwards 
    MELIGEN FP, CJSC     Russia
  • Aevit
    capsules inwards 
    MARBIOFARM, OJSC     Russia
    • Dosage form: & nbspcapsules
    Composition:

    1 capsule

    Active substances:

    Alpha-tocopherol acetate (vitamin E) 100 mg

    Retinol palmitate (vitamin A) * 100,000 IU

    Excipients:

    Soybean oil up to 200 mg

    The composition of the shell in terms of absolutely dry matter:

    Gelatine 52.75 mg

    Glycerol 16.80 mg

    Methylparahydroxybenzoate 0.45 mg

    * Composition 1.7 million IU / g

    Vitamin A palmitate - 990 mg

    d, 1 -alpha-tocopherol acetate-10 mg

    Description:

    Capsules are spherical in shape from yellow to light brown, filled with oily liquid from light yellow to dark yellow without a rancid odor.

    Pharmacotherapeutic group:Multivitamins
    ATX: & nbsp

    A.11.H.A.03   Tocopherol (vitamin E)

    Pharmacodynamics:

    Combined drug, the effect of which is determined by the properties of its constituent fat-soluble vitamins A and E.

    Retinol (vitamin A) - is necessary for the regulation of epithelial division and differentiation
    (enhances the division of skin epithelial cells, rejuvenates the cellular population,

    inhibits the processes of keratinization, takes part as a cofactor in various biochemical processes.

    Alfa-tocopherol (vitamin E) - has antioxidant properties, inhibits the development of free radical reactions, prevents the formation of peroxides damaging cell membranes, which is important for the development of the body, the normal function of the nervous and muscular systems. It is a cofactor of some enzyme systems. Normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

    Pharmacokinetics:

    Retinol palmitate is well absorbed in the upper parts of the small intestine, penetrates the lymphatic pathways and enters the liver. After administration, the maximum plasma concentration is reached after 4 hours. Retinol is distributed unevenly in the body. The greatest number is in the liver and retina, it is found in the kidneys, adrenal glands and other glands of internal secretion. Retinol metabolites are secreted by the kidneys. The half-life of 9.1 hours.

    Alpha-tocopherol acetate is absorbed in the gastrointestinal tract, most of it enters the lymph, quickly spreads in all tissues, is secreted with bile and in the form of metabolites with urine.

    Indications:

    Avitaminosis A, E.

    In complex therapy:

    - lesions and skin diseases accompanied by trophic tissue disorders (psoriasis, some forms of eczema, ichthyosis, seborrheic dermatitis).
    Contraindications:

    Hypersensitivity to the components of the drug, hypervitaminosis A and / or E, children's age (under 18 years), pregnancy, lactation.

    Carefully:

    Thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (chronic heart failure, chronic glomerulonephritis, etc.), liver cirrhosis, viral hepatitis, renal insufficiency, alcoholism, advanced age, hypoprothrombinemia (against a background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 ME).

    With prolonged use in large doses, an exacerbation of cholelithiasis and chronic pancreatitis may occur.

    Dosing and Administration:

    Apply only on the advice of a doctor.

    Inside, regardless of food intake, 1 caps / day.

    The course of treatment - 20-40 days at intervals of 3-6 months.

    It is possible to conduct repeated courses on the recommendation of a doctor.

    Side effects:

    Allergic reactions (including skin rash), pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea).

    Overdose:

    Symptoms of an acute overdose of vitamin A (develop 6 hours after the administration): drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, gingival bleeding, dryness and ulceration of the oral mucosa, exfoliation of the lips, skin (especially the palms), agitation, confusion.

    Symptoms of chronic intoxication with vitamin A: anorexia, bone pain, cracks and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, nasolabial triangle, hepatotoxic effects, increased intraocular pressure, oligomenorrhoea, portal hypertension, hemolytic anemia, changes in bone radiographs, convulsions.

    Symptoms of an overdose of vitamin E: when taken for a long period in doses of 400-800 units / day - blurred vision, dizziness, headache, nausea, diarrhea, gastralgia,asthenia; when taking more than 800 units / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a sexual function disorder, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, bleeding in the mesh a covering of an eye, a hemorrhagic stroke, an ascites.

    Treatment: drug cancellation; symptomatic therapy.

    Interaction:

    Vitamin A increases the risk of hypercalcemia.

    Kolestyramine, colestipol, mineral oils, neomycin reduce the absorption of vitamin A and E (may need to increase their dose).

    Oral contraceptives increase the concentration of vitamin A in the plasma. Isotretinoin increases the risk of intoxication with vitamin A.

    Simultaneous use of tetracycline and vitamin A in high doses (50 thousand AD and above) increase the risk of developing intracranial hypertension.

    Vitamin E enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, antioxidants, increases efficacy and reduces toxicity of vitamins A, D, cardiac glycosides.

    The appointment of vitamin E in high doses can cause vitamin A deficiency in the body. Vitamin E increases the effectiveness of antiepileptic drugs in patients with epilepsy (which have increased blood levels of products of lipid peroxidation). Simultaneous use of vitamin E at a dose of more than 400 units / day with anticoagulants (coumarin and indanedione derivatives) increases the risk of hypoprothrombinemia and bleeding.

    High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

    Special instructions:

    To avoid the development of hypervitaminosis A and E, do not exceed the recommended dose.

    When using the drug should take into account the high content in it of vitamin A (100 thousand. ME), and also that it is a curative and not a preventive medicine.

    A diet with an increased content of selenium and sulfur-containing amino acids reduces the need for vitamin E.

    Form release / dosage:

    Capsules.

    Packaging:

    10 capsules per contour cell packaging of polyvinylchloride film and paper with a polymer coating or foil of aluminum printed lacquered.

    By 2, 3, 4 contour mesh packages along with the instruction for use are placed in a pack of chromium-ersatz cardboard or cardboard box.

    1, 2, 3, 5, 10, 20, 50 contour mesh packages, together with an equal number of instructions for use, are placed in a polyethylene hermetically sealed bag of lightproof polyethylene film, or of a material combined on paper and cardboard basis, or from a combined " Buflen ", or from a two-layer combined material.

    50, 100, 200, 400, 600 contour mesh packages together with an equal number of instructions for use are placed in a sealed polyethylene hermetically sealed bag of light-tight polyethylene film.

    It is allowed to apply instructions for use on the package.

    Polyethylene packaging is placed in a cardboard box.

    For hospitals 50, 100, 200, 400, 600 contour cells, together with the instruction for use, are placed in a cardboard box.

    Storage conditions:

    In dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N001776 / 01-2002
    Date of registration:21.11.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:LYUMI, LLC LYUMI, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp04.02.2017
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