Symptoms of an acute overdose of vitamin A (Occurring at 6 hours after administration) in adults - drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, pernicious vomiting, diarrhea, irritability, osteoporosis, bleeding gums, dryness and ulceration of the oral mucosa, peeling lips, skin (especially the palms), agitation, confusion, increased intracranial pressure; in infants - hydroencephaly, protrusion of the fontanel.
Symptoms of chronic intoxication with vitamin A: anorexia, bone pain, cracks and dry skin, lips, dryness of the oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, in the nasolabial triangle, hepatotoxic effects, increased intraocular pressure, oligomenorrhea, portal hypertension, haemolytic anemia, bone changes on radiographs, convulsions; fetotoxic phenomena: in humans - malformations of the urinary system, growth retardation,early closure of epiphyseal growth zones; in animals - malformations of the central nervous system, spine, thorax, heart, eyes, upper sky, urogenital system.
Symptoms of an overdose of vitamin E: when taken for a long period in doses of 400-800 units / day - blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 units / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a sexual function disorder, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, bleeding in the mesh a covering of an eye, a hemorrhagic stroke, an ascites.
Treatment: drug cancellation; symptomatic therapy.