Symptoms of acute overdose (develop 6 hours after admission): hypervitaminosis A: adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, indomitable vomiting, diarrhea, irritability, bleeding gums, dryness and ulceration of the oral mucosa, peeling lips, skin (especially the palms), confusion, increased intracranial pressure (in infants - hydrocephalus, protrusion of the fontanel).
Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dry skin, dryness of the oral mucosa, lips, gastralgia, vomiting, hyperthermia, asthenia, excessive fatigue, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss, yellow-orange spots on the soles, palms, in the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhea, portal hypertension,hemolytic anemia, changes in radiographs of bones, convulsions.
Treatment: drug cancellation; symptomatic therapy.
Symptoms of vitamin E overdose: when taken for a long period in doses of 400-800 units per day - blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 units per day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a sexual function disorder, thrombophlebitis, necrotic colitis, sepsis, hepatomegaly, hemorrhagic stroke, ascites.
Treatment: withdrawal of the drug, symptomatic therapy.