Dibikor - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Taurine is a natural product of the exchange of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane-protective properties, positively affects the phospholipid composition of cell membranes, normalizes the exchange of calcium and potassium ions in cells. In taurine, the properties of the inhibitory neurotransmitter are revealed, it possesses anti-stress action, it can regulate the release of gamma-aminobutyric acid (EAAM), epinephrine, prolactin and other hormones, and also to regulate the answers to them. By participating in the synthesis of respiratory chain proteins in mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties; affects enzymes, such as cytochromes, involved in the metabolism of various xenobiotics.

Dibicor ® improves metabolic processes in the heart, liver and other organs and tissues.In chronic diffuse diseases of the liver, Dibicor® increases blood flow and reduces the severity of cytolysis. Treatment with Dibicor® for cardiovascular failure (CVS) leads to a reduction in stagnant phenomena in small and large circles of the circulation: decreases intracardiac diastolic pressure, myocardial contractility increases (maximum rate of contraction and relaxation, indices of contractility and relaxation). The drug moderately reduces blood pressure (BP) in patients from arterial hypertension and virtually no effect on blood pressure in patients with cardiovascular failure with low blood pressure. Dibicor ® reduces side effects that occur when an overdose of cardiac glycosides and blockers of "slow" calcium channels; reduces hepatotoxicity antifungal drugs. Increases working capacity in severe physical exertion.

In diabetes, approximately 2 weeks after the start of taking Dibicor®, the concentration of glucose in the blood decreases. There was also a significant decrease in the concentration of triglycerides, to a lesser extent - the concentration of cholesterol, a decrease in the atherogenicity of plasma lipids.With prolonged use of the drug (about 6 months), there was an improvement in microcirculatory blood flow eyes.

Pharmacokinetics:

After a single dose of 500 mg of Dibicor®, the active ingredient taurine after 15 to 20 minutes is determined in the blood, reaching a maximum through 1,5-2 hours. Completely the drug is withdrawn after 24 hours.

Indications:

- cardiovascular - insufficiency of various etiology;

- intoxication caused by cardiac glycosides;

- Type 1 diabetes mellitus;

- Type 2 diabetes mellitus, including number and with moderate hypercholesterolemia.

- as hepatoprotector y patients, host antifungal drugs.

Contraindications:

- hypersensitivity to the drug;

- Dibicor® is not recommended for use in children under the age of 18 due to inadequate data on efficacy and safety.

If you have one of the listed diseases, always consult a doctor before taking the drug.

Pregnancy and lactation:

Dosing and Administration:

With heart failure, Dibicor® is ingested 250-500 mg ('/ g -1 tablet) 2 times a day 20 minutes before meals, and the course of treatment is 30 days.The dose can be increased to 2-3 g (4-6 tablets) per day.

In case of cardiac glycoside intoxication - not less than 750 mg (1.5 tablets) per day.

In type 1 diabetes, 500 mg (1 tablet) 2 times a day in combination with insulin therapy for 3-6 months.

With type 2 diabetes, 500 mg (1 tablet) 2 times a day in monotherapy or in combination with other hypoglycemic means for oral administration.

With type 2 diabetes mellitus, including with moderate hypercholesterolemia - 500 mg each (1 tablet) 2 times a day, The duration of the course is doctor's recommendations.

As hepatoprotector - 500 mg (1 tablet) 2 times a day for the entire course of taking antifungal drugs.

Side effects:

Allergic reactions to the components of the drug are possible.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:Data on overdose are absent.

Interaction:

Dibicor® can be used with other medicines; enhances the inotropic effect of cardiac glycosides.

Special instructions:Against the background of taking Dibicor®, the dose of cardiac glycosides should be reduced by a factor of 2, depending on the sensitivity of the patients to cardiac glycosides. The same rule applies to blockers of "slow" calcium channels.

Form release / dosage:

Tablets 500 mg.

10 tablets per contour cell pack.

3 or 6 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Packaging:(10) - packings, cellular, outline (3) - packs, cardboard
(10) - packings, cell planimetric (6) - packs cardboard

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:3 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000264

Date of registration:16.02.2011

The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia

Manufacturer: & nbsp

PIK-PHARMA, LLC Russia

Information update date: & nbsp05.09.2015

Illustrated instructions

Instructions

Dibicor® (Dibicor®)