Only for intravenous administration!
The dose is selected individually and depends on the degree of severity of the shock, the magnitude of the blood pressure, as well as on the patient's reaction to the therapy.
The duration of administration depends on the clinical situation and should be determined by the physician. The rate of injection should be selected individually to achieve the optimal response of the patient. If possible, administration should be performed through a central venous catheter.
The initial dose of the drug is recommended 2-5 μg / kg / min. In the case of a patient's severe condition, the initial dose should be 5 μg / kg / min. If necessary, it is possible to gradually increase the dose (every 15-30 minutes) by 5-10 μg / kg body weight per minute.
In most patients, it is possible to maintain a satisfactory condition with doses less than 20 μg / kg / min.Doses exceeding this value can lead to a decrease in renal function, a decrease in renal blood flow.
In the case of acute cardiovascular failure, cardiac decompensation Dopamine Admed is administered at a rate of more than 50 μg / kg / min.
Duration of application: the duration of infusions depends on the individual characteristics of the patient.
Dosage for drip administration (see table 1)
If the contents of 1 ampoule of Dopamine Admed 200 mg are dissolved in 50 ml of solution for injection, 1 ml of this solution contains 4000 μg of dopamine.
Table number 1
| Dosage | 50 kg of body weight | 70 kg of body weight | 90 kg of body weight |
| 2 μg / kg body weight / min | 1.5 ml / hr | 2.1 ml / hour | 2.7 ml / hr |
| 5 μg / kg body weight / min | 3.75 ml / hour | 5.25 ml / hr | 6.75 ml / hr |
| 10 μg / kg body weight / min | 7.5 ml / hr | 10.5 ml / hr | 13.5 ml / hr |
| 20 μg / kg body weight / min | 15.0 ml / hr | 21.0 ml / hr | 27.0 ml / hr |
| 50 μg / kg body weight / min | 37.5 ml / hr | 52.5 ml / hr | 67.5 ml / hr |
Dosages for infusion (hardware) (see Table 2)
If the contents of 1 ampule of Dopamine Admed 200 mg are dissolved in 500 ml of solution for injection, 1 ml of this solution contains 400 μg of dopamine.
Table number 2
| Dosage | 50 kg of body weight | 70 kg of body weight | 90 kg of body weight |
| 2 μg / kg body weight / min | 15 ml / hour (5 drops / min) | 21 ml / hour. (7 drops / min) | 27 ml / hour (9 drops / min) |
| 5 μg / kg body weight / min | 37.5 ml / hr (2.5 drops / min) | 52.5 ml / hr (17.5 drops / min) | 67.5 ml / hr (22.5 drops / min) |
| 10 μg / kg body weight / min | 75 ml / hr (25 drops / min) | 105 ml / hr (35 drops / min) | 135 ml / hr (45 drops / min) |
| 20 μg / kg body weight / min | 150 ml / hr (50 drops / min) | 210 ml / hr (70 drops / min) | 270 ml / hr (90 drops / min) |
| 50 μg / kg body weight / min | 375 ml / hr | 525 ml / hr | 675 ml / hr |
After the stabilization of the clinical situation, the drug is withdrawn gradually.
To enhance diuresis and obtain an inotropic effect (an increase in the contractile activity of the myocardium) is administered at a rate of 100-250 μg / min (1.5-3.5 μg / kg / min) (low dose region).
With intensive surgical therapy - 300-700 μg / min (4-10 μg / kg / min) (medium dose area); with septic shock - 750-1500 μg / min (10.5-21 μg / kg / min) (maximum dose area).
In order to influence the blood pressure it is recommended to increase the dose to 500 mcg / min or more, or at a constant dose of the drug Dopamine Admeda is additionally prescribed norepinephrine (norepinephrine) at a dose of 5 μg / min with a body weight of about 70 kg.
If there is a disturbance in the rhythm of the heart, regardless of the doses used, further increase in the drug is contraindicated.
Children injected at a dose of 4-6 (maximum 10) μg / kg / min. Unlike adults, in children the dose should be increased gradually, ie, starting with the lowest dose.
Duration of use: duration of infusions depends on the individual characteristics of the patient. There is a positive experience of infusion lasting up to 28 days.
Rules for the preparation of solution
For dilution use: 0.9% solution of sodium chloride, 5% solution of dextrose (glucose), Ringer-lactate solution.
Preparation of the infusion solution should be made immediately before use (the stability of the solution remains for 24 hours, except for the mixture with Ringer-lactate solution - a maximum of 6 hours). The drug Dopamine Admeda solution should be clear and colorless.