Enterofuril - instructions for use, dose, side effects, contraindications

Composition of the capsule shell (%): titanium dioxide (E 171) - 1.3333, dye chiNolin yellow (E 104) - 0.7664, the edgessieve azorubin (E 122) - 0.0022, beautifulCrimson Cow [Ponso 4R] - 0.0077 desiroustin - q.s. up to 100.

Dosing composition 200 mg:

1 capsule No. 0 contains:

Active substance: nifuroxazide 200,0 mg

Excipients: sucrose 68,0 mg, corn starch 65.90 mg, cellulose microcrystalline 9.0 mg, magnesium stearate 7.10 mg.

Composition of the capsule shell (%): titanium dioxide (E 171) - 2.95, iron dye oxide yellow (E 172) - 1.00, gelatin - q.s. up to 100.

Description:Hard gelatinous opaque capsules yellow (dosage 100 mg - № 2) and brownish (dosage 200 mg - No. 0) Colors filled with powder yellow, or yellow powder colors with inclusions in the form of small pieces of compressed mass, or pressed yellow powderone that crumbles with a lung click.

Pharmacotherapeutic group:Antimicrobial agent, nitrofuran.

ATX: & nbsp

A.07.A.X.03 Nifuroxazide

Pharmacodynamics:

Antimicrobial agent of a wide range of actionsth derivative of 5-nitrofuran. It is assumed that the antimicrobial activity of nifuroxazide is caused by the presence in its composition NO₂- groups, which causes inhibition of dehydrogenase activity and disrupts the synthesis of proteins in pathogenic bacteria.

Active against gram-positive microorganisms (Streptococcus aureus, Staphylococcus pyogenes, Clostridium), Gram-negative enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Campylobacter jejuni, Edwarsiella, Citrobacter, Yersinia enterocolitica).

Nifuroxazide has no effect on saprophyte flora, does not disturb the balance of normal intestinal flora. With acute bacterial diarrhea, eubiosis of the intestine is restored. When infected with enterotrophic viruses prevents the development of bacterial superinfection.

Pharmacokinetics:

After oral administration, nifuroxazId is practically not absorbed from the digestive tract, and its antibacterial action exerts exclusively in the lumen of the intestine. Completely eliminated through the gastrointestinal tract. The rate of elimination depends both on the dose of the drug and on the motility of the intestinal tract.

Indications:Diarrhea of bacterial origin

Contraindications:

- Increased sensitivityto derivatives of nitrofuran or other components of the preparation;

- Children up to 3 years (for this dosage form).

- Intolerance to fructose, glucose-galactose malabsorption syndrome, insufficiency of sugar and isomaltase.

Pregnancy and lactation:The use of Enterofuril® during pregnancy is possible only in cases when the expected benefit of therapy for the mother exceeds the potential risk to the fetus.Enterofuril® is not absorbed from the gastrointestinal tract and does not enter the systemic circulation, however, the use of the drug during lactation is possible only on strict indications, at the same time it is necessary to resolve the issue of stopping breastfeeding.

Dosing and Administration:

It is applied inside.

Capsules 100 mg:

Adults and children over 7 years: 2 capsules x 4 times a day (200 mg x 4 times a day, total 800 mg nifuroxazide / day)

Children 3-7 years: 2 capsules x 3 times a day (200 mg x 3 times a day, total 600 mg nifuroxazide / day)

Capsules 200 mg:

Adults and children over 7 years: 1 capsule x 4 times a day (total 800 mg nifuroxazide / day)

Children 3-7 years: 1 capsule x 3 times a day (200 mg x 3 times a day, only 600 mg nifuroxazide / day).

Nifuroxazide therapy should not last more than 7 days.

Side effects:

Nausea, vomiting, allergic reactions (rash, hives, swelling Quincke, anaphylactic shock).

Overdose:The drug is not absorbed from the gastrointestinal tract and does not enter the systemic circulation. Symptoms of overdose are unknown. In case of exceeding the dose, gastric lavage and symptomatic treatment are recommended.

Interaction:

There is no evidence that nifuroxazide interacts with other drugs.

Special instructions:When treating diarrhea concomitantly with nifuroxazide therapy, it is necessary to conduct rehydration therapy (oral or intravenous) in accordance with the patient's condition and the intensity of diarrhea.

During therapy, the use of alcohol is prohibited, since it increases

sensitivity of the organism to nifuroxazide.

If symptoms of hypersensitivity (dyspnea, rash, itching) appear, stop taking the drug.

Effect on the ability to drive transp. cf. and fur:The drug does not affect the psychomotor activity, the ability to drive vehicles and work with mechanisms.

Form release / dosage:

Capsules.

Packaging:

Dosage of 100 mg

10 capsules per blister of PVC film and aluminum foil.For 3 blisters with instructions for use are placed in a cardboard box.

Dosage 200 mg

For 8 capsules in a blister of PVC film and aluminum foil. For 2 or 4 blisters with instructions for use are placed in a cardboard box.

Storage conditions:

At a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:П N014624 / 01

Date of registration:31.10.2008

The owner of the registration certificate:Boznalek, AOBoznalek, AO Bosnia and Herzegovina

Manufacturer: & nbsp

BOSNALIJEK, d.d. Bosnia and Herzegovina

Representation: & nbspBOSNALEK AO BOSNALEK AO Bosnia and Herzegovina

Information update date: & nbsp30.07.2015

Illustrated instructions

Instructions

Enterofuryl® (Enterofuryl®)