Nifuroxazide - instructions for use, dose, side effects, contraindications

Capsule body composition: dye quinoline yellow - 0.7500%; dye sunset sunset yellow - 0.0059%; titanium dioxide - 2.0000%; gelatin - up to 100%. Composition of cap capsule: dye quinoline yellow - 0.7500%; dye sunset sunset yellow - 0.0059%; titanium dioxide - 2.0000%; gelatin - up to 100%.

1 capsule 200 mg:

Active substance: nifuroxazide - 200.00 mg.

Excipients: sucrose - 70.00 mg; cellulose microcrystalline - 41,50 mg; corn starch - 35,00 mg; magnesium stearate - 3.50 mg.

Description:

Dosage of 100 mg: hard gelatin capsules No. 2. Body and lid yellow, opaque.

Dosage 200 mg: hard gelatin capsules number 0. Body and lid yellow, opaque.

The contents of the capsules are a mixture of powder and granules of yellow color. The seal is allowed the contents of the capsules in lumps.

Pharmacotherapeutic group:Antimicrobial agent - nitrofuran

ATX: & nbsp

A.07.A.X.03 Nifuroxazide

Pharmacodynamics:

Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks the activity of dehydrogenases and depresses the respiratory chains, the cycle of tricarboxylic acids and a number of other biochemical processes in the microbial cell. Destroys the membrane of a microbial cell, reduces the production of toxins by microorganisms.

Highly active in relation to Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.

Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes.

Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp., Pseudomonas spp.

Nifuroxazide does not disturb the balance of the intestinal microflora. With acute bacterial diarrhea, eubiosis of the intestine is restored. When infected with enterotrophic viruses prevents the development of bacterial superinfection.

Pharmacokinetics:

After oral administration nifuroxazide practically not absorbed from the digestive tract and its antibacterial action exerts exclusively in the lumen of the intestine. Nifuroxazide is excreted by the intestine: 20% unchanged, and the rest of the nifuroxazide is chemically altered.

Indications:- Acute bacterial diarrhea, which occurs without deterioration of the general condition, fever, intoxication.

Contraindications:- Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug;

- fructose intolerance, glucose-galactose malabsorption syndrome or insufficiency of sucrose and isomaltase;

- Pregnancy;

- Children under 3 years old.

Pregnancy and lactation:

In studies on animals, there was no teratogenic effect. However, as a precautionary measure, take nifuroxazide during pregnancy is not recommended.

During the lactation period, it is possible to continue breastfeeding in the case of a short course of treatment with the drug. It is necessary to consult a doctor.

Dosing and Administration:

It is applied inside. Capsule should be swallowed whole, washed down with a small amount of water.

Capsules 100 mg

Children from 3 to 6 years: 200 mg (2 capsules) 3 times a day (interval between doses 8 hours), daily dose - 600 mg.

Children from 6 to 18 years: 200 mg (2 capsules) 3-4 times a day (the interval between doses is 6-8 hours), the daily dose is 600-800 mg.

Adults: 200 mg (2 capsules) 4 times a day (interval between doses 6 hours), daily dose - 800 mg.

Capsules 200 mg

Children from 3 to 6 years: 200 mg (1 capsule) 3 times a day (interval between doses 8 hours), daily dose - 600 mg.

Children from 6 to 18 years: 200 mg (1 capsule) 3-4 times a day (the interval between doses is 6-8 hours), the daily dose is 600-800 mg.

Adults: 200 mg (1 capsule) 4 times a day (interval between doses 6 hours), daily dose - 800 mg.

The duration of the course of treatment is 5-7 days, but not more than 7 days. If there is no improvement within the first 3 days, you should consult a doctor. Use the drug only according to the method of administration and at the doses indicated in instructions. If necessary, please consult with your doctor before using the medication.

Side effects:

Allergic reactions (skin rash, hives, Quincke's edema, anaphylactic shock). If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Symptoms of overdose are not described. Treatment is symptomatic.

Interaction:

It is not recommended simultaneous use with drugs that cause the development of disulfiram-like reactions, with drugs that depress the function of the central nervous system.

If you are taking other medications (including OTC drugs) before using the drug Nifuroxazide consult a doctor.

Special instructions:

When treating diarrhea concomitantly with nifuroxazide therapy, rehydration therapy should be performed.

In the case of bacterial diarrhea with signs of systemic damage (worsening of the general condition, fever, symptoms of intoxication, or infection), you should consult your doctor to decide on the use of antibacterial agents of systemic action.

When symptoms of hypersensitivity (dyspnea, rash, itching) occur, stop taking the drug.

During therapy, alcohol is not allowed.

The maximum daily dose of the drug (800 mg) contains 0.023 XE.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles and mechanisms.

Form release / dosage:

Capsules 100 mg and 200 mg.

Packaging:

By 5, 6, 7 or 10 capsules in a contour mesh package made of a polyvinyl chloride film and aluminum foil printed lacquered.

10, 15, 16, 20, 28, 30, 40, 50 or 100 capsules in cans of polyethylene terephthalate for medicines or polypropylene for medicinal products sealed with high-pressure polyethylene caps with a control of the first opening or with polypropylene caps with the "press "turn" or low-density polyethylene caps with the control of the first opening.

One jar or 1, 2, 3, 4, 5, 6 or 10 contour squares, together with the instructions for use, will be placed in a cardboard box (bundle).

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:3 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-004625

Date of registration:12.01.2018

Expiration Date:12.01.2023

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZON PHARM, LLC Russia

Information update date: & nbsp20.02.2018

Illustrated instructions

Instructions

Nifuroxazide (Nifuroxazide)