Stoppier - instructions for use, dose, side effects, contraindications

Excipients: silicon dioxide colloid (Aerosil hydrophilic 200) 3.0 mg, potato starch 179.0 mg, gelatin 11.0 mg, talc 6.0 mg, magnesium stearate 1.0 mg.

Casing of the tablet: hypromelose 3.0 mg, titanium dioxide 0.252 mg, talc 0.062 mg, polyethylene glycol 20 000 0.201 mg, dye quinoline yellow 0.112 mg.

Description:The tablets covered with a film cover of yellow color, round, biconcave.

Pharmacotherapeutic group:antimicrobial agent - nitrofuran

ATX: & nbsp

A.07.A.X.03 Nifuroxazide

Pharmacodynamics:

Nifuroxazide is a derivative of nitrofuran, has an antibacterial effect against gastrointestinal gram-positive bacteria from the genus Staphylococcus and some gram-negative bacteria from the family Enterobacteriaceae of the genus: Yersinia spp., Escherichia spp., Citobacter spp., Enterobacter spp., Salmonella spp.

Nifuroxazide does not have an antibacterial effect on bacteria of the species

Proteus vulgaris, Klebsiella spp., Proteus mirabilis and Pseudomonas aeruginosa.

He affects the composition of the normal bacterial flora of the digestive tract.

The detailed mechanism of action of the drug is unknown.

Nifuroxazide presumably inhibits the activity of dehydrogenases and the synthesis of proteins in bacterial cells.Does not cause the emergence of drug-resistant strains, nor was there a cross-resistance with other antibacterial drugs. The effectiveness of the action of nifuroxazide does not depend on the pH that exists in the lumen of the intestine, nor on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract, it acts exclusively in the lumen of the intestine.

Pharmacokinetics:

Nifuroxazide is hardly soluble. After oral administration, it is practically not absorbed from the digestive tract and does not have a systemic effect. It is excreted through the intestine.

Indications:

Acute and chronic diarrhea of bacterial origin.

Contraindications:Hypersensitivity to nifuroxazide, derivatives of nitrofuran or any auxiliary substance, children under 7 years.

Pregnancy and lactation:

In pregnancy and during breastfeeding apply only if the intended benefit to the mother exceeds the potential risk to the fetus and the baby.

Dosing and Administration:

Inside. Adults and children older than 7 years: 2 tablets (200 mg) 4 times a day after 6 hours.The tablet should be swallowed whole, squeezed it with a suitable amount of water. Do not chew the tablet, do not crush it.

The course of treatment is 3 days, if after this period the symptoms do not disappear, you should consult your doctor.

Side effects:

Nifuroxazide is well tolerated, side effects are almost not observed. In isolated cases, in the presence of increased individual sensitivity to nifuroxazide, possible abdominal pain, nausea and increased diarrhea, granulocytopenia, skin rash, including pustular; nodular pruritis; hyper-responsiveness reactions (dyspnea, swelling of the face, lips, tongue, skin rash, itching). If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:Until now, there have been no reports of cases of overdose with the use of the drug.

Interaction:During treatment with nifuroxazide, simultaneous intake of other medications for oral administration should be avoided due to the pronounced adsorption properties of nifuroxazide.

Special instructions:

During treatment, it is necessary orally or parenterally, depending on the patient's condition, to compensate for fluid loss.

The use of alcoholic beverages during treatment with nifuroxazide may cause a disulfiram-like reaction.

In case of a hyper-responsiveness reaction (dyspnea, swelling of the face, lips, tongue, skin rash, itching), stop taking the drug immediately.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive and work with other mechanisms.

Form release / dosage:

Tablets, film-coated, 100 mg.

Packaging:

24 tablets per blister from A1 / PCV.

One blister with instructions for use in a cardboard box.

Storage conditions:

In a dry, dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children!

Shelf life:

4 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N009992

Date of registration:03.03.2009

The owner of the registration certificate:GEDEON RICHTER, OJSC GEDEON RICHTER, OJSC Hungary

Manufacturer: & nbsp

GEDEON RICHTER POLAND, Co. Ltd. Poland

Representation: & nbspGEDEON RICHTER OJSC GEDEON RICHTER OJSC Hungary

Information update date: & nbsp30.07.2015

Illustrated instructions

Instructions

Stoppier (Stopdiar)