Fenyuls Zinc - instructions for use, dose, side effects, contraindications

Iron sulfate anhydrous	150.0 mg
Zinc sulfate monohydrate	61.8 mg
Folic acid	1.5 mg
Pyridoxine hydrochloride (vitamin AT₆)	3.0 mg
Cyanocobalamin (vitamin B12)	15.00 μg

Excipients: ethylcellulose, shellac, povidone, dye azorubin [E 122], pellets (starch, sucrose, lactose), isopropanol (q.s.).

Capsule the size "1" is dark red / transparent. Capsule shell: topomace: gelatin, dye crimson (Ponso 4R) [E124], dye azorubin [E122], titanium dioxide, methyl parahydroxybenzoate, propyl parahydroxybenzoate; body: gelatin, methyl parahydroxybenzoate, propyl parahydroxybenzoate.

Description:

Capsules with a dark red lid and a transparent body, size 1, containing white, red, yellow and pink pellets.

Pharmacotherapeutic group:multivitamin agent + minerals

ATX: & nbsp

A.11.A.A.04 Multivitamins and microelements

Pharmacodynamics:

Iron, being a part of numerous cellular structures and participating in the activity of many enzymatic systems (cytochromes, catalases, etc.) plays a very important role in the transport of oxygen and oxidative metabolic processes, and is an important element of the human body, which is especially necessary for the formation of hemoglobin.The iron content in the body is maintained at a constant level due to the regulation of its absorption and loss. The drug is used to eliminate iron deficiency.

Zinc - an important element of the human body, which is mainly contained in red blood cells in the form of zinc-metalloenzyme carbonic anhydrase and, to a lesser extent, in blood plasma in a bound state with α-2-macroglobulin. It is part of more than 70 enzymes that catalyze the key steps in the synthesis of DNA, RNA, proteins. Has a pronounced effect on the processes of growth and maturation of tissues, positively affects the retardation of mental and physical development in children. Stabilizes cell membranes, affects regeneration processes, transmits nerve impulses, enhances the action of insulin. Stimulates hair growth, has an immunomodulating effect on the T-cell link of immunity and increases the factors of nonspecific immune defense. It is a powerful antioxidant. Effective in the treatment of acne and alopecia.

Pyridoxine as coenzyme is involved in the metabolism of amino acids, proteins, the synthesis of neurotransmitters.

Folic acid - B group vitamin is involved in key biological processes, namely: in the synthesis of DNA, RNA and proteins. In pregnancy folic acid prevents the development of neural tube defects in the fetus. Deficiency of folate leads to the development of megaloblastic anemia. With a deficiency of folic acid, abortion, premature birth and mental disability can be observed.

Cyanocobalamin in the form of methyl cobalamin is a cofactor of reactions involving methionine synthase. With a deficit of B₁₂ the formation of thymidylic acid and purine nucleosides, the precursors of DNA synthesis, necessary for normal cell division, decreases. Megaloblastic anemia is a consequence of vitamin B deficiency₁₂.

Pharmacokinetics:

Suction. Iron is absorbed, mainly from the 12-finger and jejunum. Maximum absorption is observed with iron on an empty stomach. Absorption varies greatly and depends on iron stores in the body and physiological needs. In iron deficiency states, its absorption increases. The total amount of assimilated iron in the body increases with increasing dose.The time to reach the maximum concentration in the blood is 1-2 hours. Zinc is absorbed in the small intestine: 40-65% in the duodenum, 15-21% - in the lean and iliac.

Distribution. After absorption, the bulk of iron binds to transferrin and is transported to the bone marrow, where it is captured by erythropoiesis cells for hemoglobin synthesis; the rest is contained in the blood and is deposited in organs in the form of ferritin, hemosiderin or myoglobin.

Excretion. A small amount of iron is excreted from the body through the kidneys after the cyclic destruction of the hemoglobin molecule.

Indications:

- Treatment and prevention of conditions caused by deficiency of iron, zinc and folic acid, including before, during and after pregnancy (during lactation) and in children;

- in the complex treatment of skin diseases (juvenile acne, alopecia areata, atopic dermatitis).

Contraindications:

- Hypersensitivity to any component of the drug;

- stenosis of the esophagus and / or obstructive changes in the digestive tract;

- increased iron content in the body (eg, hemochromatosis, hemosiderosis);

- violation of iron utilization (lead anemia, sideroblastic anemia, thalassemia);

- non-iron deficiency anemia (hemolytic anemia or megaloblastic anemia, anemia caused by vitamin B deficiency ₁₂);

- children under 12 years of age (due to lack of clinical data).

Carefully:

Stomach ulcer and duodenal ulcer, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Dosing and Administration:

Inside. Dosage and duration of therapy depends on the severity of iron deficiency. The daily dose of the drug can be taken once a day. Take during or immediately after a meal; to wash down with water.

Treatment of clinically pronounced iron deficiency of mild and moderate degree (iron deficiency anemia): 2 capsules a day for 3-5 months before the normalization of the hemoglobin level in the blood. After normalizing the hemoglobin level in the blood, the maintenance dose is prescribed at the doctor's recommendation.

Treatment of concomitant deficiency of iron, zinc and folic acid - 2 capsules a day. Pregnant women should take 1-2 capsules a day before the normalization of hemoglobin.Then the therapy should be continued at a dosage of 1 capsule per day, at least until the birth to restore iron stores.

For therapy and prevention of latent iron deficiency, zinc deficiency and folic acid, as part of complex treatment of skin diseases (youthful acne, alopecia areata, atopic dermatitis) patients should take 1 capsule of the drug per day.

Side effects:

Very rarely (greater than or equal to 0.001% and less than 0.01%) gastrointestinal irritation symptoms may occur, such as overflow sensation, epigastric pressure, nausea, constipation or diarrhea, and allergic reactions.

Rarely - a headache, a "metallic" taste in the mouth.

Perhaps the dark staining of the stool, caused by the release of non-sucked iron (a clinical value does not matter).

Overdose:

To date, no cases of drug overdose have been reported.

Interaction:

Do not prescribe concurrently with antacids containing salts of aluminum, magnesium, calcium, since the absorption of iron decreases.

Iron reduces the absorption of tetracycline drugs.

Pyridoxine reduces the therapeutic effect of levodopa.

Zn⁺² reduces the absorption of tetracyclines and copper. Zn⁺² is combined with any vitamin and mineral complexes. Pharmaceutically incompatible with salts of silver, lead, quinine, citral (forms poorly soluble compounds). Thiazide diuretics increase excretion Zn⁺² with urine. High doses of iron, penicillamine and other complexing drugs significantly reduce absorption Zn⁺².

In 1 tablet Feniuls ® Zinc contains approximately 45 mg of elemental iron.

Special instructions:

It is not recommended simultaneous use of other multivitamin and mineral complexes in order to avoid overdose.

It should be taken 1 hour before or 2 hours after consuming milk, dairy products, complexing drugs (bicarbonates, carbonates, oxalates, phosphates, tetracyclines and copper).

With prolonged use of zinc preparations, the probability of occurrence of a deficiency of Cu⁺². When taking more than 3-4 months, it is recommended to prescribe medications for copper.

Do not use ethanol containing beverages.

Form release / dosage:

Capsules of prolonged action.

Packaging:

10 capsules in a contour squeeze box (blister) of PVC / PVDNH; 1, 3 or 6 blisters together with instructions for medical use in a cardboard bundle.

For 30, 60 or 90 capsules in a bottle of high-density polyethylene with a screw cap.

1 bottle together with instructions for medical use in a cardboard pack.

Storage conditions:

In a dry place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the date shown on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-007721/09

Date of registration:01.10.2009

Date of cancellation:2017-08-21

The owner of the registration certificate:Ranbaxy Laboratories LimitedRanbaxy Laboratories Limited India

Manufacturer: & nbsp

RANBAXY LABORATORIES, Ltd. India

Representation: & nbspRABBAYS LABORATORY LIMITEDRABBAYS LABORATORY LIMITED

Information update date: & nbsp21.08.2017

Illustrated instructions

Instructions

FENYULS® Zinc (Fenules® Zinc)