Folic acid - instructions for use, dose, side effects, contraindications

Tablets 1 mg - from light yellow to yellow, flat-cylindrical, with a facet; tablets 5 mg - from yellow to dark yellow color, with biconvex surface, with a risk.

Pharmacotherapeutic group:vitamin

ATX: & nbsp

B.03.B.B Folic acid and its derivatives

B.03.B.B.01 Folic acid

Pharmacodynamics:

Folic acid belongs to the vitamins of the group Viv in the body, it is synthesized by the intestinal microflora. Both endo- and exogenous folic acid is reduced to tetrahydrofolic acid-coenzyme, which is necessary for many metabolic processes. Folic acid participates in the synthesis of amino acids, nucleic acids, pyrimidines, purines, the exchange of choline. In combination with vitamin B12 (cyanocobalamin) stimulates the process of hematopoiesis, partly erythropoiesis. It is necessary for the normal development of other blood cells, including the formation and maturation of megaloblasts. A consequence of a deficiency of folic acid is the inhibition of the megaloblastic transition to the normoblastic phase of hematopoiesis.

Pharmacokinetics:

When used internally, it is absorbed in the duodenum and the proximal part of the large intestine. After 3-6 hours, approximately 98.5% of the received amount of the drug is found in the blood. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). About 87% of folates entering the blood are in red blood cells, 10-13% in the blood serum. About 50% of the introduced folate is excreted from the body by the kidneys, the rest is through the intestine.

Indications:

Prevention and treatment of conditions that are caused or accompanied by a deficiency of folic acid:

- treatment of anemia, developing against the background of a deficiency of folic acid: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation; anemia associated with diseases of the small intestine, sprue and malabsorption syndrome.

Contraindications:

Hypersensitivity to the drug components, pernicious anemia, malignant neoplasms, cyanocobalamin deficiency.

Children up to 3 years.

Pregnancy and lactation:

Possible use of the drug during pregnancy and breastfeeding.

Dosing and Administration:

It is applied inside.

Megaloblastic anemia: for adults and children, the initial dose is up to 1 mg / day. When using large doses, resistance may occur. Supportive treatment: for children from 3 to 4 years - 0.3 mg / day, for children over 4 years and adults - 0.4 mg, for pregnancy and lactation - 0.8 mg / day, but not less than 0.1 mg / day.

With a curative purpose (depending on the severity of vitamin deficiency) adults - up to 5 mg / day for 20-30 days, children - in smaller doses.

For prevention (based on the daily requirement), adults are prescribed 150-200 mcg / day, children under 3 years old - 25-50 mcg / day, 4-6 years - 75 mcg / day, 7-10 years - 100 mcg / day; during pregnancy - 400 mcg / day, during lactation - at 300 mcg / day.

Side effects:

Allergic reactions (skin rash, skin itching, bronchospasm, erythema, hyperthermia); from the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

Interaction:

At simultaneous application with chloramphenicol, neomycin, polymyxins, tetracyclines, absorption of folic acid decreases.

Analgesics (long-term therapy), anticonvulsant drugs (incl. phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

The use of folic acid can reduce the plasma level of phenobarbital, phenytoin or primidon and cause an epileptic fit.

Cases of reduction or changes in absorption may occur with the simultaneous use of colestyramine and folic acid, therefore, folic acid should be taken 1 hour before or 4-6 hours after cholestyramine.

Antacids, sulfonamides (incl. sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead, patients using these drugs should be prescribed calcium folinate).

Special instructions:

With pernicious anemia, the drug alone is not used, but only in conjunction with cyanocobalamin (vitamin B ^). When using large doses of folic acid, as well as therapy for a long period, a decrease in the concentration of vitamin B in p-

Form release / dosage:

Tablets 1 mg and 5 mg.

Packaging:

50 tablets in polymer containers.

Each container is put in a pack of cardboard for consumer containers.

Storage conditions:

List B. In a dry, the dark place at a temperature of 15 ° C to 25 ° C. Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LSR-005216/10

Date of registration:07.06.2010

The owner of the registration certificate:TECHNOLOG, JSC TECHNOLOG, JSC Ukraine

Manufacturer: & nbsp

TECHNOLOG, JSC Ukraine

Representation: & nbspFARMKOMPLEKT, LLCFARMKOMPLEKT, LLCRussia

Information update date: & nbsp25.09.2015

Illustrated instructions

Instructions

Folic acid (Folic acid )