Folic acid - instructions for use, dose, side effects, contraindications

Vitamin B (vitamin B, vitamin B9) can be synthesized by the intestinal microflora. In organism folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the exchange of choline, histidine.

Pharmacokinetics:

Folic acid, prescribed as a drug, is well and fully absorbed in the gastrointestinal tract, mainly in the upper parts of the duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue, at the same time, food folates are poorly absorbed in the malabsorption syndrome). Intensively binds to plasma proteins.

Penetrates through blood-brain and placental barriers and penetrates into breast milk.

The time to reach the maximum concentration in the blood plasma (TCah) is 30-60 minutes.

It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

It is excreted by the kidneys mainly in the form of metabolites; if the taken dose significantly exceeds the daily requirement for folic acid, then it is output in unchanged form.

It is excreted by hemodialysis.

Indications:

Treatment of megaloblastic anemia, caused by a deficiency of folic acid. Prevention and treatment of folic acid deficiency in tropical and non-tropical sprue, malnutrition.

Contraindications:

Hypersensitivity to the components that make up the drug; childhood; In 12-deficiency anemia.

Pregnancy and lactation:

In this dosage, the drug can be recommended during pregnancy.

It is not recommended to use the drug in this dosage during the period of breastfeeding, tk. folic acid penetrates into breast milk.

Dosing and Administration:

The drug is taken orally, after eating 1 mg / day. When using large doses, resistance may occur.

The course of treatment is 20-30 days.

Side effects:Allergic reactions - skin rash, skin itching, bronchospasm, erythema, hyperthermia.

Overdose:

Data on overdose are absent.

Interaction:

Anticonvulsant drugs (incl. phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Folic acid reduces the effectiveness of phenytoin.

Antacids (including preparations of calcium, aluminum and magnesium), colestramine, sulfonamides (incl. sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead, patients using these drugs should be prescribed calcium folinate).

Special instructions:

Folic acid is not used to treat B12-deficient (pernicious), normocytic and aplastic anemia. With pernicious (in 12-deficient) anemia folic acid, improving hematologic indices, masks neurological manifestations. While pernicious anemia is not ruled out, administration of folic acid in doses exceeding 0.1 mg / day is not recommended (except pregnancy and lactation period).

Patients on hemodialysis need increased amounts of folic acid (up to 5 mg / day).

During treatment, antacids should be used 2 hours after taking folic acid, colestramine - 4-6 hours before or 1 hour after taking folic acid. It should be borne in mind that antibiotics can distort (give deliberately low values) the results of a microbiological evaluation of the concentration of folic acid in plasma and erythrocytes.

With the use of folic acid, as well as therapy for a long period, a decrease in the concentration of cyanocobalamin is possible.

Form release / dosage:

Tablets 1 mg.

Packaging:

For 10 tablets in a planar cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

For 50 tablets in a polymer jar complete with lids.

Each jar or 5 contour squares, together with the instruction for use, is placed in a bundle.

60 polymer cans are placed in a group package with application instructions in an amount equal to the number of packages.

Storage conditions:

List B. In a dry, the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:P N003076 / 01

Date of registration:14.08.2008

The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Manufacturer: & nbsp

VALENTA PHARMACEUTICS, JSC Russia

Representation: & nbspVALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Information update date: & nbsp25.09.2015

Illustrated instructions

Instructions

Folic acid (Folic acid )