Folic acid (Folic acid )

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceFolic acidFolic acid
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    • Dosage form: & nbsppills
    Composition:
    folic acid - 0.001 g.
    Excipients: sucrose (sugar) - 0.0213 g, dextrose monohydrate (glucose monohydrate) - 0.0989 g, stearic acid 0.0012 g, talc 0.0015 g.

    Description:: tablets of flat-cylindrical form, with a facet, from pale yellow to yellow. Minor inclusions of yellow color are allowed.
    Pharmacotherapeutic group:vitamin
    ATX: & nbsp

    B.03.B.B   Folic acid and its derivatives

    B.03.B.B.01   Folic acid

    Pharmacodynamics:
    Vitamin B (vitamin B, vitamin B9) can be synthesized by the intestinal microflora. In organism folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the exchange of choline, histidine.

    Pharmacokinetics:
    Folic acid, prescribed as a drug, is well and completely absorbed in the gastrointestinal tract, mainly in the upper parts of the duodenum (even in the presence of malabsorption syndrome in the background of tropical sprue, at the same time, food folates are poorly digested in the malabsorption syndrome) . Intensively binds to plasma proteins.
    Penetrates through the blood-brain barrier, the placenta and into breast milk. The time to reach the maximum concentration (TCmax) is 30-60 min.
    It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).
    It is excreted by the kidneys mainly in the form of metabolites; if the taken dose significantly exceeds the daily requirement for folic acid,then it is displayed unchanged.
    It is excreted by hemodialysis.

    Indications:
    Treatment of folic deficiency anemia.
    Hypo - and avitaminosis of folic acid, incl. with tropical and non-tropical sprue, malnutrition.

    Contraindications:
    Hypersensitivity to the components of the drug, B12-deficient anemia, sugar / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, children under 3 years.

    Carefully:
    Folic deficiency anemia with cyanocobalamin deficiency.

    Dosing and Administration:
    Inside.
    Folic deficiency anemia: for adults and children of any age, the initial dose is 1 mg / day. When using large doses, resistance may occur.
    Supportive treatment: for newborns - 0.1 mg / day, for children under 4 years -
    0.3 mg / day, for children over 4 years and adults - 0.4 mg / day, with pregnancy and lactation -
    0.8 mg / day, but not less than 0.1 mg / day.
    With hypo-and avitaminosis folic acid (depending on the severity of avitaminosis) adults - up to 5 mg / day; children - in smaller doses depending on the age. The course of treatment is 20-30 days.
    With concomitant alcoholism, hemolytic anemia, chronic infectious diseases,after gastrectomy, malabsorption syndrome, liver failure, cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

    Overdose:
    Doses of folic acid up to 4-5 mg are well tolerated. Higher doses can cause disorders from the central nervous system and the gastrointestinal tract.

    Special instructions:
    For the prevention of hypovitaminosis folic acid is the most preferred balanced diet.
    Foods rich in folic acid - green vegetables (salad, spinach), tomatoes, carrots, fresh liver, legumes, beets, eggs, cheese, nuts, cereals.
    Folic acid is not used for treatment - scarce, normocytic and aplastic anemia. With B12 - deficiency anemia folic acid, improving hematologic indices, masks neurological complications. While B12 is not excluded - deficiency anemia, the appointment of folic acid at doses exceeding 0.1 mg / day is not recommended (except pregnancy and lactation period).
    It should be borne in mind that patients on hemodialysis need increased amounts of folic acid.
    During treatment, antacids should be used 2 hours after taking folic acid, colestramine - 4 to 6 hours before or 1 hour after taking folic acid.It should be borne in mind that antibiotics can distort (give deliberately low values) the results of a microbiological evaluation of the concentration of folic acid in plasma and erythrocytes.
    When using large doses of folic acid, as well as with therapy over a long period, a decrease in the concentration of vitamin B12 (cyanocobalamin) is possible. Side effect
    Allergic reactions - skin rash, skin itching, bronchospasm, erythema, hyperthermia. Interaction with other medicinal products
    Anticonvulsant drugs (incl. phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.
    Antacids (including preparations of calcium, aluminum and magnesium), colestramine, sulfonamides (incl. sulfasalazine) reduce the absorption of folic acid.
    Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead, patients using these drugs should be prescribed calcium folinate).
    There is no unambiguous information about zinc preparations: some studies show that folates inhibit the absorption of zinc, others disprove these data.Application in pregnancy and during breastfeeding Given that deficiency of folic acid is especially dangerous in the first weeks of pregnancy, this vitamin is recommended to be taken during the preparation for pregnancy, and during the entire period of carrying the baby 1 mg daily.
    With a therapeutic purpose, the dose can be increased to 5 mg per day.
    High doses of folic acid in the period of preparation for pregnancy and in the first third of it are prescribed also to women who already had cases of the birth of children with folic-dependent developmental anomalies.
    The dose and the degree of risk can not be determined on their own, this should only be done by the attending physician.

    Effect on the ability to drive transp. cf. and fur:
    The use of the drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

    Form release / dosage:Tablets of 1 mg.

    Packaging:
    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.
    50 tablets per can of polymeric material.
    The bank or 5 outline packages together with the instruction for use are placed in a pack of cardboard for consumer containers.

    Storage conditions:
    In a dry, the dark place at a temperature of no higher than 25 ° C.
    Keep out of the reach of children.

    Shelf life:
    3 years. Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001467
    Date of registration:30.01.2012
    The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMARBIOFARM, OJSCMARBIOFARM, OJSC
    Information update date: & nbsp25.09.2015
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