Folic acid - instructions for use, dose, side effects, contraindications

Folic acid is part of the vitamin B group. It is found in fresh vegetables (beans, spinach, tomatoes), as well as in the liver and kidneys of animals. In the human body is formed by the microflora of the intestine. For medical purposes are obtained synthetically. Folic acid It is necessary for the normal formation of blood cells, including the processes of maturation of erythroblasts and the formation of normoblasts. Lack of folic acid inhibits the transition of the megaloblastic phase of erythropoiesis to normoblastic. Together with cyanocobalamin (vitamin B12) stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the exchange of choline.

Pharmacokinetics:

Folic acid is well and fully absorbed in the gastrointestinal tract, mainly in the upper parts of the duodenum.

Intensively binds to plasma proteins. Penetrates through the blood-brain barrier, the placenta and into breast milk. The time to reach the maximum concentration is 60 minutes.

It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

It is excreted by the kidneys mainly in the form of metabolites; if the dose is significantly higher than the daily requirement for folic acid, then it is displayed in an unchanged form.

Indications:

treatment of deficiency of folic acid, including against the background of unbalanced and malnutrition;

prevention of neural tube defects in the fetus in the first trimester of pregnancy; - Treatment and prevention of anemia, against the background of a deficiency of folic acid: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megablastic anemia, post-resection anemia, anemia associated with small bowel disease, sprue and malabsorption syndrome.

Contraindications:

Hypersensitivity to the drug components, pernicious anemia, malignant neoplasms, deficiency of cobalamin.

Carefully:

Dosing and Administration:

Apply inside after eating.

To prevent the development of fetal neural tube defects in the first trimester of pregnancy

1 mg per day.

With a therapeutic purpose: adults 1-2 mg per day. Depending on the condition, the dose may be increased to 5 mg per day.

Side effects:

Allergic reactions (skin rashes, itching, erythema, bronchospasm, hyperthermia); from the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

With prolonged use, it is possible to develop hypovitaminosis B12.

Interaction:

Reduces the effect of phenytoin (requires an increase in its dose).

Analgesics (long-term therapy), anticonvulsant drugs (incl. phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including preparations of calcium, aluminum and magnesium), colestramine, sulfonamines (including sulfasalazine) reduce the absorption of folic acid. Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead of it, patients using these drugs should be prescribed calcium folinate).

With simultaneous application with chloramphenicol, neomycin, polymyxin, tetracycline, absorption of folic acid is reduced.

Special instructions:

For the prevention of hypovitaminosis folic acid most preferred. balanced food.Foods rich in folic acid - lettuce, spinach, tomatoes, carrots, fresh liver, beans, beets, eggs, cheese, nuts, cereals.

Folic acid is not used to treat B12 deficiency (pernicious anemia), normocytic and aplastic anemia, as well as anemia refractory to therapy.

With pernicious (In the 12-deficient anemia) folic acid, improving

hematologic indices, masks neurological complications. While pernicious anemia is not ruled out, administration of folic acid in doses exceeding 0.4 mg / day is not recommended (except for pregnancy and lactation periods).

Patients on hemodialysis need elevated amounts of folic acid.

During treatment, antacids should be used 2 hours after taking folic acid, colestramine - 4-6 hours before or 1 hour after taking folic acid.

Antibiotics can distort (give knowingly underestimated indicators) the results of a microbiological evaluation of the concentration of folic acid in plasma and erythrocytes.

When using large doses of folic acid, as well as therapy for a long period, a decrease in the concentration of vitamin B12 is possible.

Form release / dosage:

Tablets 1 mg.

Packaging:

For 10, 50 tablets in a contour

cell pack of film

polyvinylchloride and foil

aluminum printed varnished.

By 10, 20, 30, 40, 50, or 100 tablets

in polymer cans for medicines

One bank or 1, 2, 3, 4, 5, 6, 8 or 10

contour cell packs together

with instructions for use

placed in a cardboard box

(pack).

Storage conditions:

In a dry place, protected from light and out of reach of children, at a temperature not exceeding

25 ° C.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LS-002261

Date of registration:07.02.2012

The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp25.09.2015

Illustrated instructions

Instructions

Folic acid (Folic acid )