The incidence of side effects is described in accordance with the following gradation: very often (≥ 1/10); often (≥ 1/100, <1/10); infrequently (≥ 1/1000, <1/100); rarely (≥ 1/10000, <1/1000); very rarely (<1/10000).
Allergic reactions: infrequently - urticaria, skin rash, itchy skin; rarely - fever, urticaria, angioedema, anaphylactoid reactions; very rarely - eosinophilia.
From the gastrointestinal tract: often - nausea, vomiting, abdominal pain, diarrhea or constipation, flatulence; infrequently - increased activity of "liver" enzymes (transaminases) and alkaline phosphatase (reversible nature), a taste distortion (usually occurs after cessation of therapy); rarely - dry mouth, stomatitis, candidiasis of the gastrointestinal tract,hepatitis (with or without jaundice), microscopic colitis, discoloration of the tongue to brownish-black and the appearance of benign salivary gland cysts with concurrent use with clarithromycin (phenomena are reversible after discontinuation of therapy); very rarely - liver failure (in patients with a previous severe liver disease).
From the nervous system: often - headache; infrequently - dizziness, paresthesia, drowsiness, insomnia; rarely excitation, reversible confusion, depression; very rarely - aggression, confusion, hallucinations; against a background of severe liver disease - encephalopathy.
From the skin and subcutaneous tissues: infrequently - dermatitis; rarely - photosensitivity (reddening of the skin), alopecia; very rarely - multiforme exudative erythema, Stevens-Johnson syndrome (severe erythema multiforme, characterized by the appearance of spots and blisters on the skin and mucous membranes against a background of high fever and joint pain), toxic epidermal necrolysis; frequency unknown - subacute cutaneous lupus erythematosus.
From the side of the organ of vision: infrequently - visual disturbances, including,reduction of visual fields, reduction of acuity and clarity of visual perception (usually occur after discontinuation of therapy).
From the side of the hearing organ and labyrinthine disturbances: infrequently - impairment of auditory perception, including "ringing in the ears" (usually after the termination of therapy), vertigo.
From the musculoskeletal and connective tissue: infrequently - fractures of the vertebrae, bones of the wrist, head of the femur (see section "Special instructions"); rarely - myalgia (pain in the muscles), arthralgia (joint pain), muscle weakness.
From the respiratory system: rarely - bronchospasm.
From the side of the kidneys and urinary tract: rarely - interstitial nephritis.
From the hematopoiesis: rarely - leukopenia, thrombocytopenia; very rarely - agranulocytosis, pancytopenia.
From the endocrine system: very rarely - gynecomastia.
Other: infrequent - peripheral edema, malaise; rarely - increased sweating, hyponatremia; very rarely - hypomagnesemia, hypocalcemia due to severe hypomagnesemia.
There have been reports of cases of the formation of glandular cysts in the stomach in patients taking drugs that reduce the secretion of the glands of the stomach for a long period of time; cysts benign, pass independently on the background of continuation of therapy.
In case of side effects not listed in this manual, you should immediately contact your doctor.