In rare cases, the following, usually reversible, side reactions may occur:
On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, heartburn, dry mouth, taste disorders, stomatitis, pancreatitis (including fulminant), loss of appetite, fecal color changes, esophageal candidiasis, atrophy of the tongue mucosa,transient increase in the activity of "hepatic" enzymes and bilirubin in plasma; in patients with a previous severe liver disease - hepatitis (including jaundice), a violation of liver function or hepatic encephalopathy.
From the central or peripheral nervous system: headache,
dizziness, aggressiveness, apathy, nervousness, agitation, drowsiness, insomnia, tremor, vertigo, paresthesia, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with previous severe liver disease - encephalopathy.
From the cardiovascular system: angina pectoris, tachycardia, bradycardia,
palpitation, arterial hypertension, vasculitis, peripheral edema.
From the genitourinary system: interstitial nephritis, urinary tract infections, leukocyturia, proteinuria, hematuria, glucosuria, increased serum creatinine concentration, gynecomastia, testicular pain.
From the musculoskeletal system: muscular weakness, myalgia, arthralgia, ossalgia (pain in the bones), muscle cramps.
On the part of the hematopoiesis system: pancytopenia, agranulocytosis, anemia (including hemolytic anemia), neutropenia, thrombocytopenia, leukocytosis, and leukopenia.
From the skin: skin itching, skin rash; in some cases - photosensitivity, multiforme exudative erythema, hair loss, alopecia, petechiae, dry skin, epidermal necrosis, Stevens-Johnson syndrome.
On the part of the respiratory system: cough, nosebleeds.
From the sense organs: ringing in the ears, perversion of taste, unexpressed impairment of sight and hearing.
Allergic reactions: urticaria, angioedema, bronchospasm,
interstitial nephritis, anaphylactic shock, fever.
Laboratory indicators: hypoglycemia, hyponatremia.
Other: pain in the back, visual impairment, peripheral edema, increased sweating, gynecomastia; rarely - the formation of gastric glandular cysts during long-term treatment (consequence of inhibition of the secretion of hydrochloric acid, is benign, reversible), increased sweating, general fatigue, general weakness, weight gain.