In rare cases, the following, usually reversible, side effects may occur:
On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dryness of the oral mucosa, taste disorders, stomatitis, transient increase in the activity of "liver" enzymes in the plasma; in patients with a previous severe liver disease - hepatitis (including jaundice), a violation of liver function.
From the nervous system: in patients with severe concomitant somatic diseases - dizziness, headache, agitation, depression, in patients with a previous severe liver disease - encephalopathy.
From the musculoskeletal system: muscle weakness, myalgia, arthralgia.
On the part of the hematopoiesis system: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
From the skin: skin rash and / or itching, photosensitivity,
multiforme exudative erythema, alopecia.
Allergic reactions: urticaria, angioedema, bronchospasm,
interstitial nephritis and anaphylactic shock.
Other: impaired vision, peripheral edema, increased sweating, fever, gynecomastia; the formation of gastric glandular cysts during long-term treatment (consequence of inhibition of the secretion of hydrochloric acid, is benign, reversible).