Active substanceOmeprazoleOmeprazole
Similar drugsTo uncover
  • Gastrozole®
    capsules inwards 
  • Gastrozole®
    capsules inwards 
    OTISIFARM, OJSC     Russia
  • Zhelezol®
    lyophilizate d / infusion 
  • Losek®
    lyophilizate d / infusion 
    AstraZeneca UK Ltd     United Kingdom
  • Losek® MAPS®
    pills inwards 
    AstraZeneca AB     Sweden
  • Omal
    lyophilizate in / in 
    FARMGID CJSC     Russia
  • Omez®
    lyophilizate d / infusion 
  • Omez
    capsules inwards 
  • Omez® Insta
    powdersuspension inwards 
  • Omeprazole
    capsules inwards 
    OZONE, LLC     Russia
  • Omeprazole
    capsules inwards 
    BIOSINTEZ, PAO     Russia
  • Omeprazole
    capsules inwards 
  • Omeprazole
    capsules inwards 
    VALENTA PHARM, PAO     Russia
  • Omeprazole
    capsules
  • Omeprazole
    capsules inwards 
  • Omeprazole
    capsules inwards 
    LEKFARM, SOOO     Republic of Belarus
  • Omeprazole
    capsules inwards 
    AVVA RUS, OJSC     Russia
  • Omeprazole
    capsules inwards 
    SYNTHESIS, OJSC     Russia
  • Omeprazole
    lyophilizate d / infusion 
    Life Sainses OHCF     Russia
  • Omeprazole
    lyophilizate d / infusion 
    ALVILS, LTD.     Russia
  • Omeprazole Zentiva
    capsules inwards 
    Zentiva c.s.     Czech Republic
  • Omeprazole Stada
    capsules inwards 
    NIZHFARM, JSC     Russia
  • Omeprazole-OBL
    capsules inwards 
  • Omeprazole-Acrychin®
    capsules inwards 
    AKRIKHIN HFK, JSC     Russia
  • Omeprazol-Richter
    capsules inwards 
  • Omeprazole-C3
    capsules inwards 
    NORTH STAR, CJSC     Russia
  • Omeprazole-Teva
    capsules inwards 
  • Omizak ®
    capsules inwards 
  • Omitox
    capsules
  • Ortanol®
    lyophilizate d / infusion 
    Sandoz d.     Slovenia
  • Ortanol®
    capsules inwards 
    Sandoz d.     Slovenia
  • Pleom-20
    capsules inwards 
  • Pomez
    capsules inwards 
  • Romesque®
    capsules inwards 
  • Ulcozol®
    capsules inwards 
    VALEANT, LLC     Russia
  • Ultop®
    capsules inwards 
  • Ultop®
    lyophilizate d / infusion 
  • Ultop®
    capsules inwards 
  • Helicid®
    lyophilizate d / infusion 
    Zentiva c.s.     Czech Republic
  • Cisagast
    capsules inwards 
    PRO.MED.CS Prague as.     Czech Republic
  • Dosage form: & nbspenteric-coated capsules
    Composition:

    Each capsule contains pellet omeprazole - 235.00 mg in terms of 20 mg of omeprazole. Pellet composition: Active substance: omeprazole - 8.50 g; Excipients: mannitol - 17.00 g; sucrose - 27.33 g; sodium hydrophosphate (sodium phosphate disubstituted) - 1.27 g; sodium lauryl sulfate - 0.34 g; lactose - 3.40 g; calcium carbonate - 3.40 g; Sheath: hypromellose (hydroxypropylmethylcellulose) - 8.75 g; methacrylic acid and ethyl acrylate copolymer (methacrylic acid copolymer L30D) - 25.00 g; propylene glycol 0.81 g; diethyl phthalate - 2.50 g; cetyl alcohol - 0.75 g; sodium hydroxide (sodium hydroxide) - 0.15 g; polysorbate-80 (tween-80) - 0.30 g; Povidone (polyvinylpyrrolidone) 0.26 g; titanium dioxide - 0.18 g; talc - 0.06 g.

    Capsule composition: titanium dioxide (E 171) 2%, dye quinoline yellow (E 104) 0.75%, dye yellow sunset sunset (E 110) 0.0059, gelatin to 100%.

    Description:

    Hard gelatin capsules number 2. Capsule caps are opaque yellow, the body is opaque white. The contents of the capsules are white or almost white pellets.

    Pharmacotherapeutic group:Proton pump inhibitor.
    ATX: & nbsp

    A.02.B.C.01   Omeprazole

    Pharmacodynamics:

    Omeprazole inhibits the enzyme H+/TO+-ATP-asu ("proton pump") in the parietal cells of the stomach and thereby blocks the final stage of the synthesis of hydrochloric acid.This leads to a decrease in the level of basal and stimulated secretion, regardless of the nature of the stimulus. After a single intake of the drug, omeprazole acts within the first hour and lasts for 24 hours, the maximum effect is achieved after 2 hours. In patients with duodenal ulcer, taking 20 mg of omeprazole maintains an intragastric pH

    - 3.0 for 17 hours. After discontinuation of the drug secretory activity is completely restored after 3-5 days.

    Pharmacokinetics:

    Omeprazole is rapidly absorbed from the gastrointestinal tract, the maximum concentration in the plasma is reached after 0.5-1 hour. Bioavailability is 30 - 40%. The connection with plasma proteins is about 90%. Omeprazole almost completely metabolized in the liver. The half-life is 0.5-1 hour. It is excreted mainly by the kidneys in the form of metabolites. In chronic renal failure, excretion decreases in proportion to a decrease in creatinine clearance. In elderly patients excretion decreases, bioavailability increases. With hepatic failure, bioavailability is 100%, half-life is 3 hours.

    Indications:

    - Peptic ulcer of the stomach and duodenum;

    - Reflux esophagitis;

    - Erosive and ulcerative lesions of the stomach and duodenum associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), stress ulcers.

    - Erosive-ulcerative lesions of the stomach and duodenum, associated with Helicobacter pylori (as part of complex therapy);

    - Zollinger-Ellison syndrome.

    Contraindications:

    Hypersensitivity to the drug, a child's age, pregnancy, lactation.


    Pregnancy and lactation:contraindicated
    Dosing and Administration:

    Inside, squeezed with a small amount of water (the contents of the capsule can not be chewed).

    Peptic ulcer of duodenal ulcer in the phase of exacerbation - 1 capsule (20 mg) per day for 2 to 4 weeks (in resistant cases, up to 2 capsules per day).

    Stomach ulcer in the phase of exacerbation and erosive-ulcerative esophagitis - 1 to 2 capsules per day for 4-8 weeks.

    Erosive-ulcerative lesions of the gastrointestinal tract caused by the intake of NSAIDs

    - 1 capsule per day for 4-8 weeks.

    Eradication Helicobacter pylori - 1 capsule 2 times a day for 7 days in combination with antibacterial agents.

    Anti-relapse treatment of peptic ulcer of stomach and duodenum - 1 capsule per day.

    Antiretroviral treatment of reflux-esophagitis - 1 capsule per day for a long time (up to 6 months).

    Zollinger-Ellison Syndrome - the dose is selected individually depending on the initial level of gastric secretion, usually starting at 60 mg per day. If necessary, increase the dose to 80 - 120 mg per day, in this case, it is divided into 2 divided doses.

    Side effects:

    In rare cases, the following, usually reversible, side effects may occur:

    On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dryness of the oral mucosa, taste disorders, stomatitis, transient increase in the activity of "liver" enzymes in the plasma; in patients with a previous severe liver disease - hepatitis (including jaundice), a violation of liver function.

    From the nervous system: in patients with severe concomitant somatic diseases - dizziness, headache, agitation, depression, in patients with a previous severe liver disease - encephalopathy.

    From the musculoskeletal system: muscle weakness, myalgia, arthralgia.

    On the part of the hematopoiesis system: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

    From the skin: skin rash and / or itching, photosensitivity,

    multiforme exudative erythema, alopecia.

    Allergic reactions: urticaria, angioedema, bronchospasm,

    interstitial nephritis and anaphylactic shock.

    Other: impaired vision, peripheral edema, increased sweating, fever, gynecomastia; the formation of gastric glandular cysts during long-term treatment (consequence of inhibition of the secretion of hydrochloric acid, is benign, reversible).

    Overdose:

    Symptoms of overdose are visual impairment, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia.

    There is no specific antidote. Treatment is symptomatic. Hemodialysis is not effective enough.

    Interaction:

    Long-term use of omeprazole 20 mg once daily in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not change their plasma concentration.

    No interaction with concomitant antacids was noted.

    Changes the bioavailability of any drug, the absorption of which depends on the pH value (for example, iron salts).

    Special instructions:

    Before the start of therapy, it is necessary to exclude the presence of malignant process (especially with gastric ulcer), because treatment, masking the symptoms, can delay the establishment of the correct diagnosis.

    Admission simultaneously with food does not affect its effectiveness.

    If you have difficulty swallowing the whole capsule, you can swallow its contents after opening or dissolving the capsule, and you can mix the contents of the capsule with a slightly acidified liquid (juice, yogurt) and use the resulting suspension for 30 minutes.

    In patients with severe hepatic insufficiency, the daily dose should not exceed 20 mg.


    Effect on the ability to drive transp. cf. and fur:

    In case of adverse reactions from the nervous system, patients are advised to refrain from controlling the car and other mechanisms, as well as to be cautious when engaging in activities that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    Capsules enteric in 20 mg.


    Packaging:

    10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

    By 10, 20, 30, 40, 50 or 100 capsules into a polymer container for medicines. One container or 1, 2, 3, 4, 5, 6, 8 or 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    Storage conditions:

    In a dry, protected from light place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years. Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N003727 / 01
    Date of registration:26.06.2009
    The owner of the registration certificate:OZONE, LLC OZONE, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspOZONE LLC OZONE LLC Russia
    Information update date: & nbsp26.09.2011
    Illustrated instructions
      Instructions
      Up