Classification of unwanted adverse reactions according to the frequency of development: often - 1-10%, not often-0.1-1%, rarely-0.01 -0.1%.
From the digestive system: often - diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence; not often - a transient increase in the activity of "liver" enzymes; rarely - taste disorders, dryness of the oral mucosa, stomatitis, lack of appetite, in patients with a previous severe liver disease - hepatitis (including jaundice), liver dysfunction, candidiasis of the gastrointestinal tract, the formation of gastric glandular cysts during long-term treatment (the consequence of inhibiting the secretion of hydrochloric acid, is benign, reversible).
From the central and peripheral nervous system: often - headache; not often - dizziness, paresthesia, drowsiness, insomnia; rarely - reversible confusion, agitation, aggressiveness, depression and hallucinations (mainly in patients with severe concomitant somatic diseases), in patients with a previous severe liver disease - encephalopathy.
From the musculoskeletal system: rarely - muscle weakness, myalgia, arthralgia.
From the side - bodies hematopoiesis: rarely - leukopenia, thrombocytopenia;
agranulocytosis, pancytopenia.
From the skin: not often - skin rash and / or itching, rarely - photosensitization, multiforme exudative erythema, Stevens-Johnson syndrome, alopecia, toxic epidermal necrolysis.
Allergic reactions: not often - hives, rarely - angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.
From the genitourinary system: rarely - hematuria, proteinuria, urinary tract infection.
From the endocrine system: rarely - gynecomastia.
Other: not often - malaise, rarely - visual impairment, peripheral edema, increased sweating, hyponatremia.