In rare cases, the following usually reversible, side reactions may occur:
From the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, pain in the abdomen, irritable bowel syndrome, heartburn, dry mouth, taste disorders, stomatitis, pancreatitis (including fulminant), loss of appetite, color change in feces, candidiasis of the esophagus, atrophy of the tongue mucosa, transient increase in the activity of "liver" enzymes and bilirubin in plasma; in patients with a previous severe liver disease - hepatitis (including jaundice), a violation of liver function or hepatic encephalopathy.
From the nervous system: headache, dizziness, aggression, apathy,
nervousness, agitation, drowsiness, insomnia, tremor, vertigo, paresthesia, depression, hallucinations,confusion of consciousness; in patients with severe concomitant somatic diseases, patients with previous severe liver disease - encephalopathy.
From the cardiovascular system: stenocardia, tachycardia, aetiology, palpitations, increased blood pressure, vasculitis, peripheral edema. From the genitourinary system: interstitial nephritis, urinary tract infections, microscopic pyuria, proteinuria, hematuria, glucosuria, increased serum creatinine concentration, gynecomastia, testicular pain.
From the musculoskeletal system: muscle weakness, myalgia, arthralgia, ossalgy (pain in the bones), muscle cramp.
On the part of the hematopoiesis system: pancytopenia, agranulocytosis, anemia (including
hemolytic anemia), neutropenia, thrombocytopenia, leukocytosis, and leukopenia.
From the skin: petechia, itchy skin, skin rash; in some cases, photosensitivity, multiforme exudative erythema, hair loss, alopecia, petechiae, dry skin, epidermal toxic necrolysis, Stevens-Johnson syndrome.
On the part of the respiratory system: sore throat, cough, copious nosebleed.
From the sense organs: ringing in the ears, unexplained disturbances of sight and hearing.
Allergic reactions: urticaria, angioedema, bronchospasm, interstitial nephritis, anaphylactic shock, fever.
Laboratory indicators: hypoglycemia, hyponatremia.
Other: pain in the back, increased sweating; rarely - the formation of gastric glandular cysts during long-term treatment (the consequence of inhibiting the secretion of hydrochloric acid, is benign, reversible), general fatigue, general weakness, weight gain, fever.