On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disorders, stomatitis, transient increase in the activity of "liver" enzymes in the plasma; in patients with a previous severe liver disease - hepatitis (including jaundice), a violation of liver function.
From the nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesia, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with previous severe liver disease - encephalopathy.
From the musculoskeletal system: muscle weakness, myalgia, arthralgia.
On the part of the hematopoiesis system: leukopenia, thrombocytopenia; in selected
cases - agranulocytosis, pancytopenia.
From the skin: itching, skin rash; in some cases -
photosensitization, multiforme exudative erythema, alopecia.
Allergic reactions: urticaria, angioedema, bronchospasm,
interstitial nephritis, anaphylactic shock, fever.
Other: impaired vision, peripheral edema, increased sweating,
gynecomastia; rarely - the formation of gastric glandular cysts during long-term treatment (the consequence of inhibition of the secretion of hydrochloric acid, is benign, reversible).
If Ultop is used for a short period of time, the side effect is rarely seen and is of a weak and transient nature. Most often, side effects are noted at the beginning of treatment. During prolonged treatment, the incidence of side effects decreases. Side effects of severe severity are very rare. If they develop, treatment should be interrupted. The incidence of side effects in patients older than 65 years is the same as in younger patients.