Glycerol (Glycerin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGlycerolGlycerol
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    • Dosage form: & nbsprectal suppositories
    Composition:

    Composition per 1 suppository:

    Active substance:

    Glycerol * (in terms of 100% glycerol content) Excipients:

    1.24 g

    2.11 g

    Macrogol 400 (polyethylene oxide 400)

    0.12 g

    0.21 g

    Stearic acid

    0.12 g

    0.205 g

    Sodium carbonate decahydrate

    0.060 g

    0.103 g

    * - the substance content can be from 1.41 g to 1.48 g (for a dosage of 1.24 g) and from 2.40 g to 2.51 g (for a dosage of 2.11 g), depending on the actual content of glycerol in substance.

    Description:Suppositories torpedo-shaped, translucent, almost colorless with a weak yellowish tinge, with an oily smooth surface, with a weak characteristic odor.
    Pharmacotherapeutic group:Laxative
    ATX: & nbsp

    A.06.A.X.01   Glycerol

    Pharmacodynamics:

    Laxative. When used in the form of rectal suppositories, it softens and lubricates hardened fecal masses, facilitates their passage through the large intestine, irritates the intestinal mucosa, reflexively stimulates intestinal motility, initiates the process of defecation, facilitates the passage and excretion of stool.

    Pharmacokinetics:

    It is actively metabolized in the liver.It is excreted through the kidneys, 7-14% are unchanged.

    Indications:

    Symptomatic treatment of constipation of various etiologies (when the use of oral medications is impossible).

    Prevention of constipation in patients who can not strain during defecation: painful thrombosed hemorrhoids, anal fissures or perianal abscess, anorectal stenosis, after a myocardial infarction.
    Contraindications:

    Hypersensitivity to glycerol or any of the components of the drug. Irritable bowel syndrome, intestinal obstruction, appendicitis, bleeding, diarrhea, hemorrhoids in the acute stage, fissures of the anus, inflammatory diseases and rectal tumors, undiagnosed abdominal pain, hemorrhagic rectocolitis, children under 5 years.

    Carefully:Renal failure.
    Pregnancy and lactation:

    In pregnancy, use is contraindicated because of the possible reflex stimulation of the uterus.

    It is not known whether glycerin is excreted into breast milk, so this medication is used only if, in the opinion of the doctor, the expected benefit to the mother exceeds the potential risk to the fetus.

    Dosing and Administration:

    Rectally.

    Enter the drug into the rectum and leave there for at least 5 minutes. Usually, defecation occurs 5-10 minutes after the administration of the drug. The remains of the suppository are removed from the intestine with feces.
    Children from 5 to 12 years are prescribed 1 suppository, containing 1.24 g of glycerin, once a day. Children over 12 years of age and adults are prescribed 1 suppository, containing 2.11 grams of glycerin, once a day. If necessary, increase the dose to 2 suppositories per day.

    Side effects:

    Allergic reactions, local reactions (itching, burning in the anus), the appearance of spasmodic pain in the intestine.

    With prolonged use, irritation of the rectum, weakening of the physiological process of defecation are possible.

    If side effects develop, consult a doctor.

    Overdose:

    Symptom of overdose is frequent loose stools. In case of an overdose cancel the drug.

    Interaction:

    No data.

    Special instructions:

    Before and after using suppositories, you should thoroughly wash your hands. Systematic reception is not recommended. Treatment is discontinued after restoration of normal intestinal peristalsis.It is not recommended to use suppositories for longer than 1 week.

    Do not lubricate the suppository with mineral liquid or solid oils.

    Effect on the ability to drive transp. cf. and fur:Not installed.
    Form release / dosage:

    Suppositories rectal 1,24 g or 2,11 g.

    Packaging:

    For 5 suppositories in a contiguous cell pack of a polymer film of PVC / PE or a combination of aluminum foil and PE.

    Two contoured cells with five suppositories are placed together with the instruction for medical use of the drug in a pack of cardboard.

    Storage conditions:

    At a temperature of no higher than 25 ° C. Keep out of the reach of children.

    Shelf life:

    2 years. Do not use after the expiration date stated on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-004412
    Date of registration:15.08.2017
    Expiration Date:15.08.2022
    The owner of the registration certificate:YUZHFARM, LLC YUZHFARM, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp06.09.2017
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