Included in the formulation
АТХ:M.01.A.X Other non-steroidal anti-inflammatory drugs
Pharmacodynamics:Combined drug.
Glucosamine
Stimulates the development of matrix cartilage tissue, promotes regeneration processes, has a moderate anti-inflammatory effect.
Chondroitin sulfate
It is the main component of proteoglycans, which together with collagen fibers constitute the matrix of cartilage. It acts as a chondroprotector, suppresses the activity of enzymes that promote the degradation of the cartilaginous surface of the joint, activates metabolism in the subchondral bone,stimulates the production of proteoglycans by chondrocytes and the regeneration of cartilaginous tissue. Has analgesic and anti-inflammatory effect, inhibits the secretion of prostaglandin E2 and leukotriene B4, reduces the excretion of inflammatory mediators in the synovial fluid.
Prevents the collapse of connective tissue, promotes the restoration of articular surfaces, improves the production of intraarticular fluid, which improves mobility in the joint and reduces the intensity of pain.
Pharmacokinetics:Glucosamine
After oral administration, it is absorbed in the gastrointestinal tract. It is subjected to primary metabolism in the liver. Bioavailability is 25%. Up to 30% of the amount of the drug taken is accumulated in bone and muscle tissue.
The half-life is 68 hours. Elimination with feces.
Chondroitin sulfate
After oral administration, up to 13% is absorbed in the gastrointestinal tract. The maximum concentration in the blood plasma is achieved in 3-4 hours. After 4-5 hours, it accumulates in the synovial fluid.
The half-life is 68 hours. Elimination with feces.
Indications:
It is used to treat degenerative-dystrophic diseases of the joints and spine with osteochondrosis and osteoarthritis I-III degree.
XIII.M15-M19.M15 Polyarthrosis
XIII.M40-M43.M42 Osteocondritis of the spine
Contraindications:
Age to 15 years, severe renal failure, phenylketonuria, pregnancy and lactation, individual intolerance.
Carefully:
Bronchial asthma, diabetes, hemophilia.
Pregnancy and lactation:
Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside, 1 capsule 3-4 times a day for 3 weeks, then 1 capsule 2 times a day until 3-6 months.
The highest daily dose: 4 capsules.
The highest single dose: 1 capsule.
Side effects:Glucosamine
Central and peripheral nervous system: headache, dizziness, insomnia, drowsiness.
The cardiovascular system: tachycardia, peripheral edema.
Digestive system: flatulence, epigastric pain, constipation or diarrhea.
Allergic reactions.
Chondroitin sulfate
Allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Increases the absorption of tetracyclines.
Reduces the effects of semisynthetic penicillins.
Chondroitin sulfate enhances the effect of anticoagulants.
Special instructions:
In the absence of the effect of treatment within 4 weeks, it is recommended to cancel the drug and clarify the diagnosis.