ARTRA® (ARTRA®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGlucosamine + chondroitin sulfateGlucosamine + chondroitin sulfate
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    • Dosage form: & nbsp
    film coated tablets
    Composition:

    One film-coated tablet contains

    Active active ingredients:

    Glucosamine hydrochloride 500 mg

    Chondroitin sodium sulfate 500 mg

    Excipients: calcium phosphate disubstituted - 230 mg, microcrystalline cellulose - 185 mg, croscarmellose sodium - 80 mg, stearic acid - 70 mg, magnesium stearate - 10 mg.

    Sheath:

    Hydroxypropyl methylcellulose 35 mg, titanium dioxide (E171) 8.2 mg, triacetin 6.8 mg.

    Description:Biconvex tablets are oval in shape, covered with a white to white film cover with a yellowish tinge, interspersed, engraved with "ARTRA" on one side of the tablet, with a specific odor.
    Pharmacotherapeutic group:Regeneration of tissue stimulant
    ATX: & nbsp

    M.01.A.X   Other non-steroidal anti-inflammatory drugs

    Pharmacodynamics:

    Stimulates the regeneration of cartilaginous tissue. Glucosamine and chondroitin sodium sulfate participate in the biosynthesis of connective tissue, helping to prevent cartilage destruction processes and stimulating tissue regeneration. The introduction of exogenous glucosamine enhances the production of the cartilaginous matrix and provides non-specific protection, including from NSAIDs and glucocorticosteroids (GCS). The drug has a moderate anti-inflammatory effect. / p>

    Chondroitin sodium sulfate, whether absorbed in an intact form or as separate components, serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of proteoglycans and collagen type II, and also protects the cartilage matrix from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals; maintains the viscosity of the synovial fluid, stimulates mechanisms of cartilage repair and suppresses the activity of those enzymes (elastase, hyaluronidase), which split the cartilage.In the treatment of osteoarthritis, it alleviates the symptoms of the disease and reduces the need for NSAIDs.

    Pharmacokinetics:

    Bioavailability of glucosamine with oral administration is 25% (the effect of "first passage" through the liver). Distributed in tissues: the highest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in bone and muscle tissue.

    Excreted mainly with urine in an unchanged form; partially with feces. T1 / 2 - 68 hours Bioavailability of chondroitin sulfate about 13%.

    Indications:Osteoarthritis of peripheral joints and spine.
    Contraindications:Hypersensitivity, pronounced impaired renal function.
    Carefully:Bleeding or a tendency to bleeding, bronchial asthma, diabetes mellitus.
    Pregnancy and lactation:It is not recommended to take during pregnancy and lactation.
    Dosing and Administration:Inside. Adults and children over 15 years of age take 1 tablet 2 times a day for the first three weeks; 1 tablet 1 time per day for the following weeks and months. A stable curative effect is achieved when taking the drug for at least 6 months.
    Side effects:Glucosamine: slight abnormalities of the function of the digestive tract (pain in epigastrium, flatulence, diarrhea, constipation), dizziness, skin allergic reactions are possible. Chondroitin: an allergic reaction.
    Overdose:Symptoms: cases of overdose are unknown. Treatment: gastric lavage, symptomatic therapy.
    Interaction:

    It is possible to increase the effect of anticoagulants and antiaggregants.

    Arthra ® increases the absorption of tetracyclines, reduces the effect of semisynthetic penicillins. The drug is compatible with glucocorticoid drugs.

    Effect on the ability to drive transp. cf. and fur:No data.
    Form release / dosage:Film coated tablets.
    Packaging:For 30, 60, 100 or 120 tablets coated with a film shell in a white bottle of high-density polyethylene with a screw cap made of the same material and a safety valve made of foil. The label is attached to the bottle, the bottle is tightened with a polyethylene film and, together with the instruction for use, is placed in a cardboard box.
    Storage conditions:At a temperature of 10 - 30 ° C, in a dry place. Keep out of the reach of children.
    Shelf life:5 years. Do not use after expiry date.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N014829 / 01
    Date of registration:20.12.2007
    Expiration Date:Unlimited
    The owner of the registration certificate:Unipharm, Inc.Unipharm, Inc. USA
    Manufacturer: & nbsp
    Representation: & nbspUNIFARM, Inc. UNIFARM, Inc. USA
    Information update date: & nbsp13.09.2017
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