Kondrorova - instructions for use, doses, side effects, contraindications

Capsule shell composition: purified water 13.536 mg, gelatin 81.024 mg, sodium lauryl sulfate 0.096 mg, povidone 0.096 mg, bronopolum 0.096 mg, titanium dioxide dye 1,056 mg, diamond blue dye 0.088832 mg, quinoline yellow color 0.00768 mg.

* - content in terms of dry matter.

Description:Hard gelatin capsules of light blue color of size "0", containing white or almost white powder.

Pharmacotherapeutic group:Reparation of tissue stimulant

ATX: & nbsp

M.01.A.X Other non-steroidal anti-inflammatory drugs

Pharmacodynamics:

Glucosamine sulfate and chondroitin sulfate participate in the biosynthesis of connective tissue and, as a result, can help prevent cartilage destruction processes and stimulate tissue regeneration.

Pharmacodynamics

Glucosamine sulfate

Glucosamine sulfate is one of the components of the synthesis of hyaluronic acid, which is necessary for the formation of proteoglycans of the structural matrix of joints. It has also been established that glucosamine sulfate protects articular cartilage from the damaging effects of some non-steroidal anti-inflammatory drugs (NSAIDs). Sulfate ion is necessary for the synthesis of glycosaminoglycans, which are esters of sulfuric acid. The ingestion of exogenous glucosamine stimulates the production of a cartilaginous matrix and provides its nonspecific protection. Glucosamine has a certain anti-inflammatory effect.

Xondroitin sulfate

Chondroitin sulfate, whether absorbed in an intact form or in the form of short fragments, serves as an additional substrate for the formation of a healthy cartilage matrix. Chondroitin sulfate (and its derivatives) stimulates the formation of proteoglycans and collagen type II, and also protects the cartilage matrix from enzymatic cleavage (by suppressing the activity of hyaluronidase) and the damaging effect of free radicals. Chondroitin sulfate maintains the viscosity of the synovial fluid, stimulates mechanisms of cartilage repair. Chondroitin sulfate in the treatment of osteoarthritis relieves the symptoms of this disease and reduces the need for NSAIDs.

Pharmacokinetics:

Glucosamine

Absorption

In humans, the bioavailability of glucosamine for oral administration is 25%.

Distribution

After absorption of the oral dose, radiolabeled glucosamine initially found in the components of the plasma and later penetrates into the tissues. The highest concentrations were found in the liver, kidneys and articular cartilage. About 30% of the dose is persistently persistent in the tissues of bones and muscles.

Elimination

The fraction of glucosamine that is not metabolized or does not bind to plasma proteins is excreted mainly in the urine. Most of the drug found in the stool after ingestion is an unabsorbed fraction.The final half-life of the drug bound to plasma proteins is 68 h.

Chondroitin sulfate

Absorption

When chondroitin sulfate is taken orally once in a dose of 0.8 g (or twice a day at a dose of 0.4 g) the concentration of chondroitin sulfate in plasma rises sharply over a period of 24 hours. Absolute bioavailability is 12%.

Metabolism

Chondroitin sulfate is metabolized by desulfurization (after introduction of low-molecular chondroitin sulfate).

Elimination

Chondroitin sulfate is excreted by urine. The half-life is 310 min.

Indications:Osteoarthrosis of peripheral joints and joints of the spine.

Contraindications:

The preparation KONDRONOV® is contraindicated:

- patients with hypersensitivity to the ingredients of this drug;

- pregnant and lactating women;

for children.

Carefully:

Diabetes mellitus, bronchial asthma, a tendency to bleeding, thrombophlebitis.

Dosing and Administration:

Orally. Adults take 2 capsules 2-3 times a day. After 60 days of therapy, the dose should be gradually reduced, depending on the needs of the individual patient.

The course of treatment: 2-3 months (duration of treatment is determined by the doctor).Repeated treatment is possible only after consulting a doctor.

Side effects:

The most common side effects include mild gastrointestinal disorders (epigastric pain, flatulence, diarrhea, constipation), dizziness, skin allergic reactions, headache, leg pain and peripheral edema, drowsiness, insomnia and tachycardia.

Allergic reactions, exacerbation of bronchial asthma are possible.

Overdose:

Cases of an overdose of KONDRONOV® are unknown. In the event of overdose recommended gastric lavage and symptomatic therapy.

Extremely high doses of glucosamine (many times higher than the recommended daily dose) can cause diarrhea or nausea, the appearance of hemorrhagic rashes.

Interaction:It is possible to increase the effect of anticoagulants and antiaggregants. KONDRONOVA increases the absorption of tetracyclines, reduces the effect of semisynthetic penicillins. The drug is compatible with glucocorticoid drugs.

Special instructions:With seafood intolerance, the likelihood of developing allergic reactions increases.

Form release / dosage:

Capsules, 250 mg + 200 mg.

Packaging:

10 capsules per blister of PVC / al.

For 3 blisters together with instructions for medical use in a cardboard box.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 30 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:П N013982 / 01

Date of registration:21.01.2008 / 28.10.2014

Expiration Date:Unlimited

The owner of the registration certificate:Panacea Biotech Co., Ltd.Panacea Biotech Co., Ltd. India

Manufacturer: & nbsp

PANACEA BIOTEC, Ltd. India

Representation: & nbspKORAL-MED, CJSCKORAL-MED, CJSC

Information update date: & nbsp03.02.2018

Illustrated instructions

Instructions

KONDRONOVO® (Kondronova®)