Potassium chloride (Potassium chloride)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substancePotassium chloridePotassium chloride
Similar drugsTo uncover
  • Potassium-normin
    pills inwards 
    Ai Si En Polfa Rzeszow, AO     Poland
  • Potassium chloride
    concentrate d / infusion 
    GROTEKS, LLC     Russia
  • Potassium chloride
    concentrate d / infusion 
    ATOLL, LLC     Russia
  • Potassium chloride
    concentrate inwards d / infusion 
    SLAVYANSKAYA APTEKA, LLC     Russia
  • Potassium chloride
    concentrate d / infusion 
    MICROGEN FGUP Scientific and Production Association     Russia
  • Potassium chloride
    concentrate d / infusion 
    BIOSINTEZ, PAO     Russia
  • Potassium chloride
    solution in / in 
    Armavir Biofactory, FKP     Russia
  • Potassium chloride
    concentrate d / infusion 
    MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC     Russia
  • Potassium chloride
    concentrate d / infusion 
    ESKOM NPK, OAO     Russia
  • Potassium chloride
    concentrate d / infusion 
    NOVOSIBHIMFARM, OJSC     Russia
  • Potassium chloride
    concentrate d / infusion 
    RUSSIAN CARDIOLOGICAL NPK FGU ROSMEDTEKHNOLOGIY - EXPERIMENTAL PRODUCTION OF MEDICAL AND BIOLOGICAL PREPARATIONS     Russia
  • Potassium chloride B. Brown
    concentrate d / infusion 
    B. Brown Mehlungen AG     Germany
  • Potassium chloride buffalo
    concentrate d / infusion 
    UPDATE OF PFC, CJSC     Russia
    • Dosage form: & nbspConcentrate for solution for infusion and oral administration
    Composition:

    Per 1 ml:

    Active substance: potassium chloride - 40 mg.

    Excipients: dextrose monohydrate (glucose) (in terms of anhydrous) - 334 mg, 0.1 M hydrochloric acid solution to pH 3.0 - 4.0; water for injection up to 1 ml.

    Description:Transparent colorless or slightly yellowish liquid.
    Pharmacotherapeutic group:Potassium preparation
    ATX: & nbsp

    B.05.X.A   Electrolyte solutions

    B.05.X.A.01   Potassium chloride

    Pharmacodynamics:

    The preparation of potassium replenishes the deficiency of potassium and chloride ions. Has a negative and chrono- and batmotropic effect, in high doses - negative foreign and dromotropic, as well as moderate diuretic effect. In small doses, the potassium drug dilates the coronary vessels, in large - narrows. Participates in the process of carrying out nerve impulses. With intravenous administration, adrenaline is increased by the adrenal glands.

    Pharmacokinetics:

    The ions of potassium and chlorine are included in the pool of body ions.

    Indications:Hypokalemia of various genesis; arrhythmias due to hypokalemia.
    Contraindications:

    With intravenous administration: hyperkalemia, hypersensitivity to drug components, complete atrioventricular blockade, chronic adrenal insufficiency, concomitant therapy with potassium-sparing diuretics, metabolic disorders (acidosis, hypovolemia with hyponatremia).

    Ingestion: hereditary lactose intolerance, impaired absorption of glucose-galactose, deficiency of lactase.

    Carefully:

    With violations of antrioventricular conduction; concurrent use of angiotensin-converting enzyme inhibitors.

    Ingestion: with diseases of the gastrointestinal tract (bleeding from the gastrointestinal tract, ulcers and perforations of ulcers of the gastrointestinal tract).
    Pregnancy and lactation:

    Use during pregnancy is only possible according to the doctor's prescription, if the intended benefit to the mother exceeds the potential risk to the fetus or baby.

    During the lactation period, it is necessary to resolve the issue of stopping breastfeeding.

    If possible, during pregnancy and lactation, it is necessary to prescribe potassium preparations for oral administration.

    Dosing and Administration:

    The drug is taken or injected intravenously drip.

    If possible, it is necessary to prescribe potassium preparations for oral administration, especially in children.

    The drug is prescribed by mouth for 1 g no more than 7 times a day with a decrease in the daily dose as the therapeutic effect develops. A single dose of the drug before ingestion should be dissolved in 1/2 a glass of water or fruit juice and take after eating.

    At gipokaliemii with disturbances of a warm rhythm - on 1-1,5 g 4-5 times a day; after restoring the heart rhythm, the dose is reduced.

    With glycosidic intoxication - 2-3 g / day, in severe cases up to 5 g.

    To arrest seizures of paroxysmal tachycardia on the first day of 8-12 g, followed by a decrease to 3-6 g.

    With severe intoxication, requiring rapid elimination of pathological phenomena, as well as with persistent vomiting potassium chloride is administered intravenously. Potassium chloride solution 40 mg / ml is diluted 10 times with water for injection, thereby obtaining an isotonic solution. The solution is injected intravenously at a rate of 20-30 cap / min. At the same time, no more than 100 ml of solution is injected. If necessary, the infusion can be repeated, but in such a way that the daily dose does not exceed 300-500 ml.

    The solution is administered intravenously drip - up to 2.5 g of potassium chloride in 500 ml of 0.9% isotonic sodium chloride solution or 5% dextrose solution.

    For the prevention and treatment of ectopic arrhythmias in myocardial infarction - a polarizing mixture: potassium chloride solution 2 - 2.5 g in 500 ml of 5% -10% dextrose solution (short acting insulin is added at the rate of 1 unit for 3-4 g of dry dextrose).

    The procedure for working with a polymer ampoule:

    - Take an ampoule and shake it, holding it by the neck.

    - Press the ampoule with your hand, while the drug should not be isolated, and rotate and separate the valve with rotating movements.

    - Through the formed hole, immediately connect the syringe with the ampoule.

    - Turn the ampoule over and slowly put the contents into the syringe.

    - Put the needle on the syringe.

    Side effects:

    The frequency of adverse events is presented by the World Health Organization (WHO) classification: often 1-10%; infrequently - 0.1-1%; rarely - 0.01-0.1%; very rarely - less than 0.001%, including individual cases.

    From the nervous system: often - paresthesia, rarely - muscle weakness, confusion.

    From the side of the cardiovascular system: often - lowering blood pressure, arrhythmias, very rarely - blockade of the heart, cardiac arrest.

    Other: rarely - hyperkalemia

    From the skin: rarely - a rash, itchy skin.

    Overdose:

    Symptoms: with too rapid intravenous administration - hyperkalemia (muscle hypotension, paresthesia of limbs, slowing of antrioventricular conduction, arrhythmias, cardiac arrest).Early clinical signs of hyperkalemia usually appear at a concentration of potassium ions in the serum of more than 6 meq / l: tapering of the T wave, disappearance of the prong U, segment decline ST, interval lengthening QT, expansion of the complex QRS. More severe symptoms of hyperkalemia - skeletal muscle paralysis and cardiac arrest - develop at a concentration of potassium ions -9-10 meq / liter.

    Treatment: inside or intravenously - a solution of sodium chloride (until the signs of overdose stop); intravenously - 300-500 ml of a 5% solution of dextrose (with 10-20 units of short-acting insulin per 1 liter); if necessary, hemodialysis and peritoneal dialysis.

    Interaction:

    Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerability).

    Strengthens the negative dromo- and batmotropic effect of antiarrhythmic drugs. In the composition of the polarizing mixture (in combination with dextrose and short-acting insulin) it helps to normalize the heart rhythm with myocardial infarction, ectopic arrhythmias and cardiac glycoside overdose.

    Eliminates hypokalemia caused by glucocorticosteroids, mineralocorticosteroids and diuretics.

    Special instructions:

    During the treatment it is necessary to control the content of potassium ions in the blood serum, electrocardiogram (ECG), in the treatment of hypokalemia - control of the acid-base state.

    In rare cases, a paradoxical reaction can occur-an increase in the number of extrasystoles. Ingestion: nausea, vomiting, diarrhea may occur; when taken on an empty stomach, stenosis, ulceration and perforation of the small intestine may develop.

    A diet with a high content of sodium chloride increases the excretion of potassium ions from the body.

    In patients with chronic kidney disease or with any diseases accompanied by a violation of the excretion of potassium from the body, or with too rapid intravenous administration of potassium chloride, the development of hyperkalemia is possible, which develops rapidly and is asymptomatic and can potentially lead to blockade of intracardiac conduction and death.

    It should be borne in mind that the early sign of hyperkalemia leading to death is hypotension, paresthesia of the extremities.

    Effect on the ability to drive transp. cf. and fur:

    During the treatment period, care must be taken when driving vehicles and practicing potentially dangerous speciesactivities that require increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:

    Concentrate for the preparation of solution for infusion and oral administration of 40 mg / ml.

    Packaging:

    By 5 or 10 ml in polymeric ampoules made by technology "blow-fill-seal" "blow-fill-seal".

    For 5 or 10 polymer ampoules, along with the instructions for medical use, put in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-002255
    Date of registration:27.09.2013 / 18.08.2015
    Expiration Date:27.09.2018
    The owner of the registration certificate:SLAVYANSKAYA APTEKA, LLC SLAVYANSKAYA APTEKA, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.11.2017
    Illustrated instructions
      Instructions
      Up