Potassium iodide - instructions for use, dose, side effects, contraindications

Excipients: magnesium hydroxycarbonate (magnesium carbonate basic), sugar milk (lactose), sugar (sucrose), microcrystalline cellulose, magnesium stearate.

Description:Tablets of flat-cylindrical form of white color.

Pharmacotherapeutic group:Thyroxine synthesis regulator - iodine drug

ATX: & nbsp

H.03.C.A Preparations of iodine

Pharmacodynamics:

Upon receipt of iodides at cells of the epithelium of the thyroid follicle, iodine ions under the influence of the iodide-peroxidase enzyme are oxidized to form elemental iodine, which is incorporated into the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodinated, at resulting in the formation of tyronines, the main of which are thyroxine (T₄) and triiodothyronine (T₃). Tyronins form a complex with a protein called thyroglobulin, which is deposited at colloid of the thyroid follicle. Iodine, entering the body in physiological quantities, prevents the development of endemic goiter (associated with a lack of iodine in food); normalizes the size of the thyroid gland in newborns, children and adolescents; and also affects the ratio T₃/T₄, level of thyroid-stimulating hormone.

Indications:

- Prevention of endemic goiter;

- prevention of recurrence of goiter after surgical removal;

- treatment of diffuse euthyroid goiter in newborns, children, adolescents and adult patients of young age.

Contraindications:

- Expressed thyrotoxicosis;

- latent thyrotoxicosis (with doses exceeding 150 μg / day);

- herpetiform dermatitis;

- toxic adenoma, nodular goiter when applied at doses of more than 300 μg / day (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);

- hypersensitivity to iodine.

Potassium iodide should not be taken with hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.

Prescribing the drug should be avoided with radioactive iodine therapy, the presence or suspected of thyroid cancer.

Pregnancy and lactation:

During pregnancy and breastfeeding, the need for iodine increases. Potassium iodide is prescribed according to indications in those cases when the intake of iodine with food is less than 150-300 mcg / day. The drug penetrates well through the placenta and can cause the development of hypothyroidism and goiter in the fetus. Iodine also excreted in breast milk. Therefore, during pregnancy and breastfeeding, the drug should be used only at recommended doses.

Dosing and Administration:

The daily dose of the drug should be taken in one meal after eating, squeezed large amounts of liquid.

When prescribing to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

To perform a dosing regimen of 50 mcg, divisible drug dosage forms should be used.

Prevention of endemic goiter:

Newborns and children: 50 - 100 mcg of iodine per day.

Adolescents and adults: 100 - 200 mcg of iodine per day.

In pregnancy and lactation: 150 - 200 mcg of iodine per day.

Prevention of recurrence of goiter after surgical removal:

100 - 200 mcg of iodine daily.

Treatment of euthyroid goiter:

Newborns, children and adolescents: 100 - 200 mcg of iodine per day.

Adult young patients: 300 - 500 mcg of iodine per day.

Duration of intake of potassium iodide is determined by a physician.

The use of the drug for prophylactic purposes is usually carried out for several months or years.

Children and adolescents usually require a course of treatment of 6 to 12 months.

Side effects:

When using potassium iodide according to the indications in the recommended doses, the occurrence of side effects is unlikely.

Sometimes allergic reactions develop: skin rash, angioedema.

When using the drug in a dose exceeding 150 mcg / day, latent hyperthyroidism can go into a manifest form.

With prolonged use of the drug at a dose exceeding 300 μg / day, it is possible to develop iodine-induced hyperthyroidism (especially in elderly patients with goitre for a long time in the presence of nodular goiter or toxic adenoma).

Overdose:

Symptoms of acute overdose: staining the mucous membranes in brown, reflex vomiting, abdominal pain and diarrhea (possibly, melena). In severe cases, the development of dehydration and shock is possible.

Treatment for acute overdose: gastric lavage, administration of sodium thiosulfate, symptomatic therapy of water-electrolyte balance disturbance, antishock therapy.

Chronic overdose can lead to the development of the phenomenon of "iodism": "metallic" taste in the mouth; edema and inflammation of mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis); acne; dermatitis; swelling of the salivary glands; fever; nervous excitability.

Treatment for chronic overdose: cancellation of the drug.

Interaction:

The effectiveness of treatment with thyreostatics with simultaneous intake of iodine is reduced. Simultaneous reception of antithyroid medications weakens the effect of potassium iodide (mutually).

Perchlorate and potassium thiocyanate inhibit the absorption of iodine by the thyroid gland. Thyrotropic hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.

Simultaneous administration of inhibitors of angiotensin-converting enzyme (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia.

High doses of iodine in combination with potassium-sparing diuretics can lead to hyperkalemia.

Simultaneous administration of iodine therapy in high doses and lithium preparations promotes the development of goiter and hypothyroidism.

Form release / dosage:

Tablets are 100 μg and 200 μg.

Packaging:

For 10 tablets in a planar cell package.

By 20; thirty; 50; 100 tablets in polymer jars.

Each jar or 1, 2, 3, 5, 10 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In a dry, dark place at a temperature of no higher than 20 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-001748/09

Date of registration:10.03.2009

Expiration Date:Unlimited

The owner of the registration certificate:MEDISORB, CJSC MEDISORB, CJSC Russia

Manufacturer: & nbsp

MEDISORB, CJSC Russia

Information update date: & nbsp20.11.2017

Illustrated instructions

Instructions

Potassium iodide (Potassium iodide)