Potassium iodide Renewal - instructions for use, dose, side effects, contraindications

Iodine is a vital microelement. Without iodine, normal functioning of the thyroid gland is impossible, since it is an integral part of thyroxine and triiodothyronine. Thyroid hormones participate in the development of all organs and systems, in the regulation of metabolic processes in the body: protein, fat, carbohydrate and energy, they also regulate the activity of the brain, nervous and cardiovascular system, sex and breast, the growth and development of the child, the formation of its intellectual abilities. Especially dangerous is iodine deficiency for children, adolescents, pregnant and lactating women.

Potassium iodide, being the source of iodine, replenishes its deficiency in the body, prevents the development of iodine deficiency diseases, prevents the development of goiter associated with lack of iodine in food; normalizes the size of the thyroid gland in newborns, children, adolescents and adults.

Pharmacokinetics:

When ingested, the drug is almost completely absorbed into the small intestine. The average volume of distribution for healthy people is approximately 23 liters (38 % body weight). The plasma concentration of iodine is normally between 0.001 and 0.005 μg / ml. It accumulates in the thyroid gland, salivary glands, mammary glands and stomach tissues. Concentration in saliva, gastric juice and breast milk is approximately 30 times higher than in blood plasma. It is excreted by the kidneys, the concentration of iodine in the urine relative to creatinine (μg / g) is an indicator of its intake into the body.

Indications:

- prevention of iodine-deficiency diseases, incl. endemic goiter (especially in pregnant and lactating women);

- prevention of recurrence of goiter after its surgical removal or after completion of treatment of goiter with drugs of thyroid hormones;

- treatment of diffuse euthyroid goiter in newborns, children, adolescents and adult patients of young age.

Contraindications:

- hyperthyroidism;

- subclinical hyperthyroidism when taking doses of iodine more than 150 mcg per day;

- herpetiform dermatitis of Dühring;

- Solitary toxic thyroid adenomas and functional autonomy of the thyroid gland (focal and diffuse), nodal toxic goiter (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);

- hypersensitivity to iodine.

Potassium iodide should not be taken with hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.

Prescribing the drug should be avoided with radioactive iodine therapy, if there is or suspected thyroid cancer.

Since the preparation contains lactose monohydrate, it is not recommended for patients with rare hereditary diseases associated with intolerance to galactose, insufficiency of lactase or glucose-galactose malabsorption.

Pregnancy and lactation:

During pregnancy and breastfeeding, the need for iodine increases,so it is especially important to use the drug Potassium iodide in sufficient doses to ensure adequate intake of iodine in the body. The drug penetrates the placenta and is excreted in breast milk. If a nursing woman takes Potassium iodide, additional prescription of the drug for infants who are breastfeeding is not required.

The use of the drug during pregnancy and during breastfeeding is possible only at recommended doses.

When carrying out therapy, it is necessary to take into account the amount of iodine coming with food.

Dosing and Administration:

When determining the necessary dose of the drug, you need to take into account the regional and individual characteristics of the intake of iodine with food. This is especially important when prescribing the drug to newborns and children under 4 years of age.

Prophylaxis of iodine deficiency disorders:

Newborns and children: 50-100 mcg of iodine per day (1/2 - 1 tablet of the drug Potassium iodide 100 μg);

Adolescents and adults: 100-200 micrograms of iodine per day (1 tablet of the drug Potassium iodide 100 mcg or 1 tablet of the drug Potassium iodide 200 μg);

During pregnancy and during breastfeeding: 100-200 micrograms of iodine per day (1 tablet of the drug Potassium iodide 100 mcg or 1 tablet of the drug Potassium iodide 200 mcg.

Prevention of recurrence of goiter after its surgical removal or after the completion of goiter treatment with drugs of thyroid hormones:

100-200 micrograms of iodine daily (1 tablet of the drug Potassium iodide 100 mcg or 1 tablet of the drug Potassium iodide 200 μg).

Treatment of euthyroid goiter:

Newborns and children: 100-200 micrograms of iodine per day (1 tablet of the drug Potassium iodide 100 mcg or 1 tablet of the drug Potassium iodide 200 μg);

Adolescents and adult patients of a young age: 200 μg of iodine per day (2 tablets of the drug Potassium iodide 100 mcg or 1 tablet of the drug Potassium iodide 200 μg).

The daily dose of the drug should be taken at one time, after eating, with a sufficient amount of liquid. When prescribing to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

The use of the drug for prophylactic purposes is usually carried out for several months or years, and often for the whole life.

To treat goiter in newborns, in most cases, 2-4 weeks is sufficient; children, adolescents and adults usually need 6-12 months or more.The duration of treatment is determined by the doctor.

Side effects:Rarely can there be allergic reactions: skin rash, angioedema.

Overdose:

When prescribing the drug at a dose of more than 150 micrograms per day, patients with thyroid gland foci with functional autonomy may develop iodine-induced hyperthyroidism.

When treated with high doses of iodine (more than 1,000 micrograms per day), iodine-induced goiter and hypothyroidism may develop in some cases.

Chronic overdose can lead to the phenomenon of "iodism": metallic taste in the mouth, swelling and inflammation of mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis), acne, dermatitis, swelling of the salivary glands, fever, irritability.

Treatment: for chronic overdose, it is recommended to stop using the drug. When developing iodine-induced hyperthyroidism, it is recommended to stop the use of the drug and prescribe therapy with antithyroid drugs. In especially severe cases, intensive therapy, plasmapheresis or thyroidectomy should be performed. When developing hypothyroidism, it is recommended to stop the use of the drug and prescribe therapy with iodine-containing thyroid hormones.

Interaction:

The effectiveness of treatment with antithyroid drugs while taking iodine is reduced.

Potassium perchlorate suppresses the absorption of iodine by the thyroid gland.

Taking high doses of iodine and concomitant administration of potassium-sparing diuretics can lead to the development of hyperkalemia.

Simultaneous administration of iodine therapy in high doses with lithium preparations promotes the development of goiter and hypothyroidism.

The absorption of iodine by the thyroid gland and its metabolism are stimulated by a thyroid-stimulating hormone.

Special instructions:

It should be borne in mind that against the background of drug therapy in patients with renal insufficiency, it is possible to develop hyperkalemia.

Before therapy is necessary to exclude the presence of a patient or hyperthyroidism nodular goiter toxic, and the presence of these diseases in history.

In the presence of a predisposition to autoimmune thyroid diseases may formation of antibodies to thyroid peroxidase.

Saturation of the thyroid gland with iodine can prevent the accumulation of radioactive iodine used for therapeutic or diagnostic purposes.In this regard, it is not recommended to take the drug before carrying out activities using radioactive iodine.

Effect on the ability to drive transp. cf. and fur:

Potassium iodide does not affect the ability to drive vehicles and control mechanisms.

Form release / dosage:

Tablets are 100 μg and 200 μg.

Packaging:

For 14 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil.

4, 8 contour cell packs of 14 tablets with instructions for use are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:PL-000588

Date of registration:21.09.2011

The owner of the registration certificate:UPDATE OF PFC, CJSC UPDATE OF PFC, CJSC Russia

Manufacturer: & nbsp

UPDATE, PFC CJSC Russia

Information update date: & nbsp14.01.2013

Illustrated instructions

Instructions

Potassium iodide Renewal (Potassium iodide Reneval)