Iodomarin 100 - instructions for use, dose, side effects, contraindications

Excipientslactose monohydrate 75,119 mg, magnesium carbonate basic 28,250 mg, gelatin 4,000 mg, carboxymethyl starch sodium salt (type A) 4.750 mg, silicon colloidal dioxide 1.750 mg, magnesium stearate 1,000 mg.

Description:Round flat cylindrical tablets of white or almost white color, with a facet and a risk on one side.

Pharmacotherapeutic group:Thyroxine synthesis regulator - iodine drug

ATX: & nbsp

H.03.C.A Preparations of iodine

Pharmacodynamics:

Iodine is a vital microelement that ensures the normal functioning of the thyroid gland, the hormones of which perform many vital functions. They are responsible for the exchange of proteins, fats, carbohydrates and energy in the body, regulate the activity of the brain, nervous and cardiovascular systems, sex and breast, and the growth and development of the child.

Especially dangerous is iodine deficiency for children, adolescents, pregnant and lactating women.

Iodomarin® 100 replenishes iodine deficiency in the body, preventing the development of iodine deficiency disorders and contributing to the normalization of thyroid function, impaired iodine deficiency.

Indications:

- Prevention of endemic goiter (especially in children, adolescents, pregnant and lactating women);

- prevention of recurrence of goiter after its surgical removal or after the end of drug treatment with drugs of thyroid hormones;

- treatment of diffuse euthyroid goiter caused by iodine deficiency in children, adolescents and adults under 40 years.

Contraindications:

- Hyperthyroidism;

- hypersensitivity to iodine;

- toxic adenoma of the thyroid gland, nodular goiter when used at doses of more than 300 μg / day (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);

- herpetiform (senile) dermatitis of Dühring.

The drug should not be used for hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.

The administration of the drug should be avoided with radioactive iodine therapy, the presence or suspected of thyroid cancer.

Pregnancy and lactation:

In pregnancy and lactation, the need for iodine increases, so it is especially important to use in sufficient doses (200 mcg / day) to ensure adequate intake of iodine in the body.

The drug penetrates the placenta and is excreted in breast milk, so the use of the drug in pregnancy and lactation is possible only at recommended doses.

Dosing and Administration:

Prevention of goiter

Newborns and children under 12 years;

½ - 1 tablet of Jodomarina® 100 per day (corresponding to 50-100 μg of iodine).

Children over 12 years and adults:

1-2 tablets of Jodomarina® 100 per day (corresponding to 100-200 μg of iodine).

Pregnancy and lactation period:

2 tablets of Jodomarina® 100 per day (corresponding to 200 micrograms of iodine).

Prophylaxis of goitre recurrence

1-2 tablets of Jodomarina® 100 per day (corresponding to 100-200 μg of iodine).

Treatment of euthyroid goiter

Newborns and children (from 1 year to 18 years of age):

1-2 tablets of Jodomarina® 100 per day (corresponding to 100-200 μg of iodine).

Adults up to 40 years:

3-5 tablets of Iodomarin® 100 per day (corresponding to 300-500 μg of iodine). The drug is taken after a meal, squeezed with enough liquid. Children are advised to pre-dissolve the drug in milk or juice. Prophylactic reception is carried out for several years, in the presence of indications - for life.

For the treatment of goiter in newborns, an average of 2-4 weeks is sufficient, in children, adolescents and adults it usually takes 6-12 months, a long reception is possible.

The duration of treatment is established by the attending physician.

Side effects:

At preventive use at any age, as well as in the treatment of euthyroid goiter in newborns, children and adolescents, side effects are usually not observed. In rare cases, chronic administration of the drug can lead to the development of "yodizma" which can manifest metallic taste in the mouth, swelling and inflammation of the mucous membranes (rhinitis, conjunctivitis, bronchitis), "iodine fever", "an iodine acne."It is extremely rare to develop Quincke's edema, exfoliative dermatitis. When using the drug in a dose exceeding 150 mcg / day, latent hyperthyroidism can go into a manifest form. With prolonged use of the drug at a dose exceeding 300 μg / day, iodine-induced thyrotoxicosis may develop (especially in elderly patients with goitre for a long time if there is nodular or diffuse toxic goiter).

Overdose:

Symptoms: staining the mucous membranes in brown, reflex vomiting (with vomitic components in the food, vomit becomes blue), abdominal pain and diarrhea (possibly melena). In severe cases, the development of dehydration and shock is possible. In rare cases there were stenoses of the esophagus, the appearance of the phenomenon of "iodism" (see Adverse Effect).

Treatment for acute intoxication: rinsing the stomach with a solution of starch, protein or 5% sodium thiosulfate until all traces of iodine are removed. Symptomatic therapy of disturbance of water balance, electrolyte balance, anti-shock therapy.

Treatment for chronic intoxication: cancellation of the drug.

Treatment of iodine-induced hypothyroidism: abolition of the drug, normalization of metabolism with the help of thyroid hormones.

Treatment of iodine-induced thyrotoxicosis: with mild forms of treatment is not required; when the forms are expressed, a thyrostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasmapheresis or thyroidectomy is necessary.

Interaction:

Deficiency of iodine increases, and excess iodine lowers the effectiveness of hyperthyroidism therapy with thyreostatic agents. In this regard, before or during treatment of hyperthyroidism, it is recommended, whenever possible, to avoid any intake of iodine. On the other hand, thyreostatic drugs inhibit the transition of iodine to an organic compound in the thyroid gland and, thus, can cause the formation of goiter.

Simultaneous treatment with high doses of iodine and lithium salts can promote the appearance of goiter and hypothyroidism. High doses of the drug in combination with potassium-sparing diuretics can lead to hyperkalemia.

Effect on the ability to drive transp. cf. and fur:

Iodomarin® 100 does not affect the ability to drive vehicles and control mechanisms.

Form release / dosage:Tablets 100 mcg.

Packaging:

For 50 or 100 tablets in bottles of dark glass.

1 bottle with instructions for use in a cardboard pack.

Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children!

Shelf life:

3 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:П N013943 / 01

Date of registration:18.07.2007 / 12.01.2016

Expiration Date:Unlimited

The owner of the registration certificate:Berlin-Chemie / Menarini Pharma, GmbH Berlin-Chemie / Menarini Pharma, GmbH Germany

Manufacturer: & nbsp

BERLIN-CHEMIE, AG Germany

Representation: & nbspBERLIN-CHEMI / MENARINI PHARMA GmbH BERLIN-CHEMI / MENARINI PHARMA GmbH Germany

Information update date: & nbsp29.11.2017

Illustrated instructions

Instructions

Iodomarin®100 (Iodomarin® 100)