Potassium iodide - instructions for use, dose, side effects, contraindications

Excipients: lactose (milk sugar), magnesium hydroxycarbonate (magnesium carbonate basic), cellulose microcrystalline,) sodium croscarmellose, magnesium stearate, talc, silicon dioxide colloid (aerosil).

Description:

Tablets are white or almost white in color, round, flat-cylindrical, with a facet and a risk.

Pharmacotherapeutic group:Thyroxine synthesis regulator - iodine drug

ATX: & nbsp

H.03.C.A Preparations of iodine

Pharmacodynamics:

Iodine refers to the essential microelements necessary for the normal functioning of the thyroid gland. When iodides enter the epithelial cells of the thyroid follicle, iodine ions under the influence of iodide-peroxidase enzyme are oxidized to form elemental iodine, which is included in the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodinated, resulting in the formation of tyronins, the main of which are thyroxine (T₄) and triiodothyronine (T₃). Tyronins form a complex with protein thyroglobulin, which is deposited in a follicle colloid of the thyroid glands. Iodine, entering the body in physiological quantities, prevents the development of endemic goiter associated with a lack of iodine in food; normalizes the size of the thyroid gland in newborns, children and adolescents; affects the indicators of the ratio T₃/ T₄, the level of thyroid-stimulating hormone.

Pharmacokinetics:

When ingested quickly and completely absorbed in the small intestine and within 2 hours is distributed in the intracellular space.

Accumulates mainly in the thyroid gland (concentration of iodide more than 500 μg/ g tissue), as well as in the salivary and mammary glands, the gastric mucosa. It penetrates well through the placenta.

It is excreted mainly by the kidneys (trace amounts are determined in the urine 10 minutes after the admission, 80% of the dose is excreted within 48 hours, the rest - within 10-20 days), in part - with the secrets of the salivary, bronchial, sweat and other glands.

Indications:

- Prevention of the development of endemic goiter, including during pregnancy;

- prevention of recurrence of goiter after completion of the treatment of goiter with drugs of thyroid hormones or after its surgical removal;

- treatment of diffuse euthyroid goiter in newborns, children, adolescents and adult patients of young age.

Contraindications:

- Expressed thyrotoxicosis;

- latent thyrotoxicosis (when doses exceeding 150 mg / day are used);

- herpetiform dermatitis;

- toxic adenoma, nodular goiter when used in doses more than 300 mcg / day (with the exception of preoperative therapy for the purpose of blocking the thyroid gland);

- hypersensitivity to iodine.

Potassium iodide should not be taken with hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency. Administration of the drug should be avoided with radioactive iodine therapy, presence or suspected carcinoma of the thyroid gland.

Carefully:

FROM caution used in patients with impaired renal function.

Pregnancy and lactation:

During pregnancy and breastfeeding, the need for iodine increases. Potassium iodide is prescribed according to the indications in three cases, when the intake of iodine with food is less than 200 μg / day. The drug penetrates well through the placenta and can cause the development of hypothyroidism and goiter in the fetus.

Iodine is also excreted in breast milk. Therefore, during pregnancy and breastfeeding, the drug should be taken only at recommended doses.

Dosing and Administration:

The daily dose of the drug should be taken in one meal after eating, squeezed large amounts of liquid.

When prescribing to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

If the doctor has not appointed otherwise, then follow the following dosage instructions:

Prevention of endemic goiter:

- Newborns and children: 50-100 micrograms of iodine per day.

- adolescents and adults: 100-200 micrograms of iodine per day.

- during pregnancy and lactation: 150-200 micrograms of iodine per day.

Prevention of recurrence of goiter after completion of treatment with drugs of thyroid hormones or after its surgical removal: 100-200 mcg of iodine daily.

Treatment of euthyroid goiter:

1. newborns, children and adolescents: 100-200 mcg of iodine daily.

2. adult patients of a young age: 300-500 mcg daily. Prophylactic reception of the drug with a preventive purpose is carried out, usually for several months or years, with indications - for life.

Treatment of goiter in newborns is carried out on average for 2-4 weeks, children, adolescents and adults usually need 6-12 months, a long reception is possible.

The duration of treatment is established by the attending physician.

Side effects:

When using potassium iodide according to the indications in the recommended doses, the occurrence of side effects is unlikely.

Sometimes allergic reactions develop: skin rash, angioedema.

When using the drug in a dose exceeding 150 mcg / day, latent hyperthyroidism can go into a manifest form.

With prolonged use of the drug in doses exceeding 300 mg / day, may develop iodine-induced hyperthyroidism (especially elderly patients suffering goiter for a long time, in the presence or toxic nodular goiter adenomas).

Overdose:

Symptoms of acute overdose: staining the mucous membranes in brown, reflex vomiting, abdominal pain and diarrhea (possibly, melena). In severe cases, the development of dehydration and shock is possible.

Treatment for acute overdose: gastric lavage, administration of sodium thiosulfate, symptomatic therapy of water-electrolyte balance disturbance, antishock therapy.

Chronic overdose can lead to the development of the phenomenon of "iodism": "metallic" taste in the mouth; edema and inflammation of mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis); acne; dermatitis; swelling of the salivary glands; fever; nervous excitability.

Treatment for chronic overdose: cancellation of the drug.

Interaction:

Simultaneous reception of antithyroid medications weakens the effect of potassium iodide (mutually).

Perchlorate and potassium thiocyanate inhibit the absorption of iodine by the thyroid gland. Thyrotropic hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.

Simultaneous administration of inhibitors of angiotensin-converting enzyme (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia.

High doses of iodine in combination with potassium-sparing diuretics can lead to hyperkalemia.

Simultaneous administration of iodine therapy in high doses and lithium preparations promotes the development of goiter and hypothyroidism.

Reduces thyroid involvement ¹³¹I and ¹²³I.

Special instructions:

Before the beginning of treatment it is necessary to exclude malignant lesion of the thyroid gland, hyperthyroidism or nodal toxic goiter.

Against the background of drug therapy in patients with impaired renal function, it is possible to develop hyperkalemia (periodic monitoring of the level of potassium in the blood).

Effect on the ability to drive transp. cf. and fur:

Potassium iodide does not affect the ability to drive vehicles and control mechanisms.

Form release / dosage:

Tablets are 100 μg and 200 μg.

Packaging:

For 10 or 25 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil printed lacquered.

According to 1, 2, 3, 4, 5, 10 or 20 contour cell packs of 10 tablets or 2, 4 or 8 contour cell packs of 25 tablets together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.

Shelf life:4 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:P N003537 / 01

Date of registration:31.08.2009

Expiration Date:Unlimited

The owner of the registration certificate:OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Manufacturer: & nbsp

OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC Russia

Information update date: & nbsp19.11.2017

Illustrated instructions

Instructions

Potassium iodide (Potassium iodide)