9 months Potassium iodide - instructions for use, dose, side effects, contraindications

On admission iodides in the follicle epithelial cells of the thyroid gland the iodine ions under the influence of the enzyme peroxidase oxidize iodide to form elemental iodine which is included in the molecule tyrosine Thus one part of tyrosine radicals iodinated thyroglobulin, thereby forming thyronine, the main ones are thyroxine (T4) and triiodogironin (T3). The resulting complex thyronines thyroglobulin and stands out as deposited form thyroid hormone and follicle colloid retained in this state for several days or weeks. With iodine deficiency, this process is disrupted.

Potassium iodide, offsetting iodine deficiency contributes to the restoration of impaired thyroid hormone synthesis, normalizes performance ratio T3 / T4, thereby normalize thyroid function and eliminate iodine deficiency symptoms.

Pharmacokinetics:

Absorption is fast and complete. Plasma concentration - 0.1-0.5 mg / dL. Intensively absorbed by the thyroid gland, which is oxidized to iodine. Substrate provides iodination of tyrosine in the thyroid gland to produce mono- and diiodotyrosine, TK and T4.It also accumulates in salivary and lactating mammary glands, stomach tissues (the content in saliva, milk and gastric juice exceeds the plasma level by 30 times).

It is excreted by the kidneys, partly by the bronchial, salivary and lacrimal glands.

Indications:Preventing the occurrence of iodine deficiency in the body of a woman during pregnancy and during breastfeeding, when the intake of iodine with food is less than 150-300 mcg / day.

Contraindications:

Pronounced and latent hypothyroidism;
herpetiform dermatitis;
hypersensitivity to iodine.

Potassium iodide should not be taken with hypothyroidism, except when the development of the latter is caused by a pronounced iodine deficiency.

Prescribing the drug should be avoided with radioactive iodine therapy, the presence or suspected of thyroid cancer.

Pregnancy and lactation:

During pregnancy and lactation, the need for iodine increases. 9 months Potassium iodide appoint according to the indications in those cases when the intake of iodine with food is less than 150-300 μg / day.

The drug penetrates well through the placenta and when taken in a dose of more than 500 mcg / day can cause the development of hypothyroidism and goiter in the fetus.

Iodine is also excreted in breast milk. When used in the mother during lactation at doses of more than 1000 μg / day, there is a risk of developing hypothyroidism in the infant.

Therefore, during pregnancy and lactation, the drug should be used only in recommended doses.

Dosing and Administration:

Inside, with food, with plenty of liquid.

Apply after consultation with a doctor.

Preventing the occurrence of iodine deficiency in the body of a woman during pregnancy and during breastfeeding: 9 months Potassium iodide appoint a dose of 200 mcg / day (1 tablet), while not recommended for simultaneous reception of other iodine-containing drugs.

The duration of the course is determined by the doctor.

Side effects:

When 9 months of potassium iodide is used, it is unlikely that side effects will occur due to indications in the recommended doses.

Sometimes allergic reactions develop: skin rash, angioedema.

Overdose:

Symptoms of acute overdose: staining the mucous membranes in brown, vomiting, abdominal pain and diarrhea (possible melena). In severe cases, the development of dehydration and shock is possible.

Treatment for acute overdose: gastric lavage, administration of sodium thiosulfate, symptomatic therapy of water-electrolyte balance disturbance, antishock therapy.

Chronic overdose can lead to the development of the phenomenon of "iodism": "metallic" taste in the mouth; edema and inflammation of the mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis); acne; dermatitis; swelling of the salivary glands; fever; nervous excitability.

Treatment for chronic overdose: cancellation of the drug.

Interaction:

Antithyroid drugs and potassium iodide mutually weaken each other's effects.

Potassium perchlorate and potassium thiocyanate suppress the absorption of iodine by the thyroid

gland. Thyrotropic hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.

Simultaneous administration of inhibitors of angiotensin-converting enzyme (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia.

High doses of iodine in combination with potassium-sparing diuretics can lead to hyperkalemia.

Simultaneous administration of iodine therapy in high doses and lithium preparations promotes the development of goiter and hypothyroidism.

Special instructions:

Prolonged intake of potassium iodide in doses exceeding 1000 mcg / day causes a decrease in the absorption of iodine by the thyroid gland and the synthesis of thyroid hormones, which subsequently manifests itself in the form of hypothyroidism and the onset of goiter.

On the background of therapy in patients with renal insufficiency, it is possible to develop hyperkalemia.

Form release / dosage:Tablets 200 mcg.

Packaging:

25 tablets per contour cell packaging made of polyvinyl chloride film and aluminum foil printed lacquered.

For 2 or 4 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-008614/09

Date of registration:28.10.2009 / 26.06.2017

Expiration Date:Unlimited

The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Manufacturer: & nbsp

VALENTA PHARMACEUTICS, JSC Russia

Representation: & nbspVALENTA PHARM, PAO VALENTA PHARM, PAO Russia

Information update date: & nbsp03.05.2018

Illustrated instructions

Instructions

9 months Potassium iodide (9 months Potassium iodide)