Krasgemodez 8000 (Krashaemodes 8000)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePotassium Chloride + Calcium Chloride + Magnesium Chloride + Sodium Hydrocarbonate + Sodium Chloride + Povidone-8 Thousand.Potassium chloride + Calcium chloride + Magnesium chloride + Sodium bicarbonate + Sodium chloride +Povidone-8 thousand.
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    • Dosage form: & nbspsolution for infusions
    Composition:

    Povidone 8000 (low molecular weight polyvinylpyrrolidone medical 8000 ± 2000) - 60.00 g; sodium chloride - 5.5 g; potassium chloride 0.42 g; calcium chloride hexahydrate - 0.5 g; magnesium chloride hexahydrate 0.005 g; sodium bicarbonate 0.23 g; water for injection - up to 1 liter

    Description:Transparent liquid of light yellow or yellow color.
    Pharmacotherapeutic group:Detoxifying agent
    ATX: & nbsp

    B.05.A.A   Blood plasma preparations and plasma-substituting drugs

    Pharmacodynamics:

    The effect of the drug is due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood and quickly remove them from the body. The most fully binds toxins circulating in the blood of patients with dysentery, salmonella, food intoxication.

    With burn disease, the toxins formed in the first 4-5 days of the disease are almost completely inactivated; toxins formed at a later date are much less neutralized.

    Toxins formed in the body of patients with acute radiation sickness do not bind, although it is possible to accelerate their excretion from the body.

    The drug contributes to the elimination of stasis of erythrocytes in capillaries, developing with intoxication of any origin, which leads to an improvement in microcirculation. It enhances kidney blood flow, increases glomerular filtration and increases diuresis.

    The drug is non-toxic, does not have antigenic and pyrogenic properties.The decrease in the molecular weight of the polymer accelerates the excretion of it by the kidneys from the body and improves the detoxification properties of the preparation.

    Pharmacokinetics:Metabolism in the body is not affected. Quickly excreted by the kidneys, within 4 h- 80%, after 12-24 h - completely.
    Indications:

    Shock (posttraumatic, postoperative, burn, hemorrhagic), intoxication (toxic diseases of the gastrointestinal tract, including dysentery, dyspepsia, salmonellosis, burn, radiation and hemolytic disease, peritonitis, intestinal obstruction, thyrotoxicosis, liver disease, sepsis, pneumonia, acute phase of myocardial infarction), toxemia of newborns, gestosis.

    Contraindications:

    Hypersensitivity, intracranial hypertension, hemorrhagic stroke, condition after craniocerebral trauma, chronic heart failure IIb-III st., respiratory insufficiency, severe allergic reactions, thromboembolism, oliguria, anuria, acute nephritis, bronchial asthma, phlebothrombosis.

    Dosing and Administration:

    Intravenously, drip - 40-80 cap / min.

    The dose depends on the age of the patient and the severity of intoxication.

    Single dose for adults - 200-500 ml; for children - 5-10 ml / kg.

    The maximum single dose for infants is 50-70 ml; 2-5 years - 100 ml; 5-10 years -150 ml; 10-15 years - 200 ml.

    The drug is administered once or up to 2 times a day for 1-10 days, depending on the severity of intoxication:

    - with acute gastrointestinal infections, burn and radiation diseases are administered 1-2 times a day;

    - with hemolytic disease and toxemia of newborns - 2-8 times a day (daily or every other day);

    - with large focal myocardial infarction (in the 1st day) - 200 ml once, with complications on the 2nd day - 200 ml.

    Side effects:

    Reduced blood pressure, tachycardia, difficulty breathing (with rapid administration), allergic reactions of varying severity (up to the development of anaphylactic shock).

    Infection at the injection site, thrombosis or phlebitis, spreading from the site of infusion.
    Interaction:

    When combined with diuretic drugs, KrasgoModez 8000 enhances their effect.

    Special instructions:

    With extensive burns combined with the introduction of plasma, albumin, gamma globulin.

    Before the start of the infusion, it is necessary to check the expiration date of the preparation indicated on the bottle label. The drug should be transparent, do not contain suspended matter,Sediment The results of visual inspection are recorded in the medical history.

    During the treatment, it is necessary to monitor blood pressure and the patient's condition. Before the introduction, the preparation is warmed to body temperature. In case of allergic reactions, the drug should be stopped immediately and, without removing the needles from the vein, administer antihistamine (or glucocorticosteroid) drugs.

    Form release / dosage:

    Solution for infusion.

    Packaging:

    For 200 ml, 400 ml in bottles are glass. Bottle with instructions for use in a pack of cardboard.

    For hospital:

    - 24 bottles of 200 ml, 12 bottles of 400 ml without packs with 5 instructions for use in a box of corrugated cardboard.

    - 1 bottle with instructions for use (from 1 to 24 bottles of 200 ml, from 1 to 12 bottles of 400 ml with an equal number of instructions for use) without a bundle in a box of corrugated cardboard.

    Storage conditions:

    At a temperature of 0 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:4 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002279 / 01
    Date of registration:13.10.2008 / 11.09.2012
    Expiration Date:Unlimited
    The owner of the registration certificate:KRASFARMA, JSC KRASFARMA, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp22.01.2018
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