Isoniazid
From the nervous system:
headache, dizziness, rarely excessive fatigue or weakness, irritability, euphoria, insomnia, paresthesia, numbness of limbs, peripheral neuropathy, optic neuritis, polyneuritis, psychosis, mood change, depression. Seizures can occur in patients with epilepsy.
From the cardiovascular system:
palpitation, angina, increased blood pressure.
From the digestive system:
nausea, vomiting, gastralgia, toxic hepatitis.
Allergic reactions:
skin rash, itching, hyperthermia, arthralgia.
Other:
very rarely - gynecomastia, menorrhagia, a tendency to bleeding and hemorrhage.
Rifampicin
From the digestive system:
nausea, vomiting, diarrhea, decreased appetite, erosive gastritis,pseudomembranous enterocolitis; increased activity of "hepatic" transaminases in the blood serum, hyperbilirubinemia, hepatitis.
Allergic reactions:
urticaria, eosinophilia, angioedema, bronchospasm, arthralgia, fever.
From the nervous system:
headache, decreased visual acuity, ataxia, disorientation.
From the urinary system:
nephronecrosis, interstitial nephritis.
Other:
leukopenia, dysmenorrhea, induction of porphyria, myasthenia gravis, hyperuricemia, exacerbation of gout.
With an irregular reception or with the resumption of treatment after the break, an influenza-like syndrome (fever, chills, headache, dizziness, myalgia), skin reactions, hemolytic anemia, thrombocytopenic purpura, acute renal failure are possible.
Pyrazinamide
From the digestive system:
nausea, vomiting, diarrhea, "metallic" taste in the mouth, impaired liver function (decreased appetite, liver tenderness, hepatomegaly, jaundice, yellow atrophy of the liver); exacerbation of peptic ulcer.
From the central nervous system:
dizziness, headache, sleep disturbances, increased excitability,depression; in some cases - hallucinations, convulsions, confusion.
On the part of the organs of hematopoiesis and the system of hemostasis:
thrombocytopenia, sideroblastic anemia, erythrocyte vacuolization, porphyria, hypercoagulation, splenomegaly.
From the musculoskeletal system:
arthralgia, myalgia.
From the urinary system:
dysuria, interstitial nephritis.
Allergic reactions:
skin rash, hives.
Other:
hyperthermia, acne, hyperuricemia, exacerbation of gout, photosensitivity,
increased serum iron concentration.
Ethambutol
From the nervous system and sensory organs:
weakness, headache, dizziness, impaired consciousness, disorientation, hallucinations, depression, peripheral neuritis (paresthesia in the limbs, numbness, paresis, pruritus), optic neuritis (decreased visual acuity, violation of color perception, mainly green and red, color blindness, scotoma).
From the digestive system:
decreased appetite, nausea, vomiting, gastralgia, impaired liver function - increased activity of "liver" transaminases.
Allergic reactions:
dermatitis, skin rash, itching, arthralgia, fever, anaphylaxis.
Other:
hyperuricemia, exacerbation of gout.
Pyridoxine
Rare: skin rash, itching of the skin.
Treatment of patients with a multicomponent drug reduces the patient's medical burden by 3 times, which contributes to the improvement of drug tolerance.