Libaccil® is administered iv and i / m. The mode of administration depends on the severity of the infection and the chosen dose.
In adults, for the treatment of infections of moderate severity, I / in or / m 1.5 g every 6 hours. In severe infections - 3 g every 6 hours. The maximum daily dose of sulbactam should not exceed 4 g, which corresponds to a daily dose of Libaccyl® 12 g.
As a rule, the treatment is continued for another 48 hours after the normalization of body temperature and the disappearance of other symptoms of infection. The duration of the course of therapy is from 5 to 14 days, however, in more severe cases it can be increased or additionally assigned ampicillin.
Have children from 1 month to 12 years (or a body weight of up to 40 kg) Libaccil® with a mild and moderate infection is administered at a dose of 150 mg / kg per day, which is divided into 3-4 injections. For the treatment of severe infections, the dose is increased to 300 mg / kg per day. Usually, the course of treatment with Libacilum® should not exceed 14 days.
In preterm infants and children of the first week of life, The daily dose of Libaccil® is 75 mg / kg, divided by 2 IV.
Children aged from 7 days to 28 days, appoint a dose of 150 mg / kg / day, divided into 3 intravenous injections.
For perioperative prevention surgical infections Libaccil® is administered iv in a dose of 1.5-3 g together with premedication or anesthesia; if necessary, additionally administered at the same dose every 6-8 hours within 24 hours after the operation.
Have patients with renal insufficiency because of the slow elimination of the components of the drug, it is required to increase the intervals between the administrations, as shown in the table:
| Creatinine clearance, ml / min / 1.73 m2 | T1/2, h | Recommended mode of administration |
| ≥30 | 1 | 1,5-3,0 g every 6-8 h |
| 15-29 | 5 | 1,5-3,0 g every 12 h |
| 5-14 | 9 | 1,5-3,0 g every 24 h |
In children with kidney failure (creatinine clearance less than 30 ml / min / 1.73 m2) are administered in usual single doses (50-75 mg / kg), increasing the intervals between administrations, as indicated for adults.
Rules for solution preparation and introduction
To prepare a solution for intravenous administration, sterile water for injection, 0.5% procaine solution, 0.5% or 2% lidocaine solutions is used as the solvent. To the vial containing 750 mg of the preparation, 2.0 ml, 1.5 g - 4 ml of solvent are added.
For intravenous spraying: 10-15 ml of water for injection, 0.9% of sodium chloride solution are added to a vial containing 750 mg or 1.5 mg of Libaccil®. Enter iv slowly for 3-5 minutes.
For IV injection: 1.5-3.0 g of the drug are dissolved in 15 ml of water for injection, then the resulting solution is added to 150-250 ml of a 0.9% sodium chloride solution or 5% solution of dextrose and injected at a rate of 60 -80 drops in min.