The drug is administered intramuscularly or intravenously (drip, jet).
Standard dosing regimen
The following are the total doses of ampicillin and sulbactam (in a 2: 1 ratio).
Adults: from 1500 mg to 12000 mg per day. With a mild infection, 1500-3000 mg / day in 2 injections; at an average current - 3000-6000 mg / day in 3-4 injections; in severe cases - 12000 mg / day in 3-4 injections.
For children: 150 mg / kg body weight per day (corresponding to 100 mg / kg / day ampicillin and 50 mg / kg / day sulbactam) every 6-8 hours in accordance with the usual practice of ampicillin.
Newborns under 1 week of age (especially premature infants): 75 mg / kg of body weight per day with an interval of 12 hours.
Elderly patients: usual doses for adults, without adjustments for age.
Use in patients with impaired renal function (creatinine clearance ≤30 ml / min): In such a patient, Ammiside should be administered less frequently in accordance with the usual practice of using ampicillin, increasing the interval between injections of the drug.
Duration of treatment:
The duration of the course of therapy is 5-14 days, but in more severe cases it can be increased or additionally assigned ampicillin. As always with antibiotic therapy, Ammiside should be administered to the patient for at least 48 hours after the normalization of temperature and the disappearance of other pathological symptoms.
Dosing in special cases:
Uncomplicated gonorrhea single intramuscular injection of 1500 mg of Ammiside. In order to increase the duration of the content of sulbactam and ampicillin in the plasma should be administered simultaneously probenecid at a dose of 1000 mg orally.
Prevention of postoperative infections, depending on the degree of infectious risk, 1500-3000 mg of Ammiside is administered during the initial anesthesia. The dose can be repeated every 6-8 hours; in most surgical interventions, the drug is usually discontinued 24 hours after the operation unless the administration of the drug for therapeutic purposes is shown.
Method of preparation of solutions
For intramuscular injection: the contents of the vial are dissolved as follows:
The contents of the vial 375 mg in 1.0 ml of the solvent (0.5% lidocaine hydrochloride solution) 750 mg in 1.8 ml of the solvent 1500 mg in 3.5 ml of the solvent.
As with other intramuscular injections, Ammiside is injected into a relatively large muscle (gluteal), trial aspiration helps to avoid unintentional insertion into the blood vessel. The drug, diluted with lidocaine, can not be administered intravenously.
For intravenous administration: for the initial dilution the contents of the vial are diluted as follows:
The contents of the vial 375 mg in 1.0 ml of the solvent (water for injection) 750 mg in 1.8 ml solvent, 1500 mg in 3.5 ml of solvent.
Then for intravenous infusion: Cooked with an initial dilution of a solution containing a single dose of the drug is dissolved in 100-200 ml of 0.9% sodium chloride solution or 5-10% glucose solution. Enter with a speed of 60-80 drops per minute.
-for blasting: Cooked with an initial dilution of a solution containing a single dose of the drug is dissolved in 10-20 ml of 0.9% sodium chloride and injected slowly, over 3-5 minutes. Shake before use.