Intravenously (jet and drip), intramuscularly. The mode of administration depends on the severity of the infection and the chosen dose. The following are the total doses of ampicillin and sulbactam (in a 2: 1 ratio).
In adults and children over 12 years of age and weighing more than 40 kg for treatment of infections of an average degree of gravity enter in / m or in / in on 1,5 g every 6 hours.
In severe infections - 3 g every 6 hours.The maximum daily dose of sulbactam should not exceed 4 g, which corresponds to a daily dose of 12 g.
Treatment should be continued for at least another 2-3 days after the disappearance of the clinical symptoms of the disease. Duration of treatment is 5-14 days, but in more severe cases it can be increased or prescribed additionally ampicillin.
With uncomplicated gonorrhea - 1.5 g once.
For the prevention of postoperative infection - 1,5-3 g during anesthesia, then within 24 hours after the operation in the same dose every 6-8 hours.
In children older than 1 month and up to 12 years of age (or weighing less than 40 kg) the drug is administered at a dose of 150 mg / kg per day, which is divided into 3-4 injections. In severe infection, the dose can be increased to 300 mg / kg / day. The duration of the course of therapy should not exceed 14 days.
In preterm infants and children of the first week of life, the daily dose of the drug is 75 mg / kg, which is divided into two injections.
In children from 7 days to 28 days, the drug is prescribed at a dose of 150 mg / kg per day, divided into 3 intravenous infusions.
In patients with impaired renal function, correction of the dosing regimen is performed depending on the values of creatinine clearance (CK).
| Creatinine clearance, ml / min | T 1/2, h | Recommended mode of administration |
| ≥30 | 1 | 1,5-3 g every 6-8 h |
| 15-29 | 5 | 1,5-3 g every 12 h |
| 5-14 | 9 | 1,5-3 g every 24 hours |
In children with kidney failure (CC less than 30 ml / min), the drug is administered in usual single doses (50-75 mg / kg), increasing the intervals between administrations, as indicated in adults.
Preparation of solutions:
To prepare the solution for the / m administration, sterile water for injection, 0.5% procaine solution, 0.5% lidocaine solution is used as the solvent. 4 ml of the solvent are added to the vial containing 1.5 g of the preparation.
To prepare a solution for IV infusion into the bottle containing 1.5 g of the drug, add 12 ml of water for injection, 0.9% solution of sodium chloride. Enter slowly for 3-5 minutes.
To prepare a solution for intravenous drip 1.5-3 g of the drug is dissolved in 15 ml of water for injection, then the resulting solution is added to 150-200 ml of a 0.9% solution of sodium chloride or 5% solution of dextrose and injected at a rate of 60 -80 drops per minute.