Lincomycin - instructions for use, doses, side effects, contraindications

Description:Capsules hard gelatinous № 0, the case and a cover of white color. The contents of the capsules are a granulate containing granules and white powder.

Pharmacotherapeutic group:Antibiotic-Lincosamide

ATX: & nbsp

J.01.F.F Lincosamides

J.01.F.F.02 Lincomycin

Pharmacodynamics:

Antibiotic from the group of lincosamines, produced Streptomyces lincolnensis. In therapeutic doses acts bacteriostatically, at higher concentrations has a bactericidal effect. Suppress protein synthesis of bacteria due to reversible binding to 50S subunit of ribosomes, disrupts the formation of peptide bonds.

To lincomycin are sensitive:

- in vivo: Staphylococcus aureus (penicillin-producing and non-producing strains), Streptococcus pneumoniae;

- in vitro: aerobic Gram-positive cocci (Streptococcus pyogenes, Streptococcus spp. groups viridians), aerobic gram-positive sticks (Corynebacterium diphtheriae), anaerobic gram-positive spore-forming sticks (Propionibacterium acnes), anaerobic gram-positive spore-forming sticks (Clostridium perfringens, Clostridium tetani).

Lincomycin is effective against Staphylococcus spp., resistant to penicillin, tetracyclines, chloramphenicol, streptomycin, cephalosporins (30% Staphylococcus spp., resistant to erythromycin, have cross resistance to lincomycin).

Lincomycin is ineffective against most strains Enterococcus faecalis; does not apply to Neisseria gonorrhoeae, Neisseria miningitidis, Haemophilus influenzae and other gram-negative bacteria, as well as fungi and viruses.The optimum action is in alkaline medium (pH 8.0-8.5).

Resistance to lincomycin develops slowly.

Pharmacokinetics:

Suction: absorption - 30-40% (food intake slows down speed and degree of absorption). Time to reach the maximum concentration in blood plasma - 2-3 hours.

Distribution: well penetrates into the tissues of the lungs, liver, kidneys, through the placental barrier, into breast milk; in high concentrations found in bone tissue and joints. Through the blood-brain barrier lincomycin penetrates slightly, with meningitis - permeability increases.

Metabolism: partially metabolized in the liver.

Excretion: the half-life is normally 5 hours, but this period may be prolonged if the liver and / or kidney function is impaired. It is excreted unchanged in the form of metabolites with bile and kidneys.

Indications:Infectious-inflammatory diseases caused by microorganisms sensitive to lincomycin, lung abscess, pleural empyema, pleurisy, otitis, postoperative purulent complications, wound infection, skin and soft tissue infections (pyoderma, furunculosis, phlegmon, erysipelas), acute and chronic osteomyelitis, purulent arthritis.

Contraindications:

Hypersensitivity to lincomycin and clindamycin, sugarase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (since the preparation contains sucrose), hypersensitivity to other components of the drug, severe hepatic and / or renal insufficiency, pregnancy (except when necessary on "vital" indications), the period of breastfeeding, children's age to 12 years (for this dosage form).

Carefully:

Fungal diseases of the skin, mucous membrane of the oral cavity, vagina, diabetes mellitus (1 capsule of lincomycin includes 29.88 mg of sucrose), moderate hepatic insufficiency.

Pregnancy and lactation:

The use of the drug during pregnancy is only possible if the intended benefit to the mother exceeds the potential risk to the fetus.

For the duration of treatment, breastfeeding should be discontinued.

Dosing and Administration:

Inside, for 1-2 hours before meals or 2-3 hours after meals.

Adults and children over 12 years of age - 500 mg (2 capsules) 2-3 times a day. Duration of treatment, depending on the form and severity of the disease is 7-14 days (with osteomyelitis - 3 weeks or more).

Side effects:

From the digestive system: glossitis, stomatitis, nausea, vomiting, diarrhea, epigastric pain, abdominal pain, transient hyperbilirubinemia, impaired liver function (including increased activity of "liver" transaminases), jaundice, pruritus anus; with prolonged use - candidiasis of the gastrointestinal tract, colitis (including pseudomembranous).

From the hematopoiesis: reversible neutropenia, leukopenia, thrombocytopenic purpura, agranulocytosis, aplastic anemia and pancytopenia.

Allergic reactions: urticaria, angioedema, serum sickness, anaphylactic shock.

From the skin: rash, exfoliative or vesiculobullous dermatitis, erythema multiforme (including Stevens-Johnson syndrome).

From the urinary system: disturbance of kidney function (azotemia, oliguria, proteinuria).

From the genitourinary system: vaginitis.

Other: tinnitus, vertigo.

Overdose:

Symptoms: may increase dose-related side effects.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

Interaction:

Antagonism - with erythromycin, chloramphenicol, ampicillin and other bactericidal antibiotics, synergism with aminoglycosides.Antidiarrhoeal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours). Strengthens the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and stopping breathing.

When used simultaneously with lincomycin, a cytochrome P450 inhibitor, the effect of theophylline may increase. In this case, a decrease in the dose of theophylline is required.

Special instructions:

With prolonged or repeated courses, treatment should be performed under the control of liver function (control of the activity of "liver" transaminases) and kidney function.

The appointment to patients with hepatic insufficiency is permissible only for "vital" indications.

If there are signs of pseudomembranous colitis (diarrhea, leukocytosis, fever, abdominal pain, discharge with mucous masses of blood and mucus) in mild cases, it is enough to cancel the drug and prescribe the appropriate treatment.

The composition of 1 capsule of lincomycin includes 29.88 mg of sucrose, which should be taken into account when treating patients with diabetes mellitus.

Effect on the ability to drive transp. cf. and fur:

Data on the effect of lincomycin on the ability to drive vehicles, mechanisms and to engage in other activities that require concentration and speed of psychomotor reactions are not present.

Form release / dosage:

Capsules 250 mg.

Packaging:

10 capsules are placed in a contour mesh box made of PVC film and aluminum foil. 1 or 2 contour squares, together with instructions for use, are placed in a pack of cardboard.

Storage conditions:

Store in a dry, protected from light place at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002308

Date of registration:04.04.2012

Expiration Date:Unlimited

The owner of the registration certificate:MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC Russia

Manufacturer: & nbsp

MOSHIMFARM PREPARATES them. NA Semashko OJSC Russia

Information update date: & nbsp10.04.2018

Illustrated instructions

Instructions

Lincomycin (Lyncomycin)