Lincomycin - instructions for use, doses, side effects, contraindications

Excipients: sucrose - 20.16 mg, calcium stearate - 1.75 mg, potato starch - sufficient amount to the mass of the contents of the capsule 350 mg; the composition of the capsule is hard gelatin: gelatin - 80,751 mg, glycerol (glycerin) - 0,121 mg, purified water - 13,92 mg, titanium dioxide 1,153 mg, sodium lauryl sulfate - 0.055 mg.

Description:Capsules hard gelatin, white color number 0. Contents of capsules-powder of white color. It is allowed to have capsule-shaped seals in the form of a column or a tablet, which, when pressed lightly with a glass rod, crumble.

Pharmacotherapeutic group:Antibiotic-Lincosamide

ATX: & nbsp

J.01.F.F Lincosamides

J.01.F.F.02 Lincomycin

Pharmacodynamics:

Antibiotic, produced Streptomyces lincolnensis, has a bacteriostatic effect. Suppress protein synthesis of bacteria due to reversible binding to 50Sthe subunit of the ribosomes, disrupts the formation of peptide bonds.

Sensitive in vivo: Staphylococcus aureus (penicillin-producing and non-producing strains), Streptococcus pneumoniae.

Sensitive in vitro: aerobic gram-positive cocci - Streptococcus pyogenes, Streptococcus spp. groups viridans; aerobic Gram-positive sticks - Corynebacterium diphthieriae; anaerobic gram-positive spore-forming sticks - Propionibacterium acnes; anaerobic gram-positive spore-forming sticks - Clostridium tetani, Clostridium perfringens.

Ineffective in most strains Enterococcus faecalis; does not apply to Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae and other gram-negative bacteria, as well as fungi and viruses.

The optimum action is in alkaline medium (pH 8-8.5).Resistance to lincomycin develops slowly. In high doses has a bactericidal effect.

Pharmacokinetics:

Absorption - 30-40% (eating slows down speed and degree of absorption). The time to reach the maximum concentration in blood plasma is 2-3 hours. It penetrates well into the tissues of the lungs, liver, kidneys, through the placental barrier, into the breast milk; in high concentrations found in bone tissue and joints. Across hemato-encephalic barrier (BBB) lincomycin penetrates slightly, with meningitis - permeability increases. Partially metabolized in the liver. Half-life is 5 hours. It is excreted unchanged in the form of metabolites with bile and kidneys.

Indications:Bacterial infections caused by sensitive to lincomycin microorganisms (especially staphylococci and streptococci, especially microorganisms resistant to penicillins, as well as with allergies to penicillins): subacute septic endocarditis, lung abscess, pleural empyema, pleurisy, otitis, osteomyelitis (acute and chronic), purulent arthritis, postoperative purulent complications, wound infection, skin and soft tissue infections (pyoderma, furunculosis, phlegmon, erysipelas).

Contraindications:Hypersensitivity to lincomycin and other components of the drug, pregnancy (with the exception of cases when it is necessary for "vital" indications), severe hepatic and / or renal insufficiency; deficiency of sugar / isomaltase, intolerance to fructose, glucose-galactose malabsorption; children under 12 years (for this dosage form).

Carefully:

Diabetes mellitus, fungal diseases of the skin, mucous membrane of the oral cavity, vagina.

Pregnancy and lactation:

It is not recommended to use the drug during pregnancy and lactation. In the second and third trimester of pregnancy, it is possible to prescribe the drug only for "vital" indications. If it is necessary to use the drug during breastfeeding, it is necessary to resolve the issue of stopping breastfeeding.

Dosing and Administration:

Inside, for 1-2 hours before eating.

For adults and children over 12 years 500 mg 2-3 times a day.

Duration of treatment, depending on the form and severity of the disease is 7-14 days (with osteomyelitis - 3 weeks or more).

With prolonged or repeated courses, treatment should be performed under the control of liver and kidney function.

Side effects:

From the digestive system: glossitis, stomatitis, nausea, vomiting, diarrhea, itching of the anus; jaundice, a violation of the liver (including increased activity of "liver" transaminases); with prolonged use in large doses, it is possible to develop pseudomembranous colitis.

On the part of organs hematopoiesis: neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia, pancytopenia.

Allergic reactions: angioedema, serum sickness, anaphylactic reactions; multiform erythema (in some cases similar to Stevens-Johnson syndrome).

From the skin: rash, hives, exfoliative or vesicle-bulbous dermatitis.

From the genitourinary system: renal dysfunction (azotemia, oliguria, proteinuria), vaginitis.

From the side of the cardiovascular system: stopping breathing and heart (with rapid intravenous injection).

From the sense organs: noise in the ears, vertigo.

If any side effects occur, see a doctor.

Overdose:

Symptoms: increased side effects from the digestive system, with prolonged use of the drug,especially in high doses, it is possible to develop candidal infection and pseudomembranous colitis.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy, poorly removed with hemo- and peritoneal dialysis. With the development of pseudomembranous colitis, it is necessary to cancel therapy with lincomycin.

Interaction:

Antagonism with erythromycin, chloramphenicol, ampicillin and other bactericidal antibiotics, synergism with aminoglycosides.

Antidiarrhoeal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours).

Strengthens the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and stopping breathing.

When used simultaneously with lincomycin, a cytochrome P450 inhibitor, the effect of theophylline may increase and require a reduction in its dose.

Special instructions:

Against the background of long-term treatment, periodic monitoring of the activity of "liver" transaminases and kidney function is necessary. The appointment to patients with hepatic insufficiency is permissible only for "vital" indications.When there are signs of pseudomembranous colitis (diarrhea, leukocytosis, fever, abdominal pain, secretion of blood and mucus in the blood) in mild cases, it is sufficient to discontinue the preparation and assign ion-exchange resinscolestramine), in severe cases, compensation for loss of fluid, electrolytes and protein, vancomycin as a solution for oral administration in a daily dose of 0.5-2 g (for 3-4 doses) for 10 days or bacitracin.

The drug in a daily dose (1.5 g) contains 0.05 XE carbohydrates, which should be taken into account in the treatment of patients with diabetes mellitus.

Effect on the ability to drive transp. cf. and fur:

Does not affect.

Form release / dosage:Capsules 250 mg.

Packaging:

10 capsules per contour cell package. 2 contour mesh packages along with the instruction for use are placed in a pack.

Packaging for hospitals: 150 contour-cell packs with an equal number of instructions for use are placed in a cardboard box.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after the expiration date stated on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-000520

Date of registration:30.06.2010 / 22.06.2015

Expiration Date:Unlimited

The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus

Manufacturer: & nbsp

BELMEDPREPARATY, RUP Republic of Belarus

Information update date: & nbsp10.04.2018

Illustrated instructions

Instructions

Lincomycin (Lincomycin)