Ecolinkom® (Ecolincom)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
Read on
Active substanceLincomycinLincomycin
Similar drugsTo uncover
  • Lincomycin
    capsules inwards 
    ATOLL, LLC     Russia
  • Lincomycin
    capsules inwards 
    MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC     Russia
  • Lincomycin
    capsules inwards 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Lincomycin
    solution w / m in / in 
    BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC     Republic of Belarus
  • Lincomycin
    capsules inwards 
    SYNTHESIS, OJSC     Russia
  • Lincomycin
    solution w / m in / in 
    Company DEKO, LLC     Russia
  • Lincomycin
    solution w / m in / in 
    MICROGEN FGUP Scientific and Production Association     Russia
  • Lincomycin
    capsules inwards 
    NORTH STAR, CJSC     Russia
  • Lincomycin hydrochloride
    solution d / infusion 
    BELMEDPREPARATY, RUP     Republic of Belarus
  • Lincomycin hydrochloride
    solution for injections 
    MOSHIMFARM PREPARATES them. N.А.Semashko, OJSC     Russia
  • Lincomycin hydrochloride-Vial
    solution w / m in / in 
    VIAL, LLC     Russia
  • Ecolinkom®
    capsules inwards 
    AVVA RUS, OJSC     Russia
    • Dosage form: & nbspCapsules.
    Composition:Active substance: linkomycin hydrochloride monohydrate (in terms of linkomycin) - 250 mg; Excipients: lactulose, povidone low molecular weight, talc, magnesium stearate, potato starch.
    Capsule shell composition: gelatin, water, titanium dioxide, dye quinoline yellow, dye sunset yellow.
    Description:Capsules No. 00 with a white casing and a yellow lid. The contents of the capsules are a granular powder of white or almost white color.

    Pharmacotherapeutic group:Antibiotic is lincosamide.
    ATX: & nbsp

    J.01.F.F   Lincosamides

    J.01.F.F.02   Lincomycin

    Pharmacodynamics:The antibiotic produced by Streptomyces lincolniensis has a bacteriostatic effect. Suppress protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds.
    It is active against gram-positive cocci (Staphylococcus spp., Streptococcus spp., Including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
    Effective against Staphylococcus spp., Resistant to penicillin, tetracyclines, chloramphenicol, streptomycin, cephalosporins (30% Staphylococcus spp., Resistant to erythromycin, have cross resistance to lincomycin).
    Does not affect Enterococcus spp (including Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa; is inferior in activity to erythromycin against spore forming anaerobes, Neisseria spp., Corynebacterium spp.
    The optimum action is in alkaline medium (pH 8-8.5). Resistance to lincomycin develops slowly. In high doses has a bactericidal effect.
    Pharmacokinetics:Absorption - 30-40% (eating slows down speed and degree of absorption). The time to reach the maximum concentration is 2-3 hours. It penetrates well into the tissues of the lungs, liver, kidneys, through the placental barrier,into breast milk; in high concentrations found in bone tissue and joints. Through the blood-brain barrier lincomycin penetrates slightly, with meningitis - permeability increases.
    Partially metabolized in the liver. The half-life is 5 hours. It is excreted unchanged in the form of metabolites with bile and kidneys.
    Indications:Infectious-inflammatory diseases caused by sensitive microorganisms (especially staphylococci and streptococci, especially microorganisms resistant to penicillins, as well as allergic to penicillins): sepsis, subacute septic endocarditis, chronic pneumonia, lung abscess, pleural empyema, pleurisy, otitis, osteomyelitis (acute and chronic), purulent arthritis, postoperative purulent complications, wound infection, skin and soft tissue infections (pyoderma, furunculosis, phlegmon, erysipelas).
    Contraindications:Hypersensitivity, pregnancy (except when necessary for "vital" indications), lactation period, severe hepatic and / or renal insufficiency; children's age (up to 3 years).
    Carefully:Fungal diseases of the skin, mucous membrane of the mouth, vagina.
    Dosing and Administration:Inside, 1-2 hours before or 2-3 hours after meals, 2-3 times a day at intervals of 8-12 hours. For adults, the daily dose of -1-1.5 g, single - 0.5 g. For children aged 3 to 14 years, the daily dose - 30-60 mg / kg.
    Duration of treatment, depending on the form and severity of the disease is 7-14 days (with osteomyelitis - 3 weeks or more).
    With prolonged or repeated courses, treatment should be performed under the control of liver and kidney function.
    Side effects:From the digestive system: nausea, vomiting, diarrhea, epigastric pain, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of "liver" transaminases; with long-term use-the candidiasis of the gastrointestinal tract, pseudomembranous enterocolitis. Other fungal infections of the genital tract.
    From the hematopoiesis: reversible leukopenia, thrombocytopenia, neutropenia.
    Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock.
    Overdose:There is no evidence of an overdose of the drug.
    Interaction:Antagonism - with erythromycin, chloramphenicol, ampicillin, and other bactericidal antibiotics, synergism with aminoglycosides.
    Antidiarrhoeal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours).
    Strengthens the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and stopping breathing.
    When used simultaneously with lincomycin, an inhibitor of P450, the serum concentration of theophylline may increase and this will require a reduction in its dose.
    Special instructions:Against the background of long-term treatment, periodic monitoring of the activity of "liver" transaminases and kidney function is necessary.
    The appointment to patients with hepatic insufficiency is permissible only for "vital" indications.
    When there are signs of pseudomembranous enterocolitis (diarrhea, leukocytosis, fever, abdominal pain, discharge with mucous masses of blood and mucus) in mild cases, it is sufficient to discontinue the preparation and prescribe ion-exchange resinscolestramine), in severe cases, compensation for loss of fluid, electrolytes and protein, vancomycin - Inside, in a daily dose of 0.5-2 g (for 3-4 doses) for 10 days or bacitracin.
    Form release / dosage:Capsules 250 mg.
    Packaging:For 20 capsules in cans of polymer or polymer bottles.
    10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.
    Each jar or bottle, 1, 2 contour mesh packages together with instructions for use are placed in a pack of cardboard.
    Storage conditions:List B. In a dry, the dark place at a temperature of no higher than 25 ° C.
    Keep out of the reach of children.
    Shelf life:4 years. Do not use after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-001563/08
    Date of registration:14.03.2008 / 25.04.2012
    Expiration Date:Unlimited
    The owner of the registration certificate:AVVA RUS, OJSC AVVA RUS, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp2016-10-18
    Illustrated instructions
      Instructions
      Up