Intravenously sprayed, drip-drip and drip. Doses and the speed of administration of the drug should be selected individually in accordance with the indications and the patient's condition, the value of blood pressure, heart rate, hematocrit.
Immediately before the use of the drug, except for urgent conditions, a skin test is performed.
Intradermal test is carried out 24 hours before the infusion of the drug. To do this, from a bottle with Rheopolyglucin by puncturing a sterile syringe connected to it with a single-use system, 0.2-0.3 ml of the drug is taken, which is administered intradermally at a dose of 0.05 ml to form a lemon crust on the inside of the forearm, shoulder or other area, available for visual evaluation of the skin test. The doctor evaluates the reaction after 24 hours.
The presence of redness on the spot (diameter more than 1.5 mm), the formation of a papule or the appearance of symptoms of a general reaction in the form of nausea, dizziness or other manifestations through 10-15 minutes after the injection, indicates an increased sensitivity of the patient to the drug and the impossibility of using the drug in this patient. If any reactions are absent, the patient is administered the required amount of the preparation of the series that was used to conduct the intradermal test. The result of the test is recorded in the medical history.
It should be remembered that the skin test does not allow to reveal sensibilization to Reopoliglukin in 100% of patients. Therefore, in the first 5-10 minutes as the intravenous drug in each case, you need to carefully monitor the patient's condition.
In the case of emergency conditions, when applying the drug, it is necessary to conduct a bioassay: after a slow introduction of the first 5 drops of the drug, stopping for 3 minutes, then inject another 30 drops and stop the infusion for 3 minutes. In the absence of a reaction, continue the injection. The results of the bioassay must be recorded in the medical history.
1. When there is a violation of capillary blood flow (various forms of shock) injected intravenously drip or drip-drop, at a dose of 0.5 to 1.5 liters, until the hemodynamic parameters stabilize at the life-supporting level.If necessary, the amount of the drug can be increased to 2 liters.
Children at various forms of shock are introduced at the rate of 5-10 ml / kg, the dose may be increased if necessary to a maximum of 15 ml / kg. It is not recommended to reduce the hematocrit value below 25%.
2. With cardiovascular and plastic operations injected intravenously drastically, immediately before surgery, for 30 to 60 minutes to adults and children in a dose of 10 ml / kg, during surgery, adults - 500 ml, children - 15 ml / kg.
After operation the drug is administered intravenously drip (within 60 minutes) for 5-6 days at the rate of:
adults - 10 ml / kg once,
children up to 2-3 years - 10 ml / kg 1 time per day,
children under 8 years - 7-10 ml / kg 1-2 times a day,
children under 13 years - 5-7 ml / kg 1-2 times a day.
For children older than 14 years, the doses are the same as for adults.
3. In operations with artificial circulation the drug is added to the blood at the rate of 10-20 ml / kg of the patient's body weight to fill the oxygenator pump. The concentration of dextran in the perfusion solution should not exceed 3%. In the postoperative period, the doses of the drug are the same as for a violation of capillary blood flow.
4. With the aim of detoxification injected intravenously drip in a single dose of 500 to 1250 ml (in children 5-10 ml / kg) for 60-90 minutes. If necessary, you can introduce another 500 ml of the drug in the first day (in children the administration of the drug in the first day can be repeated in the same doses). In the following days, the drug is administered drip, adults - in a daily dose of 500 ml, for children - at the rate of 5-10 ml / kg.