Reopoliglyukin-40 (Rheopolyglukin-40)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceDextran [average molecular weight 35,000-45,000]Dextran [average molecular weight 35,000-45,000]
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    • Dosage form: & nbspsolution for infusions
    Composition:

    Dextran 40 000 100.0 g, sodium chloride 9.0 g, water for injection up to 1 liter.

    Theoretical osmolarity 310 mOsm / l

    Description:Transparent, colorless or slightly yellowish viscous liquid.
    Pharmacotherapeutic group:plasma-substituting agent
    ATX: & nbsp

    B.05.A.A   Blood plasma preparations and plasma-substituting drugs

    Pharmacodynamics:

    Reopoliglyukin-40 is a preparation of low molecular weight dextran. It reduces the aggregation of blood elements, facilitates the movement of fluid from tissues into the bloodstream.

    In this regard, the drug increases the suspension properties of blood, reduces its viscosity,contributes to the restoration of blood flow in small capillaries, has a detoxification effect, prevents and reduces the aggregation of blood cells.

    Pharmacokinetics:

    Dextran is excreted from the body through the kidneys (on the first day up to 70%).

    Indications:

    Reopoliglyukin-40 is used for violations of capillary blood flow, for the prevention and treatment of traumatic, surgical and burn shock; violations of arterial and venous circulation, for the treatment and prevention of thrombosis, thrombophlebitis, endarteritis; at operations on heart spent with use of the device of an artificial circulation (for addition to a perfusion liquid); in vascular and plastic surgery to improve local circulation; for detoxification with burns, peritonitis, pancreatitis, and the like.

    Reopoliglyukin-40 is prescribed for diseases of the retina and optic nerve, inflammatory processes of the cornea and the vascular membrane.

    Contraindications:

    The drug is contraindicated in thrombocytopenia, kidney disease (with anuria), heart failure and in cases where large quantities of liquid should not be administered.

    Deficiency of fructose-1,6-diphosphatase, increased individual sensitivity to the drug, pulmonary edema, hyperkalemia.

    Dosing and Administration:

    Reopoliglyukin-40 is administered only intravenously!

    The dose is set individually and depends on the clinical situation and the patient's condition.

    Because of the possibility of developing anaphylactic reactions, the first 10-20 minutes inject the drug slowly.

    To prevent and treat violations of capillary blood flow associated with traumatic, operating and burn shock intravenously drip 400-1000 ml per day (during 30-60 minutes).

    In surgical interventions on the heart and vessels injected intravenously intravenously with 10 ml / kg, 400 - 500 ml during the operation, and for 5-6 days after 10 ml / kg for administration.

    Children the total dose should not exceed 15 ml / kg / day.

    In cardiovascular operations children under the age of 2-3 years are administered 10 ml / kg once a day (for 60 minutes), up to 8 years - 7-10 ml / kg (1-2 times per day), up to 13 years - 5 -7 ml / kg (1-2 once a day), over 14 years - a dose for adults.

    For detoxification introduce 5-10 ml / kg for 60-90 minutes.

    Side effects:

    Allergic reactions: redness of the skin, rashes on the skin, nausea, fever, anaphylactic shock.

    Interaction:

    It is necessary to check beforehand for compatibility dextran with drugs that are scheduled for administration to the infusion solution.

    Form release / dosage:Solution for infusions, 10%.
    Packaging:

    In polymeric containers of 100, 200, 250, 400 and 500 ml or in packages for intravenous infusions of 250 and 500 ml.

    Each container or package for intravenous infusions is placed in a secondary package made of polyethylene or polypropylene films with instructions for use.

    Containers or bags for intravenous infusion in secondary bags are placed in boxes of corrugated cardboard.

    Storage conditions:

    Store in a dry place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Freezing during transportation is allowed.

    Shelf life:

    2 years.

    The drug should be used before the date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N002048 / 01
    Date of registration:15.12.2008
    The owner of the registration certificate:FIRM MEDPOLIMER, JSC FIRM MEDPOLIMER, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.01.2016
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