Intravenously sprayed, drip-drip and drip.
Dosage and rate of administration the drug should be selected individually in accordance with the indications and the patient's condition, the amount of blood pressure, heart rate, hematocrit.
Before applying the drug, a bioassay is performed and its result recorded in the medical history.
If possible, conduct intradermal for 24 hours before the infusion of the drug. To do this, from the container with dextran by puncturing the disposable system using a sterile syringe, take 0.2-0.3 ml of the drug that is administered intradermally at a dose of 0.05 ml to form a lemon crust on the inside of the forearm, shoulder or other area accessible to the visual evaluation of skin test. The doctor evaluates the reaction after 24 hours.The presence of redness (more than 1.5 mm in diameter) at the injection site, the formation of a papule or the appearance of symptoms of a general reaction in the form of nausea, dizziness, or other manifestations 10-15 min after injection indicates an increased sensitivity of the patient to the drug and its inability to use it patient. In the absence of any reactions, the patient is given the required amount of the preparation of the series that was used to conduct the intradermal test. It should be remembered that the skin test does not allow to reveal sensitization to dextran in 100% of patients. Therefore, in each case, the first 5-10 minutes of intravenous administration of the drug should be carefully monitored the patient.
In the case of emergency conditions, the bioassay is performed as follows: after a slow administration of the first 5 drops of the drug, the infusion is stopped for 3 minutes, then another 30 drops are added and the infusion is again stopped for 3 minutes. In the absence of a reaction, continue the administration of the drug.
1. When the capillary blood flow is disturbed (various forms of shock) are administered intravenously drip or drip-dropwise at a dose of 0.5 to 1.5 l until the hemodynamic parameters stabilize at the life-supporting level. If necessary, the amount of the drug can be increased to 2 liters.
Children with different forms of shock injected 5-10 ml / kg. If necessary, the dose may be increased to 15 ml / kg. It is not recommended to reduce the hematocrit value below 25%.
2. With cardiovascular and plastic operations injected intravenously drip: immediately before surgery - 10 ml / kg for 30-60 minutes for adults and children; during the operation - 500 ml for adults and 15 ml / kg for children; for 5-6 days after the operation - for 60 min 10 ml / kg once for adults and children over 14 years, 10 ml / kg once a day for children up to 2-3 years, 7-10 ml / kg 1-2 once a day for children under 8 years, for 5-7 ml / kg 1-2 times a day for children under 13 years.
3. In operations under conditions of artificial circulation the preparation is added to the blood of the patient at a rate of 10-20 ml / kg to fill the oxygenator pump. The concentration of dextran in the perfusion solution should not exceed 3%.
In the postoperative period, the doses of the drug are the same as for a violation of capillary blood flow.
4. With the aim of detoxification injected intravenously drip in a single dose of 500 to 1250 ml (children 5-10 ml / kg) for 60-90 minutes. If necessary, in the first day you can introduce another 500 ml of the drug (for children, the drug can be repeated in the same doses). In the following days, the drug is administered in a daily dose of 500 ml (children 5-10 ml / kg).