Intravenously sprayed, drip-drip and drip.
Dosage and rate of administration the drug should be selected individually in accordance with the indications and the patient's condition, the amount of blood pressure, heart rate, hematocrit.
Immediately before the application of dextran, with the exception of urgent conditions, a skin test is performed.
Intradermal test is carried out 24 hours before the infusion of the drug. For this purpose, 0.05 ml of the preparation is injected intradermally with the formation of lemon crust on the inside of the forearm, shoulder or other area accessible for visual evaluation of the skin test. The doctor evaluates the reaction after 24 hours.
Presence of redness on the injection site, formation of a papule or the appearance of symptoms of a general reaction in the form of nausea, dizziness, or other manifestations 10-15 minutes after the injection, indicates an increased sensitivity of the patient to the drug and the impossibility of using the drug in this patient. In the absence of any reactions, the patient is given the required amount of the preparation of the series that was used to conduct the intradermal test. The results of the sample are recorded in the medical history.
It should be remembered that the skin test does not allow to reveal sensitization to dextran in 100% of patients. Therefore, in the first 5-10 minutes as the intravenous drug is administered in each case, it is necessary to closely monitor the patient's condition.In the case of emergency conditions, when applying the drug, it is necessary to conduct a bioassay: after a slow introduction of the first 5 drops of the drug, stopping for 3 minutes. then add another 30 drops and again stop the infusion for 3 minutes. In the absence of a reaction, continue the injection. The results of the bioassay must be recorded in the medical history.
When there is a violation of capillary blood flow (various forms of shock) injected intravenously drip or drip-drop, at a dose of 0.5 to 1.5 liters, until the hemodynamic parameters stabilize at the life-supporting level. If necessary, the amount of the drug can be increased to 2 liters.
Children with various forms of shock are administered at the rate of 5-10 ml / kg, the dose can be increased if necessary to a maximum of 15 ml / kg. It is not recommended to reduce the hematocrit value below 25%.
With cardiovascular and plastic operations injected intravenously drastically, immediately before surgery, for 30-60 minutes adults and children at a dose of 10 ml / kg, during surgery, adults - 500 ml, children - 15 ml / kg.
After operation the drug is administered intravenously drip (within 60 minutes) for 5-6 days at the rate of:
adults - 10 ml / kg once,
children up to 2-3 years - 10 ml / kg 1 time per day,
children under 8 years - 7-10 ml / kg 1-2 times a day,
children under 13 years - 5-7 ml / kg 1-2 times a day,
for children older than 14 years - the doses are the same as for adults.
In operations with artificial circulation the drug is added to the blood at the rate of 10-20 ml / kg of the patient's body weight to fill the oxygenator pump, the concentration of dextran in the perfusion solution should not exceed 3%. In the postoperative period, the doses of the drug are the same as for a violation of capillary blood flow.
With the aim of detoxification injected intravenously drip in a single dose of 500 to 1250 ml (in children 5-10 ml / kg) for 60-90 minutes. If necessary, you can introduce another 500 ml of the drug in the first day (in children the administration of the drug in the first day can be repeated in the same doses). In the following days, the drug is administered drip, adults - in a daily dose of 500 ml, children - at a rate of 5-10 ml / kg