In the treatment of Rifampicin-Ferein®, gastrointestinal function disorders (decreased appetite, nausea, vomiting, diarrhea) are possible. These phenomena usually pass independently in 2-3 days without drug withdrawal. Rifampicin-Ferein® can have a hepatotoxic effect (an increase in the content of transaminases and bilirubin in the serum, jaundice). For the timely detection and prevention of hepatotoxic action, treatment with Rifampicin-Ferein® should be started after a study of liver function (determination of bilirubin and aminotransferase levels in the blood, timol assay), and in the process of treatment, to conduct it monthly. In patients who have had past hepatitis or who suffer from cirrhosis of the liver, these studies should be conducted every 2 weeks. Moderate dysfunctions of the liver usually have a transient nature and can disappear without drug discontinuation in the appointment of allochol, methionine, pyridoxine, vitamin B12.With increasing phenomena of liver function abnormalities, the use of Rifampicin-Ferein® should be discontinued.
In the treatment of Rifampicin-Ferein®, the development of leukopenia and thrombocytopenia is possible. allergic reactions. The latter manifest themselves as skin rashes, eosinophilia, rarely - bronchospasm and Quincke's edema. When intermittent treatment, irregular administration of the drug, or with the resumption of treatment with Rifampicin-Ferein® after a break, severe allergic reactions may occur in the form of influenza-like fever, acute renal-hepatic insufficiency or thrombopenic purpura. These complications are sometimes preceded by signs of drug sensitization (temperature rise after taking the drug, increasing eosinophilia, bronchospasm, and positive tests by Shelley, Ouenier, etc.). To prevent these phenomena, the drug should be administered in small doses (0.15 g per day). In cases when signs of sensitization to Rifampicin-Ferein® were noted at the previous stage of treatment, it is used under the control of temperature measurement after taking the drug (within 3 hours in the first 2-3 days).With good tolerability, the dose of antibiotic can be increased to the usual therapeutic dose.
When allergic reactions occur, Rifampicin-Ferein® is canceled and desensitizing therapy is administered (antihistamines, calcium preparations, corticosteroid hormones, etc.). In cases of severe allergic reactions, it is necessary to administer parenterally large doses of corticosteroid hormones, antihistamines, intravenous haemodes, isotonic sodium chloride solution, diuretics, etc.
In patients using the drug, urine, tear fluid, sputum becomes orange-red.
With the rapid intravenous administration of Rifampicin-Ferein® in patients, it is possible to lower blood pressure, as a result of which intravenous infusion of the drug should be carried out under the control of blood pressure during the administration of the drug. With prolonged intravenous administration, phlebitis may develop.