Parenterally, intravenously (IV), drip. In / in - with acute and progressive forms of destructive pulmonary tuberculosis,severe purulent-septic processes, when it is necessary to quickly create high concentrations of the drug in the blood and in the focus of the infection, in cases when taking the drug inside is difficult or badly tolerated by patients.
Preparation of solution for IV infusion: dilute lyophilizate, adding 10 ml of water for injection into the vial with the drug. Shake the vial to ensure complete dissolution of the contents of the vial. Then mix the resulting solution with 500 ml of 5% dextrose solution, 5% fructose solution or 0.9% sodium chloride solution. If a smaller dose of rifampicin is needed, the required amount of ml from the vial with the dissolved drug (10 ml = 600 mg of rifampicin, 5 ml, = 300 mg of rifampicin, etc.) is taken and mixed with a 5% solution of dextrose, 5% solution of fructose or 0.9% solution of sodium chloride. The rate of administration is 60 - 80 cap / min. Dosage regimen is set by the doctor individually depending on the severity of the disease and the patient's response to treatment.
If the doctor is not assigned otherwise, the following dosing regimens are recommended:
Adults: 10 mg / kg body weight, the maximum daily dose - 600 mg.
Children under 6 years and infants older than 2 months: 15 mg / kg of body weight per day.
Children from 6 to 12 years: 10-20 mg / kg per day, with long-term therapy should exceed 450 mg daily.
Children over 12 years of age: in the same doses as for adults.
For the treatment of tuberculosis
With IV administration, the daily dose for adults is 0.45 g, in severe fast-progressing forms - 0.6 g, is given in 1 dose. The duration of IV administration depends on the tolerability and is 1 month or more (with the subsequent transition to oral administration). The total duration of use for tuberculosis is determined by the effectiveness of treatment and can be achieved 1d.
For the treatment of tuberculosis, at least one antituberculous agent is combined (isoniazid, pyrazinamide, ethambutol, streptomycin). Adults with a body weight of less than 50 kg - 450 mg / day; 50 kg and more - 600 mg / day. Children and newborns - 10 -20 mg / kg per day; the maximum daily dose is 600 mg.
In case of tuberculous meningitis, disseminated tuberculosis, spinal cord injury with neurological manifestations, when tuberculosis is combined with HIV the total duration of treatment is 9 months, the drug is used daily, the first 2 months in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin), 7 months - in combination with isoniazid.
In the case of pulmonary tuberculosis and detection of mycobacteria in sputum, the following 3 regimens are used (all with a duration of 6 months):
1 The first 2 months - as indicated above; 4 months - daily, in combination with isoniazid.
2 The first 2 months - as indicated above; 4 months - in combination with isoniazid, 2-3 times during, every week.
3 Throughout the course - the reception in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin) 3 times during each week. In cases where antituberculous drugs are used 2-3 times "per week (as well as in case of exacerbations of the disease or inefficiency of therapy), their reception should be carried out under the supervision of medical personnel.
With infections of non-tuberculous etiology
The daily dose for adults is 0,3 - 0,9 g (maximum - 1,2 g), for children over 2 months - 10-20 mg / kg. The daily dose is divided into 2 - 3 injections. Duration of treatment
is set individually, depending on the effectiveness and can be 7 -
10 days. I / O administration should be discontinued as soon as possible for admission
inside.
For the treatment of leprosy:
For the treatment of multibacillary types of leprosy (lepromatous, borderline,lepromatous and borderline) adults - 600 mg once a month in combination with dapsone (100 mg once a day) and clofazimine (50 mg once a day + 300 mg once a month); Children 10 mg / kg once a month in combination with dapsone (1-2 mg / kg / day) and clofazimine (50 mg every other day + 200 mg once a month). The minimum duration of treatment is 2 years.
For treatment of multibacillary types of leprosy (tuberculoid and border tuberculoid) adults - 600 mg once a month, in combination with dapsone - 100 mg (1-2 mg / kg) once a day; Children - 10 mg / kg once a month. Duration of treatment - 6 months.
For treatment of brucellosis - 900 mg / day once in combination with doxycycline; the average duration of treatment is 45 days.
For the prevention of meningococcal meningitis - 2 times a day every 12 mg for 2 days. Single doses for adults - 600 mg; for children - 10 mg / kg; for newborns -
5 mg / kg.
Patients with impaired hepatic and / or renal function:
Patients with impaired renal excretory function and preserved liver function dose adjustment is required only when it exceeds 600 mg / day. Features of application after interruption of therapy
After interruption of therapy rifampicin is prescribed with a gradual increase in the dose.It is necessary to monitor the function of the kidneys, if necessary, the appointment of glucocorticosteroids is recommended.