Inside, on an empty stomach, 30 minutes before meals. For the treatment of tuberculosis, at least one antituberculous agent is combined (isoniazid, pyrazinamide, ethambutol, streptomycin and etc).
Adults with a body weight of less than 50 kg - 450 mg/cyi; 50 kg and more - 600 mg/cyt. Children ctarch 3-х years- 10 mg / kg per day; the maximum daily dose is 450 mg.
In case of tuberculous meningitis, disseminated tuberculosis, spinal cord injury with neurological manifestations, when tuberculosis is combined with HIV infection, the total duration of treatment is 9 months, the drug is used daily, the first 2 months in combination with isoniazid, pyrazinamide and ethambutol (or streptomycin), 7 months - in combination with isoniazid.
In the case of pulmonary tuberculosis and detection of mycobacteria in sputum, the following 3 regimens are used (all with a duration of 6 months):
1. The first 2 months - as indicated above; 4 months - daily, in combination with isoniazid.
2 .. The first 2 months - as indicated above; 4 months - in combination with isoniazid, 2-3 times during
every week.
3. Throughout the course of the course - taking in combination with isoniazid, pyrazinamide and Etambutol (or streptomycin) 3 times during each week. In cases where anti-TB drugs are used 2-3 times a week (as well as in case of exacerbation of the disease or inefficiency of therapy), they should be taken under the supervision of medical personnel.
For the treatment of multibacillary types of leprosy (lepromatous, borderline,lepromatous and borderline) adults - 600 mg once a month in combination with dapsone (100 mg once a day) and clofazimine (50 mg once a day + 300 mg once a month); children ctarch 3 years - 10 mg / kg once a month in combination with dapsone (1-2 mg / kg/cyt) and clofazimine (50 mg every other day + 200 mg once a month). The minimum duration of treatment is 2 years.
For treatment of multibacillary types of leprosy (tuberculoid and border tuberculoid) adults - 600 mg once a month, in combination with dapsone -100 mg (1-2 mg / kg) once a day; children ciapme 3 lei - 10 mg / kg once a month, in combination with dapsone -1-2 mg / kg / day. Duration of treatment - 6 months.
For the treatment of infectious diseases caused by sensitive microorganisms, it is prescribed in combination with other antimicrobial agents. The daily intake for adults is 0.6-1.2 g; for children ctarch 3 lenth - 10-20 mg / kg .. Multiplicity of admission - 2 times a day.
For the treatment of brucellosis - 900 mg/cyt once, in the morning on an empty stomach, in combination with doxycycline; the average duration of treatment is 45 days.
For the prevention of meningococcal meningitis - 2 times a day and every 12 hours for 2 days. Single doses for adults - 600 mg; for children ctarch 3 lenth of the bed -10 mg / kg. Patients with impaired renal excretory function and preserved liver function are only required to correct the dosem when it exceeds 600 mg/cyt.